{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:47:29Z","timestamp":1782283649602,"version":"3.54.5"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this single-center, cross-sectional and retrospective study is to assess the prevalence of Chlamydia trachomatis (CT), Mycoplasma genitalium (MG), Neisseria gonorrhoeae (NG), and Ureaplasma urealyticum (UU) among males of the Nanjing Drum Tower Hospital\u2019s Andrology Department in Nanjing, China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In the review, we included male patients who consulted the Nanjing Drum Tower Hospital\u2019s Andrology Department between 2016 and 2025. Urine samples were obtained from the patients, and all samples were tested by nucleic acid amplification tests (NAATs) for CT, MG, NG, and UU.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This research recruited 58,136 males (mean age: 32.29 \u00b1 5.63 years; age range: 16\u201376 years). The positive rates for CT, MG, NG, and UU were 2.62%, 2.77%, 0.85%, and 50.16%, respectively. Males aged \u2264 24 years had the highest positive rates for CT (7.30%), MG (4.76%), and NG (4.89%), whereas males between the ages of 25\u201329 had the highest UU positive rate (53.17%). The single positive rate (93.84%) was significantly more common than mix positive rates (6.16%), alongside the MG+UU mix positive representing the most frequent combination. The \u226424-year age group had significantly more mix-positives than other age groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among males of our andrology outpatient clinic, the incidence of UU positive was markedly greater than that of CT, MG, and NG. Single positives were more predominant. Young people aged \u226424 had higher rates of STIs. Our findings contribute to a better understanding of the epidemiology of CT, MG, NG, and UU in our hospital of Nanjing, which allows for the comparison of patients across various geographies and sources, as well as the analysis of potential causes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1852412","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:55:28Z","timestamp":1782280528000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiology of Chlamydia trachomatis, Mycoplasma genitalium, Neisseria gonorrhoeae, and Ureaplasma urealyticum in males of andrology clinics in Nanjing, China: a 10 years retrospective study"],"prefix":"10.3389","volume":"16","author":[{"given":"Laiqing","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Andrology, Nanjing Drum Tower Hospital","place":["NanJing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Nanjing Integrated Traditional Chinese and Western Medicine Hospital","place":["NanJing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Andrology, Nanjing Drum Tower Hospital","place":["NanJing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Andrology, Nanjing Drum Tower Hospital","place":["NanJing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Andrology, Nanjing Drum Tower Hospital","place":["NanJing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kai","sequence":"additional","affiliation":[{"name":"Department of Andrology, Nanjing Drum Tower Hospital","place":["NanJing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Andrology, Nanjing Drum Tower Hospital","place":["NanJing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"B25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12916-021-02160-9","article-title":"Diagnostic accuracy of pooling urine, anorectal, and oropharyngeal specimens for the detection of chlamydia trachomatis and neisseria gonorrhoeae: a systematic review and meta-analysis","volume":"19","author":"Aboud","year":"2021","journal-title":"BMC Med."},{"key":"B1","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1136\/sextrans-2017-053384","article-title":"Prevalence of mycoplasma genitalium in different population groups: systematic review andmeta-analysis","volume":"94","author":"Baumann","year":"2018","journal-title":"Sex Transm. 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