{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:05:55Z","timestamp":1784264755647,"version":"3.55.0"},"reference-count":165,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    remains a significant challenge to human medicine as it causes acute and chronic infections at several locations in the body, including the lung and eyes.\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    is a very versatile, highly adaptable, opportunistic pathogen due to its large genome, ability to form protective biofilms and metabolic adaptation. Targeted, susceptibility-guided antibiotic therapy represents the best clinical approach to treat\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    infections. However, due to the emergence of antibiotic resistance and the lack of a vaccine, it is critical to accelerate the development of novel, antipseudomonal therapies. Hypothiocyanous acid (HOSCN) occurs naturally in the human body and serves as an antimicrobial reactive oxidant in mucosal secretions, including the airway surface liquid, saliva, tears and milk. Mucosal peroxidase enzymes generate HOSCN from its substrates, thiocyanate (SCN\n                    <jats:sup>-<\/jats:sup>\n                    ) and H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    . HOSCN has been reported to kill\n                    <jats:italic>P. aeruginosa in vitro<\/jats:italic>\n                    which indicates its potential to be used as a new mechanism to target this bacterium. This review article provides a brief overview of the human clinical relevance of\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    and summarizes current knowledge on the\n                    <jats:italic>in vitro<\/jats:italic>\n                    antibacterial efficacy and mechanism of action of HOSCN against this pathogen. This work also reviews the mechanisms by which\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    attempts to adapt to the antibacterial actions of HOSCN.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2026.1878666","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T04:23:38Z","timestamp":1784262218000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Factors governing the response of Pseudomonas aeruginosa to hypothiocyanous acid"],"prefix":"10.3389","volume":"16","author":[{"given":"Chelsey M.","family":"VanDrisse","sequence":"first","affiliation":[{"name":"Department of Genetics, Franklin College of Arts and Sciences, The University of Georgia","place":["Athens, GA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Swenson","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine","place":["Atlanta, GA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin M.","family":"Hudock","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Cincinnati College of Medicine","place":["Cincinnati, OH, United States"]},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine","place":["Cincinnati, OH, United States"]},{"name":"Division of Pulmonary Biology, Cincinnati Children\u2019s Hospital Medical Center","place":["Cincinnati, OH, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene A.","family":"Stecenko","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Asthma, Cystic Fibrosis and Sleep, Department of Pediatrics, Emory University School of Medicine","place":["Atlanta, GA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"Rada","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, College of Veterinary Medicine, The University of Georgia","place":["Athens, GA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"B1","volume-title":"Cystic Fibrosis Foundation Patient Registry 2024 Annual Data Report","year":"2024"},{"key":"B2","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1021\/tx200219s","article-title":"Hypothiocyanous acid: benign or deadly","volume":"25","author":"Barrett","year":"2012","journal-title":"Chem. 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