{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:01:01Z","timestamp":1790226061539,"version":"4.1.0"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Vaginal candidiasis (VC), mainly triggered by\n                      <jats:italic>Candida<\/jats:italic>\n                      species, ranks among the most\u2011common reproductive\u2011tract infections worldwide. Over\u2011utilization of antibiotics and antifungal medicines aggravates fungal drug\u2011resistance, which makes it imperative to explore novel alternative therapies. This work intended to investigate the anti\u2011\n                      <jats:italic>Candida\u2011albicans<\/jats:italic>\n                      activity of\n                      <jats:italic>Lacticaseibacillus paracasei<\/jats:italic>\n                      VCare\u2011360.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The in\u2011vitro capacities of the strain to produce hydrogen peroxide and lactic acid and its antifungal activity were tested. A vaginal\u2011epithelial\u2011cell model was adopted to evaluate bacterial competitive adhesion and the regulation of pro\u2011inflammatory cytokine secretion. A mouse VC animal\u2011model was constructed to assess vaginal mucosal repair, inflammatory\u2011factor levels, myeloperoxidase activity, as well as vaginal and faecal microbiota composition after probiotic intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>L. paracasei<\/jats:italic>\n                      VCare\u2011360 competed against\n                      <jats:italic>C. albicans<\/jats:italic>\n                      for vaginal\u2011epithelial\u2011cell adhesion and suppressed fungal colonization. It lowered the release of pro\u2011inflammatory cytokines\n                      <jats:italic>in-vitro<\/jats:italic>\n                      . In mice, this probiotic alleviated vaginal epithelial exfoliation, repaired damaged vaginal mucosa and relieved local inflammation (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.05). It also decreased pro\u2011inflammatory cytokine concentrations and myeloperoxidase activity in blood and vaginal tissue. Sequencing results demonstrated that VCare\u2011360 enriched the relative abundance of\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      and cut down vaginal\n                      <jats:italic>Escherichia-Shigella<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Lacticaseibacillus paracasei<\/jats:italic>\n                      VCare\u2011360 can inhibit\n                      <jats:italic>C. albicans<\/jats:italic>\n                      infection, modulate vaginal flora and restore the vaginal mucosal barrier, and serves as a promising probiotic candidate for the treatment of\n                      <jats:italic>Candida<\/jats:italic>\n                      \u2011induced vaginal candidiasis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1829740","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:32:33Z","timestamp":1790224353000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Inhibitory effect of Lacticaseibacillus paracasei VCare-360 on Candida albicans in mice with vaginal candidiasis"],"prefix":"10.3389","volume":"16","author":[{"given":"Duo","family":"Han","sequence":"first","affiliation":[{"name":"Global R&D Innovation Center, Inner Mongolia Mengniu Dairy (Group) Co.Ltd.","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yang","sequence":"additional","affiliation":[{"name":"Microbial Innovation and Research Center, Nutrition & Health Research Institute, COFCO Corporation","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Hui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Global R&D Innovation Center, Inner Mongolia Mengniu Dairy (Group) Co.Ltd.","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Xing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Global R&D Innovation Center, Inner Mongolia Mengniu Dairy (Group) Co.Ltd.","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue Jian","family":"Mao","sequence":"additional","affiliation":[{"name":"Global R&D Innovation Center, Inner Mongolia Mengniu Dairy (Group) Co.Ltd.","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Wei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Microbial Innovation and Research Center, Nutrition & Health Research Institute, COFCO Corporation","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Yang","sequence":"additional","affiliation":[{"name":"Microbial Innovation and Research Center, Nutrition & Health Research Institute, COFCO Corporation","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia Lun","family":"Chen","sequence":"additional","affiliation":[{"name":"Global R&D Innovation Center, Inner Mongolia Mengniu Dairy (Group) Co.Ltd.","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02184","article-title":"Female gut and genital tract microbiota-induced crosstalk and differential effects of short-chain fatty acids on immune sequelae","volume":"11","author":"Amabebe","year":"2020","journal-title":"Front. 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