{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T17:14:30Z","timestamp":1788196470531,"version":"build-2803163510"},"reference-count":102,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    Candidozyma auris (formerly Candida auris) has emerged as a formidable global health threat, characterized by its multidrug resistance (MDR), high transmissibility in healthcare settings, and significant mortality. The World Health Organization classifies it as a \u2018critical priority\u2019 fungal pathogen. Conventional infection control paradigms, often applying a \u2018one-size-fits-all\u2019 approach, have struggled to contain\n                    <jats:italic>C. auris<\/jats:italic>\n                    due to its unique environmental resilience and transmission dynamics. This review departs from traditional linear analyses and proposes a novel, scenario-based framework to deconstruct the complex challenges of\n                    <jats:italic>C. auris<\/jats:italic>\n                    management. We dissect the distinct transmission dynamics and control vulnerabilities across four high-risk clinical scenarios: the intensive care unit (ICU), long-term care facility (LTCF), high-risk surgical ward, and outpatient settings. Building on this analysis, we introduce the \u2018\n                    <jats:italic>C. auris<\/jats:italic>\n                    Integrated Control Bundle,\u2019 a multi-layered, adaptable toolkit combining patient-level, facility-level, and system-level interventions. This framework provides clinicians and infection preventionists with a practical, evidence-based paradigm to design and implement setting-specific, resource-optimized strategies against this resilient pathogen. We also review current diagnostic and therapeutic challenges, emphasizing the urgent need for rapid diagnostics and novel treatment options. By addressing key unanswered questions, this review aims to guide future research and strengthen the global response to\n                    <jats:italic>C. auris<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2026.1796121","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T06:43:03Z","timestamp":1773124983000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Tackling a global threat: a clinical scenario-based framework for preventing and managing Candidozyma auris infections"],"prefix":"10.3389","volume":"16","author":[{"given":"Jinghua","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Infection Control, Zhangjiagang Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine","place":["Zhangjiagang, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Reproduction, Zhangjiagang Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine","place":["Zhangjiagang, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Kunshan Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine","place":["Kunshan, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"807","DOI":"10.3390\/microorganisms9040807","article-title":"Candida auris: epidemiology, diagnosis, pathogenesis, antifungal susceptibility, and infection control measures to combat the spread of infections in healthcare facilities","volume":"9","author":"Ahmad","year":"2021","journal-title":"Microorganisms"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.3390\/antibiotics14121206","article-title":"Risk factors and outcomes for invasive infection among patients colonized with candidozyma auris: A case-control study","volume":"14","author":"Alowais","year":"2025","journal-title":"Antibiotics (Basel Switzerland)"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e1012699","DOI":"10.1371\/journal.ppat.1012699","article-title":"Single-cell transcriptomics unveils skin cell specific antifungal immune responses and IL-1Ra- IL-1R immune evasion strategies of emerging fungal pathogen Candida auris","volume":"20","author":"Balakumar","year":"2024","journal-title":"PloS Pathog."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e0052524","DOI":"10.1128\/jcm.00525-24","article-title":"A simple and sensitive test for Candida auris colonization, surveillance, and infection control suitable for near patient use","volume":"62","author":"Banik","year":"2024","journal-title":"J. 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