{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:13:20Z","timestamp":1788416000316,"version":"build-2803163510"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014717","name":"Youth Science Fund Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n                      (\n                      <jats:italic>F. nucleatum<\/jats:italic>\n                      ) is increasingly recognized as a key pathobiont in colorectal cancer (CRC), driving tumor progression through immune evasion, inflammation, and metabolic reprogramming. Nevertheless, a comprehensive bibliometric analysis of the literature on\n                      <jats:italic>F. nucleatum<\/jats:italic>\n                      and CRC remains a gap in the current research landscape. Here, we integrate bibliometric trend analysis with a narrative synthesis of key mechanistic insights. Unlike traditional narrative reviews, this study systematically quantifies global research trends, collaboration networks, and thematic evolution using integrated bibliometric tools (CiteSpace, VOSviewer, and Bibliometrix).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study employed bibliometric analysis to explore the current status of research related to\n                      <jats:italic>F. nucleatum<\/jats:italic>\n                      and CRC. Publications from 2000 to 2025 were retrieved from the Web of Science Core Collection (WOSCC) and Scopus. We used VOSviewer, CiteSpace and Bibliometrix to visualize countries, institutions, authors, keywords, journals and references. Statistical analysis was conducted using Microsoft Office Excel.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The annual number of publications and their relative percentages concerning\n                      <jats:italic>F. nucleatum<\/jats:italic>\n                      and CRC exhibited a steady upward trend from 2009 to 2025, with China (n=708), the United States (n=584), and Italy(n=119) dominating the field. Harvard University and Shanghai Jiao Tong University emerged as leading institutions, while Yu Jun and Shuji Ogino were the most prolific authors. Keyword analysis identified 7 clusters. The most popular journal in this field is Gut. Limitations include potential selection bias from using only two databases (WOSCC and Scopus) and restriction to English-language publications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our research provides a comprehensive overview of the research trends and key focal areas in the study of\n                      <jats:italic>F. nucleatum<\/jats:italic>\n                      and CRC. The analysis results show that the annual publication volume in this field has steadily increased, indicating that researchers\u2019 attention to this topic has grown continuously. Future research directions suggested by the literature include further exploration of\n                      <jats:italic>F.\u00a0nucleatum<\/jats:italic>\n                      -targeted therapies, biomarker validation, and multi-omics approaches, although these remain at an early stage.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1851307","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:21:56Z","timestamp":1788412916000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Global research trends in Fusobacterium nucleatum and colorectal cancer: a bibliometric and visual analysis"],"prefix":"10.3389","volume":"16","author":[{"given":"Guanhua","family":"Lyu","sequence":"first","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingge","family":"Yue","sequence":"additional","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfei","family":"Duan","sequence":"additional","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhao","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.chom.2016.07.006","article-title":"Fap2 mediates Fusobacterium nucleatum colorectal adenocarcinoma enrichment by binding to tumor-expressed Gal-GalNAc","volume":"20","author":"Abed","year":"2016","journal-title":"Cell Host Microbe"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.102129","article-title":"Neuropsychiatric disturbances in mild cognitive impairment: a scientometric analysis","volume":"92","author":"Amrapala","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"B3","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1136\/gutjnl-2015-310912","article-title":"Global patterns and trends in colorectal cancer incidence and mortality","volume":"66","author":"Arnold","year":"2017","journal-title":"Gut"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2816","DOI":"10.1158\/1078-0432.CCR-20-4009","article-title":"Association of Fusobacterium nucleatum with specific T-cell subsets in the colorectal carcinoma microenvironment","volume":"27","author":"Borowsky","year":"2021","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1987780","article-title":"Fusobacterium nucleatum drives a pro-inflammatory intestinal microenvironment through metabolite receptor-dependent modulation of IL-17 expression","volume":"13","author":"Brennan","year":"2021","journal-title":"Gut Microbes"},{"key":"B6","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/s41579-018-0129-6","article-title":"Fusobacterium nucleatum - symbiont, opportunist and oncobacterium","volume":"17","author":"Brennan","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/s41416-018-0264-x","article-title":"The colorectal cancer epidemic: challenges and opportunities for primary, secondary and tertiary prevention","volume":"119","author":"Brenner","year":"2018","journal-title":"Br. J. Cancer"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1126\/science.aal5240","article-title":"Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer","volume":"358","author":"Bullman","year":"2017","journal-title":"Science"},{"key":"B9","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1101\/gr.126516.111","article-title":"Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma","volume":"22","author":"Castellarin","year":"2012","journal-title":"Genome Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jconrel.2023.09.028","article-title":"Delivery of short chain fatty acid butyrate to overcome Fusobacterium nucleatum-induced chemoresistance","volume":"363","author":"Chen","year":"2023","journal-title":"J. Control. Release Off. J. Control. Release Soc"},{"key":"B11","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1002\/jso.24578","article-title":"Colorectal cancer-global burden, trends, and geographical variations","volume":"115","author":"Douaiher","year":"2017","journal-title":"J. Surg. Oncol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1096\/fj.07-9492LSF","article-title":"Comparison of PubMed, Scopus, Web of Science, and Google Scholar: strengths and weaknesses","volume":"22","author":"Falagas","year":"2008","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc Exp. Biol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"368","DOI":"10.3390\/cancers17030368","article-title":"Unraveling the role of Fusobacterium nucleatum in colorectal cancer: molecular mechanisms and pathogenic insights","volume":"17","author":"Galasso","year":"2025","journal-title":"Cancers"},{"key":"B14","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.joim.2023.06.006","article-title":"Phytochemical interventions for post-traumatic stress disorder: a cluster co-occurrence network analysis using CiteSpace","volume":"21","author":"Gao","year":"2023","journal-title":"J. Integr. Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1126\/science.aaw2367","article-title":"The gut microbiota and colon cancer","volume":"364","author":"Garrett","year":"2019","journal-title":"Science"},{"key":"B16","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.immuni.2015.01.010","article-title":"Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack","volume":"42","author":"Gur","year":"2015","journal-title":"Immunity"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2019.1581531","article-title":"Fusobacterium nucleatum supresses anti-tumor immunity by activating CEACAM1","volume":"8","author":"Gur","year":"2019","journal-title":"Oncoimmunology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1158\/2326-6066.CIR-18-0174","article-title":"Fusobacterium nucleatum in colorectal cancer relates to immune response differentially by tumor microsatellite instability status","volume":"6","author":"Hamada","year":"2018","journal-title":"Cancer Immunol. Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of cancer: new dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"key":"B20","doi-asserted-by":"publisher","first-page":"3170","DOI":"10.1002\/cncr.34338","article-title":"Fusobacterium nucleatum impairs DNA mismatch repair and stability in patients with squamous cell carcinoma of the head and neck","volume":"128","author":"Hsueh","year":"2022","journal-title":"Cancer"},{"key":"B21","doi-asserted-by":"publisher","first-page":"23337","DOI":"10.18632\/aging.104188","article-title":"Intratumoral levels and prognostic significance of Fusobacterium nucleatum in cervical carcinoma","volume":"12","author":"Huang","year":"2020","journal-title":"Aging"},{"key":"B22","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/s41579-025-01237-z","article-title":"Fusobacterium nucleatum: ecology, pathogenesis and clinical implications","volume":"24","author":"Jiang","year":"2026","journal-title":"Nat. Rev. Microbiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.chom.2023.04.010","article-title":"Fusobacterium nucleatum-derived succinic acid induces tumor resistance to immunotherapy in colorectal cancer","volume":"31","author":"Jiang","year":"2023","journal-title":"Cell Host Microbe"},{"key":"B24","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1080\/08039480801961667","article-title":"How to use bibliometric methods in evaluation of scientific research? An example from Finnish schizophrenia research","volume":"62","author":"Koskinen","year":"2008","journal-title":"Nord. J. Psychiatry"},{"key":"B25","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.chom.2013.07.007","article-title":"Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment","volume":"14","author":"Kostic","year":"2013","journal-title":"Cell Host Microbe"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2024.0233","article-title":"Analysis of three-dimensional printing strategies for meniscus\/articular disc repair and regeneration","author":"Li","year":"2024","journal-title":"Tissue Eng. Part. B. Rev"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202105222","article-title":"Fusobacterium nucleatum promotes colorectal cancer cell to acquire stem cell-like features by manipulating lipid droplet-mediated Numb degradation","volume":"9","author":"Liu","year":"2022","journal-title":"Adv. Sci. Weinh. Baden-Wurtt. Ger."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2021.113932","article-title":"Frontier and hot topics in electrochemiluminescence sensing technology based on CiteSpace bibliometric analysis","volume":"201","author":"Liu","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1136\/gutjnl-2015-310101","article-title":"Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis","volume":"65","author":"Mima","year":"2016","journal-title":"Gut"},{"key":"B30","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1001\/jamaoncol.2015.1377","article-title":"Fusobacterium nucleatum and T cells in colorectal carcinoma","volume":"1","author":"Mima","year":"2015","journal-title":"JAMA Oncol."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11092358","article-title":"The role of Fusobacterium nucleatum in oral and colorectal carcinogenesis","volume":"11","author":"Pignatelli","year":"2023","journal-title":"Microorganisms"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e609","DOI":"10.1016\/S2214-109X(16)30143-7","article-title":"Global burden of cancers attributable to infections in 2012: a synthetic analysis","volume":"4","author":"Plummer","year":"2016","journal-title":"Lancet Glob. Health"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7010014","article-title":"What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet, and diseases","volume":"7","author":"Rinninella","year":"2019","journal-title":"Microorganisms"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201847638","article-title":"Fusobacterium nucleatum promotes colorectal cancer by inducing Wnt\/\u03b2-catenin modulator Annexin A1","volume":"20","author":"Rubinstein","year":"2019","journal-title":"EMBO Rep."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc4552","article-title":"The microbiome and human cancer","volume":"371","author":"Sepich-Poore","year":"2021","journal-title":"Science"},{"key":"B36","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA. Cancer J. Clin."},{"key":"B37","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/s42255-022-00558-0","article-title":"The gut microbial metabolite formate exacerbates colorectal cancer progression","volume":"4","author":"Ternes","year":"2022","journal-title":"Nat. Metab."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1053\/j.gastro.2024.07.040","article-title":"An empirical dietary pattern associated with the gut microbial features in relation to colorectal cancer risk","volume":"167","author":"Wang","year":"2024","journal-title":"Gastroenterology"},{"key":"B39","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.ccell.2025.02.023","article-title":"Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer","volume":"43","author":"Wang","year":"2025","journal-title":"Cancer Cell."},{"key":"B40","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/s41591-019-0406-6","article-title":"Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer","volume":"25","author":"Wirbel","year":"2019","journal-title":"Nat. Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/s41571-023-00766-x","article-title":"Gut microbiota in colorectal cancer development and therapy","volume":"20","author":"Wong","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1038\/s41575-019-0209-8","article-title":"Gut microbiota in colorectal cancer: mechanisms of action and clinical applications","volume":"16","author":"Wong","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1160048","article-title":"Knowledge mapping of immune thrombocytopenia: a bibliometric study","volume":"14","author":"Wu","year":"2023","journal-title":"Front. Immunol."},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1795703","article-title":"Microbe-driven immune suppression in colorectal cancer: the Fusobacterium nucleatum playbook","volume":"17","author":"Wuyi","year":"2026","journal-title":"Front. Immunol."},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2021.101174","article-title":"Global colorectal cancer burden in 2020 and projections to 2040","volume":"14","author":"Xi","year":"2021","journal-title":"Transl. Oncol."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1980347","article-title":"Fusobacterium nucleatum promotes colorectal cancer metastasis through miR-1322\/CCL20 axis and M2 polarization","volume":"13","author":"Xu","year":"2021","journal-title":"Gut Microbes"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1441785","article-title":"Worldwide research trends in Crohn\u2019s disease treatment over the past 2 decades: a bibliometric analysis","volume":"15","author":"Xu","year":"2024","journal-title":"Front. Pharmacol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1038\/s41591-019-0458-7","article-title":"Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer","volume":"25","author":"Yachida","year":"2019","journal-title":"Nat. Med."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1039882","article-title":"Knowledge atlas of antibody-drug conjugates on CiteSpace and clinical trial visualization analysis","volume":"12","author":"Yao","year":"2022","journal-title":"Front. Oncol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.cell.2017.07.008","article-title":"Fusobacterium nucleatum promotes chemoresistance to colorectal cancer by modulating autophagy","volume":"170","author":"Yu","year":"2017","journal-title":"Cell."},{"key":"B51","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1038\/s41564-024-01784-w","article-title":"The adhesin RadD enhances Fusobacterium nucleatum tumour colonization and colorectal carcinogenesis","volume":"9","author":"Zhang","year":"2024","journal-title":"Nat. Microbiol."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1526406","article-title":"The association between periodontal disease and adverse pregnancy outcomes: a bibliometric analysis from 2000 to 2023","volume":"12","author":"Zhao","year":"2025","journal-title":"Front. Med."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2026.1851307\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:21:57Z","timestamp":1788412917000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2026.1851307\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,3]]},"references-count":52,"alternative-id":["10.3389\/fcimb.2026.1851307"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2026.1851307","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,3]]},"article-number":"1851307"}}