{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T19:30:33Z","timestamp":1785007833452,"version":"3.55.0"},"reference-count":140,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    Chronic inflammatory diseases, closely linked to gut microbiota dysbiosis, pose a major global health burden.\n                    <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                    (\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    ), a key gut commensal, sustains immune homeostasis and metabolic balance, emerging as a promising next-generation probiotic. This review synthesizes current evidence on the mechanisms such as regulating the intestinal barrier, immunomodulation, mediating anti-inflammatory metabolites and regulating microbiota and therapeutic potential of\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    in inflammation-related diseases. Integrating these with experimental\/clinical data across inflammation-related disorders establishes a coherent framework. Beyond live bacteria, advances in pasteurized formulations and bioactive derivatives highlight complementary advantages.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2026.1819005","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T06:11:59Z","timestamp":1779430319000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Mechanism and application of Akkermansia muciniphila in inflammatory diseases"],"prefix":"10.3389","volume":"16","author":[{"given":"Luyu","family":"Xie","sequence":"first","affiliation":[{"name":"School of Synthetic Biology and Biomanufacturing, Tianjin University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juane","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Synthetic Biology and Biomanufacturing, Tianjin University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Han","sequence":"additional","affiliation":[{"name":"Zhe Jiang Institute of Tianjin University","place":["Shaoxing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengli","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhe Jiang Institute of Tianjin University","place":["Shaoxing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Synthetic Biology and Biomanufacturing, Tianjin University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[{"name":"Zhe Jiang Institute of Tianjin University","place":["Shaoxing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Qiao","sequence":"additional","affiliation":[{"name":"School of Synthetic Biology and Biomanufacturing, Tianjin University","place":["Tianjin, China"]},{"name":"Zhe Jiang Institute of Tianjin University","place":["Shaoxing, China"]},{"name":"State Key Laboratory of Synthetic Biology, Tianjin University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/nu18050777","article-title":"Intermittent fasting and Akkermansia muciniphila exert independent and combined benefits on behavioral and neurobiological deficits in a VPA-induced autism rat model","volume":"18","author":"Ad\u0131g\u00fczel","year":"2026","journal-title":"Nutrients"},{"key":"B2","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s13099-025-00728-x","article-title":"Comparative study of liver injury protection by Akkermansia muciniphila and Faecalibacterium prausnitzii interventions in live and cell-free supernatant forms via targeting the hepcidin \u2013 ferroportin axis in mice with CCl4-induced liver fibrosis","volume":"17","author":"Ahmadi Badi","year":"2025","journal-title":"Gut. 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