{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:16:26Z","timestamp":1783487786990,"version":"3.55.0"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to investigate t-PAIC concentration changes across severity levels in HFRS patients and evaluate its value in predicting disease severity, providing a potential biomarker for HFRS severity assessment and monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>t-PAIC levels were measured by chemiluminescence immunoassay in 156 HFRS patients and 37 healthy controls. Routine laboratory tests assessed WBC, PLT, Cr, UA, urea, HDL, ALB, APTT, and PT. HFRS-specific antibodies were detected using the colloidal gold method. Spearman correlation analysis evaluated associations between t-PAIC and clinical indices. Ordinal logistic regression identified risk factors linked to disease severity. ROC curve analysis assessed the predictive performance of t-PAIC for HFRS severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      t-PAIC levels progressively increased with HFRS severity, peaking in critically ill patients. t-PAIC showed significant positive correlations with leukocyte count (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.6082;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.01), Cr (\n                      <jats:italic>r<\/jats:italic>\n                      =\u00a00.3567;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.01), urea (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.4376;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.01), UA (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.3201;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.01), APTT (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.6182;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.01), and PT (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.2997;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.01), and significant inverse correlations with PLT (\n                      <jats:italic>r<\/jats:italic>\n                      = \u22120.6177;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.01), HDL (\n                      <jats:italic>r<\/jats:italic>\n                      = \u22120.3074;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.01), and ALB (\n                      <jats:italic>r<\/jats:italic>\n                      = \u22120.4790;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.01). ROC analysis revealed t-PAIC had good predictive value for disease severity (AUC\u00a0=\u00a00.796, 95%\n                      <jats:italic>CI<\/jats:italic>\n                      : 0.724\u20130.867,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>t-PAIC levels closely reflect HFRS severity and associated clinical features, including renal dysfunction and coagulation abnormalities, suggesting its potential as a biomarker for monitoring disease status.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1849586","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:46:09Z","timestamp":1783485969000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["t-PA\/PAI-1 complex expression correlates with the severity in hantaan virus-induced hemorrhagic fever with renal syndrome"],"prefix":"10.3389","volume":"16","author":[{"given":"Han-Dong","family":"Zhao","sequence":"first","affiliation":[{"name":"Central Laboratory of Virology, Shaanxi Provincial Hospital of Infectious Diseases, The Xi\u2019an Eighth Hospital","place":["Xi\u2019an, China"]},{"name":"Clinical Laboratory Center, Shaanxi Provincial Hospital of Infectious Diseases, The Xi\u2019an Eighth Hospital","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei-Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Shaanxi Provincial Clinical Medical Research Center of Infectious Diseases, Shaanxi Provincial Hospital of Infectious Diseases, The Xi\u2019an Eighth Hospital","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Bo","family":"Qian","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Center, Shaanxi Provincial Hospital of Infectious Diseases, The Xi\u2019an Eighth Hospital","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Long","family":"Wang","sequence":"additional","affiliation":[{"name":"Section of Science and Education, Shaanxi Provincial Hospital of Infectious Diseases, The Xi\u2019an Eighth Hospital","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang-Xiao","family":"Ma","sequence":"additional","affiliation":[{"name":"Shaanxi Provincial Clinical Medical Research Center of Infectious Diseases, Shaanxi Provincial Hospital of Infectious Diseases, The Xi\u2019an Eighth Hospital","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Center, Xi\u2019an People\u2019s Hospital (Xi\u2019an Fourth Hospital), Affiliated Hospital of Northwest University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1111\/j.1742-1241.2005.00379.x","article-title":"Pivotal role of plasminogen-activator inhibitor 1 in vascular disease","volume":"59","author":"Agirbasli","year":"2005","journal-title":"Int. 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