{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:59:22Z","timestamp":1785473962854,"version":"3.56.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Non-coding RNAs (ncRNAs) have emerged as critical regulators in host\u2013parasite interactions, yet the rapid proliferation of publications has made it challenging to obtain a comprehensive, unbiased view of the field\u2019s intellectual structure and evolving frontiers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a bibliometric analysis of research articles on ncRNAs in parasitic diseases published from 2015 to 2025.\u00a0A multi\u2212database search was conducted across the Web of Science Core Collection, PubMed, and the Cochrane Library, yielding 432 records for annual publication trend analysis, with 409 original research articles from the Web of Science Core Collection used for bibliometric network analyses, including co\u2212citation, collaboration networks, keyword clustering, burst detection, and dual\u2212map overlay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Annual publications grew steadily from 21 to 44 over the decade, with a peak of 51 in 2022. China ranked first in output (175 articles), while the United States showed the highest centrality (0.37). Author collaboration networks were sparse (density = 0.0032), indicating fragmented research efforts. Keyword clustering identified 11 clusters, with \u201cliver\u201d and \u201cimmune responses\u201d as persistent core themes; \u201cextracellular vesicles\u201d emerged as a key hub after 2018. Citation burst analysis revealed a three\u2212phase evolution\u2014from molecular identification (2015\u20132019) to functional regulation and communication (2019\u20132021), and then to host\u2013pathogen interactions and translational applications (2022\u20132025). The most highly cited references collectively established the \u201cextracellular vesicles\u2013ncRNA\u201d paradigm, and persistently bursting references point toward clinical diagnostics. Circular RNAs and the NF\u2212\u03baB pathway appeared as emerging hotspots. Journal overlay mapping showed knowledge flowing from molecular biology toward veterinary and parasitology disciplines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The field is transitioning from fundamental discovery toward translational applications, with extracellular vesicle\u2212encapsulated ncRNAs holding promise as biomarkers and therapeutic targets. Enhanced international collaboration and interdisciplinary integration are urgently needed to accelerate progress.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1841931","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:25:25Z","timestamp":1785471925000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Non-coding RNAs in parasitic diseases: a bibliometric analysis of knowledge structure, research hotspots, and future directions"],"prefix":"10.3389","volume":"16","author":[{"given":"Xin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Minimally Invasive Spine Surgery and Precision Orthopedics, The First Affiliated Hospital of Xinjiang Medical University","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xinjiang Engineering Technology Research Center for Medicine-Industry Integration, Xinjiang Medical University","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma, the First Affiliated Hospital of Xinjiang Medical University","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Minimally Invasive Spine Surgery and Precision Orthopedics, The First Affiliated Hospital of Xinjiang Medical University","place":["Urumqi, China"]},{"name":"Xinjiang Engineering Technology Research Center for Medicine-Industry Integration, Xinjiang Medical University","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical Laboratory Center, The First Affiliated Hospital of Xinjiang Medical University","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"Xinjiang Engineering Technology Research Center for Medicine-Industry Integration, Xinjiang Medical University","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Minimally Invasive Spine Surgery and Precision Orthopedics, The First Affiliated Hospital of Xinjiang Medical University","place":["Urumqi, China"]},{"name":"Xinjiang Engineering Technology Research Center for Medicine-Industry Integration, Xinjiang Medical University","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengru","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma, the First Affiliated Hospital of Xinjiang Medical University","place":["Urumqi, China"]},{"name":"Key Laboratory of High Incidence Disease Research in Xingjiang (Xinjiang Medical University), Ministry of Education","place":["Urumqi, China"]},{"name":"Xinjiang Clinical Research Center for Orthopedics, Xinjiang Medical University","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Minimally Invasive Spine Surgery and Precision Orthopedics, The First Affiliated Hospital of Xinjiang Medical University","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Minimally Invasive Spine Surgery and Precision Orthopedics, The First Affiliated Hospital of Xinjiang Medical University","place":["Urumqi, China"]},{"name":"Xinjiang Engineering Technology Research Center for Medicine-Industry Integration, Xinjiang Medical University","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2019.105255","article-title":"Parasite-derived microRNAs in plasma as novel promising biomarkers for the early detection of hydatid cyst infection and post-surgery follow-up","volume":"202","author":"Alizadeh","year":"2020","journal-title":"Acta Trop."},{"key":"B2","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/bs.apar.2023.02.001","article-title":"Food- and vector-borne parasitic zoonoses: global burden and impacts","volume":"120","author":"Anisuzzaman","year":"2023","journal-title":"Adv. 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