{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T05:49:26Z","timestamp":1782107366471,"version":"3.54.5"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Osteoarthritis (OA) is a globally prevalent degenerative joint disorder that imposes significant socioeconomic burdens. While traditionally viewed as a localized \u201cwear-and-tear\u201d disease, emerging evidence supports a systemic pathogenesis involving the gut-joint axis. The oral-gut-joint pathway remains underexplored in OA pathophysiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to characterize oral and gut microbiota signatures in OA patients and elucidate their functional connections to cartilage degeneration through multiomics integration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross-sectional observational study involving 25 OA patients and 20 healthy controls. 16S rDNA gene amplicon sequencing was performed on fecal and oropharyngeal swab samples. Cartilage tissues were subjected to transcriptomic and proteomic analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified distinct dysbiosis patterns in both the gut and oral microbiomes of OA patients. The \u03b1-diversity of the gut microbiota significantly increased (P&amp;lt;0.05) with enrichment of\n                      <jats:italic>Ruminococcaceae<\/jats:italic>\n                      and\n                      <jats:italic>Subdoligranulum<\/jats:italic>\n                      . Concurrently, the oral microbiota showed increased \u03b1-diversity and activation of the lipopolysaccharide biosynthesis pathway. We constructed two significant cross-omics correlation modules: one linking gut microbes (\n                      <jats:italic>Lachnospiraceae<\/jats:italic>\n                      and\n                      <jats:italic>Muribaculaceae<\/jats:italic>\n                      ) to cartilage inflammatory genes (\n                      <jats:italic>MAPK11<\/jats:italic>\n                      ,\n                      <jats:italic>ITGB3<\/jats:italic>\n                      ,\n                      <jats:italic>CD55<\/jats:italic>\n                      and\n                      <jats:italic>ANGPT2<\/jats:italic>\n                      ) and extracellular matrix remodelling proteins and another connecting gut microbes (\n                      <jats:italic>Helicobacter<\/jats:italic>\n                      ,\n                      <jats:italic>Pseudomonas<\/jats:italic>\n                      , and\n                      <jats:italic>Phocea<\/jats:italic>\n                      ) with\n                      <jats:italic>CXCL14<\/jats:italic>\n                      and\n                      <jats:italic>GNGT2<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study revealed the dysbiotic characteristics of the oral-gut microbiome and its complex associations with pathological changes in cartilage. These findings offer novel mechanistic insights and potential therapeutic targets for microbiota-based precision interventions in OA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1833218","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T05:39:47Z","timestamp":1782106787000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The oral-gut-joint axis in osteoarthritis: a multiomics case-control study"],"prefix":"10.3389","volume":"16","author":[{"given":"Yuchi","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University","place":["Jinan, China"]},{"name":"Qingdao University, Qingdao Medical College","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"Gong","sequence":"additional","affiliation":[{"name":"Qingdao University, Qingdao Medical College","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Weifang People\u2019s Hospital, Shandong Second Medical University","place":["Weifang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Joint Surgery, Weifang People\u2019s Hospital, Shandong Second Medical University","place":["Weifang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/s41584-024-01143-3","article-title":"The role of obesity and adipose tissue dysfunction in osteoarthritis pain","volume":"20","author":"Binvignat","year":"2024","journal-title":"Nat. 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