{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T05:01:07Z","timestamp":1780290067957,"version":"3.54.0"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    Goatpox virus (GTPV) is an important capripoxvirus that causes severe disease in goats, yet the functions of many GTPV-encoded proteins remain unclear. In this study, eukaryotic translation initiation factor 4A1 (eIF4A1) was identified as a host protein interacting with GTPV Hrf-063 by GST pull-down combined with LC-MS\/MS analysis. This interaction was further confirmed by reciprocal pull-down assays and co-immunoprecipitation in mammalian cells. Domain-mapping analysis showed that the N-terminal region of Hrf-063 and amino acids 211\u2013330 of eIF4A1 were critical for their interaction, and confocal microscopy demonstrated that both proteins predominantly co-localized in the cytoplasm. Functional analyses showed that Hrf-063 was negatively associated with eIF4A1 expression during GTPV infection, while eIF4A1 modulation affected the expression of the GTPV virulence-associated protein Klp2. In addition, perturbation of Hrf-063 or eIF4A1 altered the expression of STAT1 and CAV1, and Hrf-063 regulated ISG15 and STING1 transcription in a time- and infection-dependent manner. TCID\n                    <jats:sub>50<\/jats:sub>\n                    assays further showed that altered Hrf-063 or eIF4A1 expression affected infectious GTPV production. Collectively, these findings identify eIF4A1 as a host interaction partner of GTPV Hrf-063 and suggest that the Hrf-063\u2013eIF4A1 axis is involved in viral protein expression, innate immune regulation, and infectious virus production.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2026.1840976","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T04:18:22Z","timestamp":1780287502000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Goatpox virus Hrf-063 interacts with host eIF4A1 and is associated with altered expression of antiviral signaling-related factors"],"prefix":"10.3389","volume":"16","author":[{"given":"Baoqin","family":"Long","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Tarim University, Tarim Animal Disease Diagnosis and Prevention Engineering Laboratory, Xinjiang Production and Construction Corps","place":["Alaer, Xinjiang, 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