{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:08:11Z","timestamp":1784092091084,"version":"3.55.0"},"reference-count":135,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Herpes Zoster Neuralgia (HZN) is a condition caused by the varicella-zoster virus, characterized primarily by pain. The Transient Receptor Potential Vanilloid 1 (TRPV1), which acts as a pain mediator, plays a significant role in pain signaling and the regulation of neuroinflammation. In this context, this paper summarizes the biological characteristics of TRPV1, its dynamic expression in HZN, and its mechanisms for mediating neuroinflammatory processes and pain signal conduction. It posits that the inhibition of TRPV1 may alleviate HZN. Furthermore, the paper discusses the research and development progress, as well as the challenges associated with TRPV1 antagonists as a new class of analgesics, thereby providing new insights for the treatment of HZN.<\/jats:p>","DOI":"10.3389\/fcimb.2026.1841790","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T04:46:46Z","timestamp":1784090806000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting TRPV1 channels: new perspectives on the mechanisms of analgesia for herpes zoster neuralgia and advances in therapeutic research"],"prefix":"10.3389","volume":"16","author":[{"given":"Ying","family":"Zhang","sequence":"first","affiliation":[{"name":"The Fourth Affiliated Hospital of Yunnan University of Chinese Medicine","place":["Yuxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[{"name":"The Fourth Affiliated Hospital of Yunnan University of Chinese Medicine","place":["Yuxi, China"]},{"name":"Yunnan University of Chinese Medicine","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niqin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Yunnan University of Chinese Medicine","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wu","sequence":"additional","affiliation":[{"name":"The Fourth Affiliated Hospital of Yunnan University of Chinese Medicine","place":["Yuxi, China"]},{"name":"Yunnan University of Chinese Medicine","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2020.109178","article-title":"Modulation of TRPV1 channel function by natural products in the treatment of pain","volume":"330","author":"Abbas","year":"2020","journal-title":"Chem. Biol. Interact."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202101717","article-title":"Rational design of a modality-specific inhibitor of TRPM8 channel against oxaliplatin-induced cold allodynia","volume":"8","author":"Aierken","year":"2021","journal-title":"Adv. Sci. (Weinh)"},{"key":"B3","doi-asserted-by":"publisher","first-page":"10581","DOI":"10.1038\/s41598-020-67396-6","article-title":"Extracellular glucose is crucially involved in the fate decision of LPS-stimulated RAW264.7 murine macrophage cells","volume":"10","author":"Aki","year":"2020","journal-title":"Sci. Rep."},{"key":"B4","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.neuroscience.2013.07.035","article-title":"Neural processing of itch","volume":"250","author":"Akiyama","year":"2013","journal-title":"Neuroscience"},{"key":"B5","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s12931-019-1060-8","article-title":"Bradykinin sensitizes the cough reflex via a B(2) receptor dependent activation of TRPV1 and TRPA1 channels through metabolites of cyclooxygenase and 12-lipoxygenase","volume":"20","author":"Al-Shamlan","year":"2019","journal-title":"Respir. Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1093\/brain\/awaf044","article-title":"Novel insight into TRPV1-induced mitochondrial dysfunction in neuropathic pain","volume":"148","author":"Awad-Igbaria","year":"2025","journal-title":"Brain"},{"key":"B7","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1111\/j.1526-4637.2009.00793.x","article-title":"NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomized, double-blind, controlled study with an open-label extension","volume":"11","author":"Backonja","year":"2010","journal-title":"Pain Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"13513","DOI":"10.1007\/s12035-025-05136-5","article-title":"The antinociceptive effect of nicorandil in neuropathic and nociceptive pain is partially mediated via TRPV1\/opioidergic signaling","volume":"62","author":"Badr","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"6135","DOI":"10.3390\/ijms22116135","article-title":"TRPV1: Role in skin and skin diseases and potential target for improving wound healing","volume":"22","author":"Bagood","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3390\/v11020103","article-title":"Current in vitro models to study varicella zoster virus latency and reactivation","volume":"11","author":"Baird","year":"2019","journal-title":"Viruses"},{"key":"B11","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1097\/j.pain.0000000000002688","article-title":"Combination pharmacotherapy for the treatment of neuropathic pain in adults: systematic review and meta-analysis","volume":"164","author":"Balanaser","year":"2023","journal-title":"Pain"},{"key":"B12","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","article-title":"Cellular and molecular mechanisms of pain","volume":"139","author":"Basbaum","year":"2009","journal-title":"Cell"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.09674","article-title":"Keratinocytes can modulate and directly initiate nociceptive responses","volume":"4","author":"Baumbauer","year":"2015","journal-title":"Elife"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1080\/19336950.2026.2616902","article-title":"TRPV1 from the TRP family: Structure, function, implication in autoimmune diseases and potential therapies","volume":"20","author":"Bejoma","year":"2026","journal-title":"Channels (Austin)"},{"key":"B15","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/978-3-642-54215-2_9","article-title":"TRPV1","volume":"222","author":"Bevan","year":"2014","journal-title":"Handb. Exp. Pharmacol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"14314","DOI":"10.3390\/ijms232214314","article-title":"The histamine H(4) receptor participates in the neuropathic pain-relieving activity of the histamine H(3) receptor antagonist GSK189254","volume":"23","author":"Borgonetti","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: a heat-activated ion channel in the pain pathway","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"B18","doi-asserted-by":"publisher","first-page":"756","DOI":"10.3390\/ph17060756","article-title":"TRPV1 channels in the central nervous system as drug targets","volume":"17","author":"Chahl","year":"2024","journal-title":"Pharm. (Basel)"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2025.107837","article-title":"A TRPV1 agonist from the transcriptome profiling of Dipsastraea rotumana inhibits neuroinflammation in vivo through the NF-\u03baB and MAPK pathways","volume":"218","author":"Chen","year":"2025","journal-title":"Pharmacol. Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.jointm.2024.01.008","article-title":"TRPV1: The key bridge in neuroimmune interactions","volume":"4","author":"Chen","year":"2024","journal-title":"J. Intensive Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.13406\/j.cnki.cyxb.003747","article-title":"Role of TRPV1-mediated microglia autophagy in postherpetic neuralgiaand molecular mechanism","volume":"50","author":"Chen","year":"2025","journal-title":"J. Chongqing Med. Univ."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24040775","article-title":"Long-term diabetic microenvironment augments the decay rate of capsaicin-induced currents in mouse dorsal root ganglion neurons","volume":"24","author":"Chen","year":"2019","journal-title":"Molecules"},{"key":"B23","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s00281-018-0675-z","article-title":"Skin neurogenic inflammation","volume":"40","author":"Choi","year":"2018","journal-title":"Semin. Immunopathol."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1549190","article-title":"Selenium reduces oxaliplatin induced neuropathic pain: focus on TRPV1","volume":"16","author":"\u00c7i\u011f","year":"2025","journal-title":"Front. Pharmacol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.npep.2006.06.002","article-title":"Effects of the neuropeptides substance P, calcitonin gene-related peptide, vasoactive intestinal polypeptide and galanin on the production of nerve growth factor and inflammatory cytokines in cultured human keratinocytes","volume":"40","author":"Dallos","year":"2006","journal-title":"Neuropeptides"},{"key":"B26","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/sj.jid.5700590","article-title":"Effects of skin surface temperature on epidermal permeability barrier homeostasis","volume":"127","author":"Denda","year":"2007","journal-title":"J. Invest. Dermatol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"83","DOI":"10.19917\/j.cnki.1005-0779.025118","article-title":"Study on action mechanism of fire acupuncture in modulating TRPV1 to alleviate herpes zoster neuropathic pain","volume":"41","author":"Deng","year":"2025","journal-title":"JCAM"},{"key":"B28","doi-asserted-by":"publisher","first-page":"18345","DOI":"10.1073\/pnas.1420252111","article-title":"\u03b1CGRP is essential for algesic exocytotic mobilization of TRPV1 channels in peptidergic nociceptors","volume":"111","author":"Devesa","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B29","doi-asserted-by":"publisher","first-page":"8593","DOI":"10.1523\/jneurosci.3993-14.2015","article-title":"Persistent nociception triggered by nerve growth factor (NGF) is mediated by TRPV1 and oxidative mechanisms","volume":"35","author":"Eskander","year":"2015","journal-title":"J. Neurosci."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.930964","article-title":"TRPV1 in chronic pruritus and pain: Soft modulation as a therapeutic strategy","volume":"15","author":"Fern\u00e1ndez-Carvajal","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/s41582-023-00777-3","article-title":"Pain-resolving immune mechanisms in neuropathic pain","volume":"19","author":"Fiore","year":"2023","journal-title":"Nat. Rev. Neurol."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.116765","article-title":"Structures of TRPV1 bound by hyperthermia-inducing analgesics","volume":"45","author":"Gao","year":"2026","journal-title":"Cell Rep."},{"key":"B34","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.pharmthera.2010.01.002","article-title":"Chemokines, neuronal-glial interactions, and central processing of neuropathic pain","volume":"126","author":"Gao","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2024.1400118","article-title":"The dual role of TRPV1 in peripheral neuropathic pain: pain switches caused by its sensitization or desensitization","volume":"17","author":"Gao","year":"2024","journal-title":"Front. Mol. Neurosci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.tips.2008.08.003","article-title":"Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1","volume":"29","author":"Gavva","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"8957","DOI":"10.1021\/acs.jcim.5c00991","article-title":"Integrative computational approaches for TRPV1 ion channel inhibitor discovery: An integrated machine learning, drug repurposing and molecular simulation approach","volume":"65","author":"Gonz\u00e1lez","year":"2025","journal-title":"J. Chem. Inf. Model."},{"key":"B37","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative activation of macrophages: mechanism and functions","volume":"32","author":"Gordon","year":"2010","journal-title":"Immunity"},{"key":"B38","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1007\/s13238-017-0395-5","article-title":"TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization","volume":"8","author":"Gouin","year":"2017","journal-title":"Protein Cell"},{"key":"B39","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1136\/thoraxjnl-2011-201443","article-title":"Transient receptor potential channels mediate the tussive response to prostaglandin E2 and bradykinin","volume":"67","author":"Grace","year":"2012","journal-title":"Thorax"},{"key":"B40","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.virol.2015.03.046","article-title":"Neuronal changes induced by varicella zoster virus in a rat model of postherpetic neuralgia","volume":"482","author":"Guedon","year":"2015","journal-title":"Virology"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1124\/jpet.106.116657","article-title":"Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1\/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor","volume":"321","author":"Gunthorpe","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B42","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1046\/j.1460-9568.1999.00503.x","article-title":"Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites","volume":"11","author":"Guo","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1614587","article-title":"Efficacy and safety of different medications compared for the treatment of postherpetic neuralgia: a network meta-analysis","volume":"16","author":"Guo","year":"2025","journal-title":"Front. Pharmacol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"319","DOI":"10.2340\/00015555-2247","article-title":"Transient receptor potential vanilloid-1 in epidermal keratinocytes may contribute to acute pain in herpes zoster","volume":"96","author":"Han","year":"2016","journal-title":"Acta Derm Venereol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3390\/ph18030363","article-title":"Cortical potentiation in chronic neuropathic pain and the future treatment","volume":"18","author":"Hao","year":"2025","journal-title":"Pharm. (Basel)"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1111\/exd.13705","article-title":"Possible roles of basophils in chronic itch","volume":"28","author":"Hashimoto","year":"2019","journal-title":"Exp. Dermatol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1016\/j.neuron.2024.02.016","article-title":"TRPV1 analgesics disturb core body temperature via a biased allosteric mechanism involving conformations distinct from that for nociception","volume":"112","author":"Huang","year":"2024","journal-title":"Neuron"},{"key":"B48","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s40265-020-01429-2","article-title":"TRPV1-targeted drugs in development for human pain conditions","volume":"81","author":"Iftinca","year":"2021","journal-title":"Drugs"},{"key":"B49","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1126\/science.aaf8924","article-title":"Pain regulation by non-neuronal cells and inflammation","volume":"354","author":"Ji","year":"2016","journal-title":"Science"},{"key":"B50","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1097\/aln.0000000000002130","article-title":"Neuroinflammation and central sensitization in chronic and widespread pain","volume":"129","author":"Ji","year":"2018","journal-title":"Anesthesiology"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1126\/stke.2522004re14","article-title":"Cell signaling and the genesis of neuropathic pain","volume":"2004","author":"Ji","year":"2004","journal-title":"Sci. STKE"},{"key":"B54","doi-asserted-by":"publisher","first-page":"5311","DOI":"10.2147\/jir.S472341","article-title":"Suppression of CGRP and TRPV1 expression in dorsal root ganglia of knee osteoarthritis rats by Huojing Decoction via TrkA\/MKK3\/6\/p38 pathway","volume":"17","author":"Jiang","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-026-01585-0","article-title":"Calpain cleaves the distal carboxyl terminus of TRPV1 and modulates its tachyphylaxis","author":"Jiang","year":"2026","journal-title":"Cell Biosci"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1615638","article-title":"S100A8\/A9 in herpes zoster neuralgia: molecular mechanisms and therapeutic perspectives","volume":"16","author":"Jiang","year":"2025","journal-title":"Front. Immunol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1146\/annurev-cellbio-101011-155833","article-title":"TRP channels and pain","volume":"29","author":"Julius","year":"2013","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104580","article-title":"The role of neutrophils in neuro-immune modulation","volume":"151","author":"Kanashiro","year":"2020","journal-title":"Pharmacol. Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1248\/bpb.34.1170","article-title":"Prostaglandin E2 and pain--an update","volume":"34","author":"Kawabata","year":"2011","journal-title":"Biol. Pharm. Bull."},{"key":"B58","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.neuron.2013.12.011","article-title":"Central terminal sensitization of TRPV1 by descending serotonergic facilitation modulates chronic pain","volume":"81","author":"Kim","year":"2014","journal-title":"Neuron"},{"key":"B59","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.bbi.2017.03.007","article-title":"Modulation of neuroinflammation: Role and therapeutic potential of TRPV1 in the neuro-immune axis","volume":"64","author":"Kong","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"B63","doi-asserted-by":"publisher","first-page":"12","DOI":"10.4103\/2045-9912.372666","article-title":"Ozonated autohemotherapy combined with pulsed radiofrequency in the treatment of thoracic postherpetic neuralgia in older adults: a retrospective study","volume":"14","author":"Li","year":"2024","journal-title":"Med. Gas Res."},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1645095","article-title":"Mast cell-neuron axis as a core mechanism in chronic pruritus of atopic dermatitis: from mechanistic insights to therapeutic targets","volume":"16","author":"Li","year":"2025","journal-title":"Front. Immunol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.14066\/j.cnki.cn21-1349\/r.2021.0079","article-title":"Transient potential vanillin receptor 1 and inflammatory pain","volume":"39","author":"Li","year":"2022","journal-title":"J. Shenyang Pharm. Univ."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.741054","article-title":"Change in Cav3.2 T-Type calcium channel induced by varicella-zoster virus participates in the maintenance of herpetic neuralgia","volume":"12","author":"Li","year":"2021","journal-title":"Front. Neurol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"596","DOI":"10.3390\/pathogens13070596","article-title":"Herpes zoster and post-herpetic neuralgia-diagnosis, treatment, and vaccination strategies","volume":"13","author":"Lim","year":"2024","journal-title":"Pathogens"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1631\/jzus.B2500209","article-title":"TRPV1: from structure to function-a multidimensional target for therapeutic advances","volume":"27","author":"Liu","year":"2026","journal-title":"J. Zhejiang Univ.-Sci. B"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13867","article-title":"Peripheral and central pathogenesis of postherpetic neuralgia","volume":"30","author":"Liu","year":"2024","journal-title":"Skin Res. Technol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s10616-025-00806-7","article-title":"S1P receptor 1 antagonist ponesimod alleviates postherpetic neuralgia in rats by normalizing spinal TRPV1 expression and inhibiting MAPK-mediated glial activation","volume":"77","author":"Liu","year":"2025","journal-title":"Cytotechnology"},{"key":"B68","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1002\/ejp.959","article-title":"Stimulating TRPV1 externalization and synthesis in dorsal root ganglion neurons contributes to PGE2 potentiation of TRPV1 activity and nociceptor sensitization","volume":"21","author":"Ma","year":"2017","journal-title":"Eur. J. Pain"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0323810","article-title":"Suppression of mechanical hypersensitivity and change in the expression of the dopamine D2 receptor by administration of anti-CGRP antibody into the trigeminal ganglion in trigeminal neuropathic pain model rats","volume":"20","author":"Maegawa","year":"2025","journal-title":"PloS One"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1007\/s00424-009-0703-x","article-title":"TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP","volume":"458","author":"Mandadi","year":"2009","journal-title":"Pflugers Arch."},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.808799","article-title":"Role of lactate in inflammatory processes: friend or foe","volume":"12","author":"Manosalva","year":"2021","journal-title":"Front. Immunol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"5001","DOI":"10.3390\/ijms24055001","article-title":"Molecular mechanisms of neurogenic inflammation of the skin","volume":"24","author":"Marek-Jozefowicz","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2024.102870","article-title":"TRPV1: Receptor structure, activation, modulation and role in neuro-immune interactions and pain","volume":"119","author":"Maximiano","year":"2024","journal-title":"Cell. Calcium"},{"key":"B74","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s10194-015-0539-z","article-title":"Two TRPV1 receptor antagonists are effective in two different experimental models of migraine","volume":"16","author":"Meents","year":"2015","journal-title":"J. Headache Pain"},{"key":"B75","doi-asserted-by":"publisher","first-page":"3655","DOI":"10.1073\/pnas.97.7.3655","article-title":"Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human","volume":"97","author":"Mezey","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B76","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1080\/14728222.2024.2416961","article-title":"Targeting the TRPV1 pain pathway in osteoarthritis of the knee","volume":"28","author":"Mobasheri","year":"2024","journal-title":"Expert Opin. Ther. Targets"},{"key":"B77","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1111\/bph.14044","article-title":"Targeting nociceptive transient receptor potential channels to treat chronic pain: current state of the field","volume":"175","author":"Moran","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/nn2027","article-title":"A thermosensory pathway that controls body temperature","volume":"11","author":"Nakamura","year":"2008","journal-title":"Nat. Neurosci."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1016\/j.celrep.2017.10.063","article-title":"Oxytocin modulates nociception as an agonist of pain-sensing TRPV1","volume":"21","author":"Nersesyan","year":"2017","journal-title":"Cell Rep."},{"key":"B80","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/978-1-4419-8056-4_10","article-title":"Histamine in neurotransmission and brain diseases","volume":"709","author":"Nuutinen","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"10203","DOI":"10.1128\/jvi.01331-12","article-title":"Restricted varicella-zoster virus transcription in human trigeminal ganglia obtained soon after death","volume":"86","author":"Ouwendijk","year":"2012","journal-title":"J. Virol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1159\/000513582","article-title":"Novel strategies to target mast cells in disease","volume":"13","author":"Paivandy","year":"2021","journal-title":"J.\u00a0Innate Immun."},{"key":"B83","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1097\/j.pain.0000000000000092","article-title":"Selective keratinocyte stimulation is sufficient to evoke nociception in mice","volume":"156","author":"Pang","year":"2015","journal-title":"Pain"},{"key":"B84","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.1126\/science.1073140","article-title":"A heat-sensitive TRP channel expressed in keratinocytes","volume":"296","author":"Peier","year":"2002","journal-title":"Science"},{"key":"B85","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.it.2016.10.001","article-title":"Nociceptor sensory neuron-immune interactions in pain and inflammation","volume":"38","author":"Pinho-Ribeiro","year":"2017","journal-title":"Trends Immunol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1080\/17581869.2024.2442292","article-title":"Novel non-opioid analgesics in pain management","volume":"14","author":"Pulskamp","year":"2024","journal-title":"Pain Manag"},{"key":"B87","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1111\/joa.12529","article-title":"TRPV1 receptor in the human trigeminal ganglion and spinal nucleus: immunohistochemical localization and comparison with the neuropeptides CGRP and SP","volume":"229","author":"Quartu","year":"2016","journal-title":"J. Anat."},{"key":"B88","doi-asserted-by":"publisher","first-page":"156","DOI":"10.3390\/ph17020156","article-title":"Functional analysis of TRPA1, TRPM3, and TRPV1 channels in human dermal arteries and their role in vascular modulation","volume":"17","author":"Rivera-Mancilla","year":"2024","journal-title":"Pharm. (Basel)"},{"key":"B89","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1152\/physrev.00026.2005","article-title":"Neuronal control of skin function: the skin as a neuroimmunoendocrine organ","volume":"86","author":"Roosterman","year":"2006","journal-title":"Physiol. Rev."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1152\/physrev.00059.2021","article-title":"CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond","volume":"103","author":"Russo","year":"2023","journal-title":"Physiol. Rev."},{"key":"B91","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1007\/s11033-025-10542-y","article-title":"Unraveling the role of CGRP in neurological diseases: a comprehensive exploration to pathological mechanisms and therapeutic implications","volume":"52","author":"Sarkar","year":"2025","journal-title":"Mol. Biol. Rep."},{"key":"B92","doi-asserted-by":"publisher","first-page":"6","DOI":"10.2174\/1570159x21666230808111908","article-title":"Peripheral neuroinflammation and pain: how acute pain becomes chronic","volume":"22","author":"Schumacher","year":"2024","journal-title":"Curr. Neuropharmacol."},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.31083\/jin25829","article-title":"The role of cytokines in postherpetic neuralgia","volume":"24","author":"Shen","year":"2025","journal-title":"J. Integr. Neurosci."},{"key":"B94","doi-asserted-by":"publisher","first-page":"1","DOI":"10.12968\/hmed.2024.0485","article-title":"Effectiveness and safety of gabapentin versus pregabalin in the treatment of postherpetic neuralgia: a retrospective cohort study","volume":"85","author":"Shi","year":"2024","journal-title":"Br. J. Hosp. Med. (Lond)"},{"key":"B95","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1523\/jneurosci.4643-06.2007","article-title":"TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase","volume":"27","author":"Shim","year":"2007","journal-title":"J. Neurosci."},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13275","article-title":"Functional validation of co-culture model of human keratinocytes and neuronal cell line for sensitive skin by using transient receptor potential channel vanilloid subfamily member 1 antagonist","volume":"29","author":"Shin","year":"2023","journal-title":"Skin Res. Technol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.bbrc.2021.10.046","article-title":"Mechanical stimulus-evoked signal transduction between keratinocytes and sensory neurons via extracellular ATP","volume":"582","author":"Shindo","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171366","article-title":"Analysis of TRPV channel activation by stimulation of FC\u03f5RI and MRGPR receptors in mouse peritoneal mast cells","volume":"12","author":"Sol\u00eds-L\u00f3pez","year":"2017","journal-title":"PloS One"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5806321","article-title":"Multifunctional TRPV1 ion channels in physiology and pathology with focus on the brain, vasculature, and some visceral systems","volume":"2019","author":"Storozhuk","year":"2019","journal-title":"BioMed. Res. Int."},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2020.151565","article-title":"Changes in TRPV1 expression in the POA of ovariectomized rats regulated by NE-dependent \u03b12-ADR may be involved in hot flashes","volume":"232","author":"Sun","year":"2020","journal-title":"Ann. Anat."},{"key":"B101","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/s0031-6997(24)01403-0","article-title":"Vanilloid (Capsaicin) receptors and mechanisms","volume":"51","author":"Szallasi","year":"1999","journal-title":"Pharmacol. Rev."},{"key":"B102","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s13238-019-00683-9","article-title":"Lifting the veil on the keratinocyte contribution to cutaneous nociception","volume":"11","author":"Talagas","year":"2020","journal-title":"Protein Cell"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6679348","article-title":"Tongxie Anchang Decoction relieves visceral hypersensitivity in diarrhea-predominant irritable bowel syndrome rats by regulating the NGF\/TrkA signaling pathway","volume":"2021","author":"Tan","year":"2021","journal-title":"Evid Based Complement Alternat Med."},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1700282","article-title":"Brain TRPV1 channel-mediated calcium influx: the immunomodulatory pathway of acupuncture in neuroinflammation","volume":"16","author":"Tang","year":"2025","journal-title":"Front. Immunol."},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2024.156813","article-title":"The role of macrophages in chronic pain","volume":"185","author":"Tang","year":"2025","journal-title":"Cytokine"},{"key":"B106","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.jid.2018.10.011","article-title":"Thromboxane-induced \u03b1-CGRP release from peripheral neurons is an essential positive feedback loop in capsaicin-induced neurogenic inflammation","volume":"139","author":"Tarighi","year":"2019","journal-title":"J. Invest. Dermatol."},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphyss.2025.100009","article-title":"TRPV1 and thermosensitivity","volume":"75","author":"Tominaga","year":"2025","journal-title":"J. Physiol. Sci."},{"key":"B108","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1113\/jphysiol.1992.sp019069","article-title":"Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans","volume":"448","author":"Torebj\u00f6rk","year":"1992","journal-title":"J. Physiol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"12365","DOI":"10.3390\/ijms222212365","article-title":"Connections between immune-derived mediators and sensory nerves for itch sensation","volume":"22","author":"Toyama","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B110","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/nn.3881","article-title":"Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing","volume":"18","author":"Usoskin","year":"2015","journal-title":"Nat. Neurosci."},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12677","article-title":"The importance of the neuro-immuno-cutaneous system on human skin equivalent design","volume":"52","author":"Vidal Yucha","year":"2019","journal-title":"Cell. Prolif"},{"key":"B112","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.cell.2020.12.033","article-title":"A basophil-neuronal axis promotes itch","volume":"184","author":"Wang","year":"2021","journal-title":"Cell"},{"key":"B114","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.3390\/ijerph19042387","article-title":"Side effects of opioids are ameliorated by regulating TRPV1 receptors","volume":"19","author":"Wang","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"B113","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1097\/j.pain.0000000000000134","article-title":"Modality-specific mechanisms of protein kinase C-induced hypersensitivity of TRPV1: S800 is a polymodal sensitization site","volume":"156","author":"Wang","year":"2015","journal-title":"Pain"},{"key":"B115","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.expneurol.2015.12.002","article-title":"Involvement of aberrant calcium signalling in herpetic neuralgia","volume":"277","author":"Warwick","year":"2016","journal-title":"Exp. Neurol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"4805","DOI":"10.2147\/ijgm.S480411","article-title":"Validity of plasma neuropeptide Y in combination with clinical factors in predicting neuralgia following herpes zoster","volume":"17","author":"Wu","year":"2024","journal-title":"Int. J. Gen. Med."},{"key":"B117","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3969\/j.issn.1006-9852.2023.02.002","article-title":"New progress in animal model and mechanism of postherpetic neuralgia","volume":"29","author":"Wu","year":"2023","journal-title":"Chin. J. Pain Med."},{"key":"B118","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1007\/978-94-007-0265-3_34","article-title":"TRPV1: a therapy target that attracts the pharmaceutical interests","volume":"704","author":"Xia","year":"2011","journal-title":"Adv. Exp. Med. Biol."},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2025.108005","article-title":"Epidemiology of herpes zoster and post-herpetic neuralgia in China: A nationwide population-based survey","volume":"159","author":"Xia","year":"2025","journal-title":"Int. J. Infect. Dis."},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1037925","article-title":"TRPV1: a promising therapeutic target for skin aging and inflammatory skin diseases","volume":"14","author":"Xiao","year":"2023","journal-title":"Front. Pharmacol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1038\/s41598-024-82121-3","article-title":"SIX1 aggravates the progression of spinal cord injury in mice by promoting M1 polarization of microglia","volume":"15","author":"Xu","year":"2025","journal-title":"Sci. Rep."},{"key":"B122","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s40122-019-0127-z","article-title":"The epidemiology of herpes zoster and postherpetic neuralgia in China: Results from a cross-sectional study","volume":"8","author":"Yang","year":"2019","journal-title":"Pain Ther."},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00538","article-title":"The effectiveness and safety of topical capsaicin in postherpetic neuralgia: A systematic review and meta-analysis","volume":"7","author":"Yong","year":"2016","journal-title":"Front. Pharmacol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1016\/j.jaci.2018.09.005","article-title":"Itch: From mechanism to (novel) therapeutic approaches","volume":"142","author":"Yosipovitch","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/nm.3804","article-title":"The ketone metabolite \u03b2-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease","volume":"21","author":"Youm","year":"2015","journal-title":"Nat. Med."},{"key":"B126","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s12031-019-01352-6","article-title":"Inhibition of mast cell degranulation relieves visceral hypersensitivity induced by pancreatic carcinoma in mice","volume":"69","author":"Yu","year":"2019","journal-title":"J. Mol. Neurosci."},{"key":"B127","doi-asserted-by":"publisher","first-page":"887","DOI":"10.2147\/jpr.S449211","article-title":"Humoral cytokine levels in patients with herpes zoster: A meta-analysis","volume":"17","author":"Yue","year":"2024","journal-title":"J. Pain Res."},{"key":"B128","doi-asserted-by":"publisher","first-page":"6490","DOI":"10.1073\/pnas.0501045102","article-title":"Varicella-zoster virus infection of human dorsal root ganglia in vivo","volume":"102","author":"Zerboni","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02495-x","article-title":"DKK3 ameliorates neuropathic pain via inhibiting ASK-1\/JNK\/p-38-mediated microglia polarization and neuroinflammation","volume":"19","author":"Zhang","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"B130","doi-asserted-by":"publisher","first-page":"5138","DOI":"10.1016\/j.cell.2021.08.012","article-title":"Structural snapshots of TRPV1 reveal mechanism of polymodal functionality","volume":"184","author":"Zhang","year":"2021","journal-title":"Cell"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34817-1","article-title":"Structure-guided peptide engineering of a positive allosteric modulator targeting the outer pore of TRPV1 for long-lasting analgesia","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat. Commun."},{"key":"B132","doi-asserted-by":"publisher","first-page":"508","DOI":"10.13200\/j.cnki.cjb.004463","article-title":"Research progress on epidemiological characteristics andprevention of herpes zoster in China","volume":"38","author":"Zhou","year":"2025","journal-title":"Chin. J. Biologicals"},{"key":"B133","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.3390\/cells14151146","article-title":"Molecular mechanisms and pathways in visceral pain","volume":"14","author":"Zhou","year":"2025","journal-title":"Cells"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115806","article-title":"Progress in the development of TRPV1 small-molecule antagonists: Novel strategies for pain management","volume":"261","author":"Zhu","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"B135","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.neuron.2004.12.015","article-title":"Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd","volume":"45","author":"Zylka","year":"2005","journal-title":"Neuron"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2026.1841790\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T04:47:01Z","timestamp":1784090821000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2026.1841790\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,15]]},"references-count":135,"alternative-id":["10.3389\/fcimb.2026.1841790"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2026.1841790","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,15]]},"article-number":"1841790"}}