{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:37:49Z","timestamp":1787981869458,"version":"build-2784847793"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      (\n                      <jats:italic>H. pylori<\/jats:italic>\n                      ) is a major cause of gastric cancer (GC); however, GC also develops in\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2013negative patients, and the characteristics of non-\n                      <jats:italic>H. pylori<\/jats:italic>\n                      microbial communities remain unclear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We characterized gastric microbiota in patients with GC according to\n                      <jats:italic>H. pylori<\/jats:italic>\n                      status, sex, GC subtype, and longitudinal changes following\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication therapy. Gastric corpus mucosal samples were collected from 35 patients with GC who underwent endoscopic therapy and longitudinal follow-up. Some patients were followed for more than 10 years, and gastric microbiota were analyzed using 16S rRNA gene sequencing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2013negative samples exhibited significantly higher microbial diversity and distinct community structures compared with\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2013positive samples, which was consistent across sex and GC subtypes. Multiple non-\n                      <jats:italic>H. pylori<\/jats:italic>\n                      taxa were enriched in\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2013negative samples, including organisms with reported urease and nitrate-reducing activities. Longitudinal analyses demonstrated that successful eradication induced significant but non-uniform microbial shifts, whereas persistent infection maintained stable\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2013dominated profiles. Notably, species-level analyses revealed selective and\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication-specific microbial changes, with\n                      <jats:italic>Actinomyces naeslundii<\/jats:italic>\n                      consistently enriched only in the\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradicated group across longitudinal modeling and differential abundance analyses. Functional prediction analyses revealed a reduced representation of host\u2013pathogen interaction\u2013related pathways in\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2013negative samples.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      These findings suggest that\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2013negative gastric microbiota harbor functionally distinct microbial communities that may contribute to gastric carcinogenesis through alternative microbial and ecological pathways. In addition,\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication revealed a longitudinal remodeling of gastric microbiota.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1848437","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:40:51Z","timestamp":1780638051000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Longitudinal remodeling of gastric microbiota following Helicobacter pylori eradication reveals an eradication-associated microbial signature in gastric cancer"],"prefix":"10.3389","volume":"16","author":[{"given":"Chin-Hee","family":"Song","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Bundang Hospital","place":["Seongnam, Republic of Korea"]},{"name":"Research Center for Sex- and Gender-Specific Medicine, Seoul National University Bundang Hospital","place":["Seongnam, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghoon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Bundang Hospital","place":["Seongnam, Republic of Korea"]},{"name":"Research Center for Sex- and Gender-Specific Medicine, Seoul National University Bundang Hospital","place":["Seongnam, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Bundang Hospital","place":["Seongnam, Republic of Korea"]},{"name":"Research Center for Sex- and Gender-Specific Medicine, Seoul National University Bundang Hospital","place":["Seongnam, Republic of Korea"]},{"name":"Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungchan","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Bundang Hospital","place":["Seongnam, Republic of Korea"]},{"name":"Research Center for Sex- and Gender-Specific Medicine, Seoul National University Bundang Hospital","place":["Seongnam, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Kyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Bundang Hospital","place":["Seongnam, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol Min","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Bundang Hospital","place":["Seongnam, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyeon","family":"Ahn","sequence":"additional","affiliation":[{"name":"Medical Research Collaborating Center, Seoul National University Bundang Hospital","place":["Seongnam, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1053\/j.gastro.2015.09.004","article-title":"Pathobiology of Helicobacter pylori-induced gastric cancer","volume":"150","author":"Amieva","year":"2016","journal-title":"Gastroenterology"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/srep04202","article-title":"Stomach microbiota composition varies between patients with non-atrophic gastritis and patients with intestinal type of gastric cancer","volume":"4","author":"Aviles-Jimenez","year":"2014","journal-title":"Sci. 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