{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T05:48:06Z","timestamp":1782712086321,"version":"3.54.5"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Antibacterial modification of dental adhesives has emerged as a viable strategy for caries prevention. In this study, a newly identified dual-target antimicrobial, SCH-79797, known for its strong antibiofilm activity, was incorporated into a dental adhesive. Its antibiofilm performance was subsequently evaluated using a\n                      <jats:italic>Streptococcus mutans<\/jats:italic>\n                      (\n                      <jats:italic>S. mutans<\/jats:italic>\n                      ) biofilm model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The bonding performance, polymerization behavior and surface wettability of the SCH-79797\u2013modified adhesive were evaluated by shear bond strength testing, degree of conversion, and water contact angle measurements, respectively. Biocompatibility was examined in L929 fibroblasts using CCK-8 assays and live\/dead cell staining. Antibacterial activity against biofilms was evaluated through CFU counting, MTT assays, SEM observation, and live\/dead bacterial staining. In addition, biofilm virulence was evaluated by analyzing water-insoluble polysaccharide and extracellular polysaccharide (EPS) production, as well as changes in pH and lactic acid production.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Incorporating SCH-79797 at concentrations up to 0.5% did not adversely affect the adhesive properties and resulted in minimal cytotoxicity. Compared with the control, the SCH-79797-modified adhesive reduced bacterial viability by approximately 6 log CFU, and significantly decreased lactate production and EPS synthesis by approximately 90% and 90%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These findings indicate that SCH-79797-modified dental adhesives possess promising\n                      <jats:italic>in vitro<\/jats:italic>\n                      anticaries activity against cariogenic bacteria.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1808368","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T05:40:43Z","timestamp":1782711643000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Antibacterial effect of a dental adhesive containing SCH-79797 on Streptococcus mutans biofilms"],"prefix":"10.3389","volume":"16","author":[{"given":"Gaozhe","family":"Zheng","sequence":"first","affiliation":[{"name":"School and Hospital of Stomatology, Wenzhou Medical University","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology, Wenzhou Medical University","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyun","family":"Dong","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology, Wenzhou Medical University","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhe","family":"Shao","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology, Wenzhou Medical University","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuli","family":"Deng","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology, Wenzhou Medical University","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihuai","family":"Pan","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology, Wenzhou Medical University","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology, Wenzhou Medical University","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.1016\/s0960-894x(99)00339-x","article-title":"Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists","volume":"9","author":"Ahn","year":"1999","journal-title":"Bioorg. 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