{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:52:25Z","timestamp":1791568345335,"version":"4.3.4"},"reference-count":80,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    <jats:italic>Candida auris<\/jats:italic>\n                    , designated a critical-priority fungal pathogen by the World Health Organization, poses a growing threat to healthcare systems worldwide. Analysis of 80 peer-reviewed studies reveals five principal findings: (1)\n                    <jats:italic>C. auris<\/jats:italic>\n                    exhibits clade-dependent geographic distribution and resistance profiles\u2014Clade I (South Asia) and Clade III show fluconazole resistance exceeding 90%, whereas Clade IV exhibits 44% resistance; echinocandin resistance varies significantly by clade and no resistance was detected in certain clades; amphotericin B resistance varies from no detected resistance to 46% depending on clade; and pan-resistant strains have emerged; (2) biofilm-associated\n                    <jats:italic>C. auris<\/jats:italic>\n                    cells (sessile cells) exhibit MBECs 2- to 4,119-fold higher than planktonic MICs, representing a major driver of persistent colonization; (3) novel antifungal agents, including ibrexafungerp, manogepix (the active moiety of fosmanogepix), and rezafungin, demonstrate promising\n                    <jats:italic>in vitro<\/jats:italic>\n                    activity against\n                    <jats:italic>C. auris<\/jats:italic>\n                    , with manogepix showing the highest overall antibiofilm activity (geometric mean MBEC of 5.9 \u03bcg\/mL) and ibrexafungerp demonstrating superior activity against Clade IV biofilms; (4) a tiered infection prevention and control (IPC) framework\u2014integrating universal screening, contact precautions, and environmental decontamination\u2014has been associated with reduced transmission rates in outbreak settings; and (5) climate change and global warming may have contributed to the emergence of\n                    <jats:italic>C. auris<\/jats:italic>\n                    through thermal adaptation of environmental fungal species. These findings indicate that effective mitigation of the\n                    <jats:italic>C. auris<\/jats:italic>\n                    threat requires integrated surveillance, susceptibility-guided therapy accounting for both planktonic and biofilm activity, and resilient healthcare systems adapted to the clade-specific epidemiology of this pathogen.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2026.1873741","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T04:24:05Z","timestamp":1783657445000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Candida auris: a review of global epidemiology, multidrug resistance, and infection control in healthcare-associated outbreaks"],"prefix":"10.3389","volume":"16","author":[{"given":"Xuewei","family":"Du","sequence":"first","affiliation":[{"name":"Department of Public Health, Affiliated Hospital of Inner Mongolia Medical University","place":["Hohhot, Inner Mongolia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Public Health, Affiliated Hospital of Inner Mongolia Medical University","place":["Hohhot, Inner Mongolia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"179","DOI":"10.7883\/yoken.jjid.2025.025","article-title":"Microbiological characteristics and drug resistance rates of Candida auris isolates in Japan","volume":"78","author":"Abe","year":"2025","journal-title":"Jpn. 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