{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:55:13Z","timestamp":1781502913323,"version":"3.54.1"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515011424, 2025A1515012352"],"award-info":[{"award-number":["2024A1515011424, 2025A1515012352"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"\n Objective<\/jats:title>\n Pus culture and antimicrobial susceptibility testing play an important role in pathogen identification and the adjustment of empirical therapy for localized suppurative infections. This study aimed to investigate the distribution of major bacterial pathogens isolated from pus cultures and their susceptibility profiles to commonly used antimicrobial agents among hospitalized patients at Longgang District Maternity &amp; Child Healthcare Hospital of Shenzhen City, in order to provide evidence for rational clinical antimicrobial use.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We retrospectively collected pus culture records and aggregated antimicrobial susceptibility data from January 1, 2021 to December 31, 2025.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n From 2021 to 2025, 586 non-duplicate bacterial isolates were recovered from positive pus cultures, of which 64.7% were Gram-negative and 35.3% were Gram-positive. The leading isolates were\n Escherichia coli<\/jats:italic>\n (48.0%) and\n Staphylococcus aureus<\/jats:italic>\n (22.5%), followed by\n Klebsiella pneumoniae subsp. pneumoniae<\/jats:italic>\n (7.0%),\n Staphylococcus epidermidis<\/jats:italic>\n (3.8%), Pseudomonas aeruginosa (2.4%), and\n Streptococcus agalactiae<\/jats:italic>\n (1.4%). Positive cultures were mainly from the Departments of Pediatric Surgery, General Surgery, Gynecology, and Breast Surgery, with a bimodal age distribution peaking in young children and women of reproductive age; among Pediatric Surgery cases, males predominated, especially in the 0-3-year group. Extended-spectrum beta-lactamase production was detected in 28.1% of\n Escherichia coli<\/jats:italic>\n and 20.0% of\n Klebsiella pneumoniae subsp. pneumoniae<\/jats:italic>\n isolates.\n Escherichia coli<\/jats:italic>\n showed high resistance to ampicillin, trimethoprim-sulfamethoxazole, and ciprofloxacin but remained highly susceptible to imipenem and amikacin.\n Klebsiella pneumoniae subsp. pneumoniae<\/jats:italic>\n remained highly susceptible to amikacin, cefoxitin, and ertapenem despite resistance to several cephalosporins and ciprofloxacin. A subset of\n Staphylococcus aureus<\/jats:italic>\n isolates was methicillin resistant, with frequent resistance to erythromycin and clindamycin, whereas vancomycin and linezolid retained good\n in vitro<\/jats:italic>\n activity.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Empirical antimicrobial therapy for localized suppurative infections in this maternal and child healthcare specialty hospital should be guided by local pathogen distribution and antimicrobial susceptibility surveillance, with coverage for both Enterobacterales and staphylococci.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1860912","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:34:18Z","timestamp":1781501658000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Bacterial pathogen spectrum and antimicrobial resistance in positive pus cultures from hospitalized patients at a maternal and child healthcare specialty hospital in Shenzhen, China, 2021\u20132025"],"prefix":"10.3389","volume":"16","author":[{"given":"Tongyan","family":"Ding","sequence":"first","affiliation":[{"name":"Clinical Laboratory, Key Laboratory of Bacterial Antimicrobial Resistance and Prevention, Medical Research Institute of Maternal and Child, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City (Affiliated Shenzhen Women and Children\u2019s Hospital (Longgang) of Shantou University Medical College)","place":["Shenzhen, Guangdong, China"]},{"name":"Clinical Laboratory, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Laboratory Medicine","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Key Laboratory of Bacterial Antimicrobial Resistance 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