{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:16:56Z","timestamp":1788239816465,"version":"build-2803163510"},"reference-count":145,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Graves\u2019 disease (GD) is an autoimmune form of hyperthyroidism characterized by loss of immune tolerance to the thyrotropin receptor and sustained thyroid hormone excess. Interest in the gut\u2013thyroid axis has expanded rapidly, placing the gut microbiota within current models of GD pathophysiology. This review summarizes current evidence on gut microbial alterations in GD and discusses how these changes may intersect with thyroid autoimmunity. Available studies broadly support disruption of the intestinal microbial ecosystem in GD, although findings for individual taxa and diversity indices vary across cohorts. Proposed links between dysbiosis and disease include altered short-chain fatty acid and bile acid metabolism, impairment of epithelial barrier integrity with translocation of microbial products, shifts in Th17\/Treg balance and related immune activation, molecular mimicry, and disturbed handling of micronutrients involved in thyroid hormone synthesis and metabolism. The oral\u2013gut microbial connection has also emerged as a potentially relevant dimension of disease-associated dysbiosis. In parallel, microbiota-directed approaches, including probiotics, prebiotics, synbiotics, dietary modulation, and fecal microbiota transplantation, are being explored as possible adjuncts in GD management. Overall, gut microbial disturbance offers a biologically plausible link between environmental exposure, immune disequilibrium, and thyroid dysfunction in GD; however, stronger mechanistic, longitudinal, and interventional evidence is still required before these findings can be translated into precision clinical practice.<\/jats:p>","DOI":"10.3389\/fcimb.2026.1859658","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:26:43Z","timestamp":1788236803000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The gut microbiota in Graves\u2019 disease: mechanistic insights and clinical implications"],"prefix":"10.3389","volume":"16","author":[{"given":"Leyang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boxian","family":"Pang","sequence":"additional","affiliation":[{"name":"Third Affiliated Hospital of Beijing University of Chinese Medicine","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junping","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s00018-018-2943-4","article-title":"An insight into gut microbiota and its functionalities","volume":"76","author":"Adak","year":"2019","journal-title":"Cell. 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