{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T07:02:08Z","timestamp":1779778928634,"version":"3.53.1"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    is an important opportunistic pathogen. In the immunocompromised people,\n                    <jats:italic>A. fumigatus<\/jats:italic>\n                    infection can cause invasive aspergillosis, which is characterized by high incidence rate and high mortality. However, due to the limited availability of anti-fungal drugs and the continuous emergence of drug-resistant strains, the treatment of\n                    <jats:italic>A. fumigatus<\/jats:italic>\n                    infection is facing enormous challenges. 5-nitro-8-hydroxyquinoline (NQ) is an ancient antibiotic and pharmaceutical intermediate and fungicide, which is not only exhibits good antibacterial activity on against drug-resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ,\n                    <jats:italic>Candida<\/jats:italic>\n                    spp., but also has good biofilm eradication on activity against\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    ,\n                    <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                    . However, it is not known whether NQ has anti-\n                    <jats:italic>A. fumigatus<\/jats:italic>\n                    infection effects\n                    <jats:italic>in vivo<\/jats:italic>\n                    . This study evaluates the\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    activity of NQ against\n                    <jats:italic>A. fumigatus<\/jats:italic>\n                    . The results showed that NQ not only had a good anti-\n                    <jats:italic>A. fumigatus<\/jats:italic>\n                    effect, but also promoted the phagocytosis and killing ability of alveolar macrophages to\n                    <jats:italic>A. fumigatus<\/jats:italic>\n                    . In addition, we found that intraperitoneal injection of NQ significantly reduced the diffuse infection degree of\n                    <jats:italic>A. fumigatus<\/jats:italic>\n                    and the fungal burden in mice tissues, and increased the secretion of IL-2, IL-6, IL-10 in the blood. NQ exerted a good anti-fungal effect. In summary, these results confirm that NQ may be a potential anti-fungal drug for treating\n                    <jats:italic>A. fumigatus<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2026.1843404","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T06:02:27Z","timestamp":1779775347000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The therapeutic effect of 5-nitro-8-hydroxyquinoline on Aspergillus fumigatus: results from in vitro and in vivo models of invasive aspergillosis"],"prefix":"10.3389","volume":"16","author":[{"given":"Jiyu","family":"Ran","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, The Affiliated Yongchuan Hospital of Chongqing Medical University, School of Basic Medical Sciences, Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Zhou","sequence":"additional","affiliation":[{"name":"Tuberculosis Reference Laboratory, Chongqing Tuberculosis Control Institute","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Affiliated Yongchuan Hospital of Chongqing Medical University, School of Basic Medical Sciences, Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanrong","family":"Huan","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Affiliated Yongchuan Hospital of Chongqing Medical University, School of Basic Medical Sciences, Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Affiliated Yongchuan Hospital of Chongqing Medical University, School of Basic Medical Sciences, Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeng","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Affiliated Yongchuan Hospital of Chongqing Medical University, School of Basic Medical Sciences, Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.ijantimicag.2016.10.017","article-title":"Nitroxoline: a broad-spectrum biofilm-eradicating agent against pathogenic bacteria","volume":"49","author":"Abouelhassan","year":"2017","journal-title":"Int. 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