{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:12:40Z","timestamp":1788415960825,"version":"build-2803163510"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To explore the epidemiological characteristics of EnE and the molecular traits of the\n                      <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                      (KP).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We revived 40 strains of the KP, utilized whole-genome sequencing technology to understand their molecular epidemiological characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 103 EnE patients (69.90% male, 56.31% left eye), vision loss was the chief complaint (96.12%). Extraocular infections were present in 63.11% of patients, most commonly liver abscess (45.00%). KP comprised 81.82% of culture-positive cases. Among 40 KP strains analyzed, 82.5% were hypervirulent KP (hvKP). Phylogenetic analysis revealed the dominance of ST23-K1 lineages. Intravitreal injection was associated with a significantly reduced risk of poor visual prognosis (RR\u00a0=\u00a00.061, 95%CI: 0.005\u20130.442) and emerged as an independent protective factor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The incidence of EnE showed an increasing trend, primarily driven by hvKP ST23-K1. A comprehensive search for systemic infection foci, particularly liver abscesses, is essential. A negative string test result does not exclude hvKP. Timely intravitreal antimicrobial injection is a critical modifiable factor for improving visual prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1805346","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:15:14Z","timestamp":1788412514000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Retrospective single-center study of endogenous endophthalmitis, Northeastern China, 2010-2023"],"prefix":"10.3389","volume":"16","author":[{"given":"Deng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Infectious Disease, Xiamen Xinglin Hospital","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology,The First Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"General Intensive Care Unit, Zhaoqing Hospital, The Third Affiliated Hospital of Sun Yat-sen University","place":["Zhaoqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xifan","family":"Zhang","sequence":"additional","affiliation":[{"name":"First Department of Infectious Disease, The First Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sufei","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baiyi","family":"Chen","sequence":"additional","affiliation":[{"name":"First Department of Infectious Disease, The First Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzhuo","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingping","family":"Zhang","sequence":"additional","affiliation":[{"name":"First Department of Infectious Disease, The First Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"First Department of Infectious Disease, The First Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1097\/ICU.0000000000001152","article-title":"Management of endophthalmitis: to culture or not to culture","volume":"36","author":"Ag","year":"2025","journal-title":"Curr. 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