{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:10:46Z","timestamp":1779343846958,"version":"3.51.4"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To analyze the clinical characteristics of hospitalized children with respiratory syncytial virus (RSV) infection and identify independent risk factors for intensive care unit (ICU) admission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included hospitalized children with polymerase chain reaction (PCR)-confirmed RSV infection between July 2022 and April 2025. Epidemiological, clinical, laboratory, and imaging data were collected. Multivariable logistic regression analysis was employed to determine independent predictors of ICU admission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 95,311 children tested for acute respiratory infections, 14,583 (15.3%) were RSV-positive, of whom 5,814 (39.9%) were hospitalized. The hospitalized cohort was predominantly infants under one year of age (47.2%). The most common manifestations were cough (91.6%), sputum production (69.3%), and fever (55.8%). Laboratory findings revealed elevated median serum levels of procalcitonin, creatine kinase-MB, and lactate dehydrogenase. Chest computed tomography primarily revealed increased bronchial wall thickening (87.3%) and patchy shadows (67.2%). Complications were frequent, affecting the respiratory system in 53.4% of cases and other systems in 33.5%. A total of 710 children (12.2%) required ICU admission. To identify early warning predictors, a multivariable logistic regression model excluding acute clinical presentations (shortness of breath and dyspnea) identified respiratory complications (OR\u00a0=\u00a05.20, 95% CI: 3.82\u20137.07,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.001), bilateral consolidation on chest imaging (OR\u00a0=\u00a02.08, 95% CI: 1.52\u20132.85,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.001), and prolonged fever duration (OR\u00a0=\u00a01.19 per day, 95% CI: 1.14\u20131.23,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.001) as the strongest independent risk factors for ICU admission.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hospitalized children with RSV infection are predominantly young infants and are prone to complex manifestations and multi-system complications. Respiratory complications, bilateral consolidation, and prolonged fever duration are key predictors of ICU admission. This study provides important evidence for the early identification of high-risk children and the optimization of critical care resource allocation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1834056","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:43:07Z","timestamp":1779342187000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk factors for ICU admission in hospitalized children with respiratory syncytial virus infection"],"prefix":"10.3389","volume":"16","author":[{"given":"Chunyun","family":"Fu","sequence":"first","affiliation":[{"name":"Medical Science Laboratory, Children\u2019s Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region","place":["Nanning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengkui","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of 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