{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:02:01Z","timestamp":1784869321686,"version":"3.55.0"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"\n Background<\/jats:title>\n The research on pancreatitis and gut microbiota has expanded rapidly in recent years. Growing evidence suggests that gut dysbiosis may play an important role in pancreatic inflammation, intestinal barrier dysfunction and disease progression, but global research landscape, major contributors, knowledge structure and hotspots have not been fully defined.<\/jats:p>\n <\/jats:sec>\n \n Materials and methods<\/jats:title>\n Publications related to pancreatitis and gut microbiota were retrieved from the Web of Science Core Collection and Scopus. The search was conducted on Jan 5, 2026, and covered studies published between 2006 and 2025. Bibliometrix, VOSviewer, CiteSpace and Microsoft Excel were used to analyze the annual publication trends, journal sources, authors, countries, institutions, cited articles, co-cited references, keyword co-occurrence, thematic clustering, and time evolution.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The annual number of publications increased markedly from 2006 to 2025, with sustained acceleration after 2020. Pre- and post-2020 comparison suggested a shift from early clinical and intervention-oriented topics toward more mechanism-based and translational research, including gut microbiota, immune regulation, and multi-omics approaches. China contributed the most publications, followed by the United States. Citation and co-citation analyses identified major thematic groups related to acute pancreatitis, chronic pancreatitis, pancreatic homeostasis, dietary intervention, and microbiota-targeted research. Frequent keywords included human, gut microbiota, acute pancreatitis, intestinal flora, inflammation, dysbiosis, probiotics and chronic pancreatitis. Recent burst keywords were more closely related to bifidobacterium, short-chain fatty acids, metabolomics, acute lung injury, fecal analysis, and lipopolysaccharide, suggesting changing research attention toward mechanism-oriented and translational topics.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This bibliometric analysis provides a detailed overview of global studies on pancreatitis and gut microbiota from 2006 to 2025. The field has expanded rapidly, and bibliometric patterns suggest increasing attention to mechanistic and translational investigations. Some highly co-cited references were related to pancreatic cancer, inflammatory bowel disease, microbial metabolites, immune regulation, and host-microbe interactions rather than pancreatitis itself, reflecting the broader knowledge base of this research field. Acute pancreatitis remained the most studied topic, while chronic pancreatitis, microbial metabolites, host response, and microbiota-targeted approaches gained increasing attention in recent years. Future research may shift from descriptive microbiota profiling to mechanism-oriented and translational studies.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1878923","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:22:45Z","timestamp":1784866965000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Global landscape and knowledge structure of research on pancreatitis and gut microbiota: a bibliometric analysis based on WoSCC and Scopus (2006 - 2025)"],"prefix":"10.3389","volume":"16","author":[{"given":"Huichuan","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Emergency, Xi\u2019an Hospital of Traditional Chinese Medicine","place":["Xi\u2019an, China"]},{"name":"Faculty of Chinese Medicine, Macau University of Science and Technology","place":["Taipa, Macao SAR, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangyue","family":"Wang","sequence":"additional","affiliation":[{"name":"Faculty of Chinese Medicine, Macau University of Science and Technology","place":["Taipa, Macao SAR, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"He","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Hubei University of Medicine","place":["Shiyan, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanlu","family":"Li","sequence":"additional","affiliation":[{"name":"Faculty of Chinese Medicine, Macau University of Science and Technology","place":["Taipa, Macao SAR, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Emergency, Xi\u2019an Hospital of Traditional Chinese Medicine","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Emergency, Xi\u2019an Hospital of Traditional Chinese Medicine","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"B41","volume-title":"Hepato-gastroenterology","year":"2007"},{"key":"B16","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.pan.2022.11.011","article-title":"Acute pancreatitis is characterized by generalized intestinal barrier dysfunction in early stage","volume":"23","author":"Agarwal","year":"2023","journal-title":"Pancreatology"},{"key":"B43","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.cmet.2017.02.007","article-title":"Orai1-mediated antimicrobial secretion from pancreatic acini shapes the gut microbiome and regulates gut innate immunity","volume":"25","author":"Ahuja","year":"2017","journal-title":"Cell Metab."},{"key":"B20","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1136\/gutjnl-2023-330987","article-title":"Gut microbiota predicts severity and reveals novel metabolic signatures in acute pancreatitis","volume":"73","author":"Ammer-Herrmenau","year":"2024","journal-title":"Gut"},{"key":"B23","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.joi.2017.08.007","article-title":"bibliometrix: an R-tool for comprehensive science mapping analysis","volume":"11","author":"Aria","year":"2017","journal-title":"J. Informetr."},{"key":"B28","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/s41586-019-1608-2","article-title":"The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL","volume":"574","author":"Aykut","year":"2019","journal-title":"Nature"},{"key":"B4","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1136\/gutjnl-2012-302779","article-title":"Classification of acute pancreatitis\u20142012: revision of the Atlanta classification and definitions by international consensus","volume":"62","author":"Banks","year":"2013","journal-title":"Gut"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1016\/S0140-6736(07)60751-X","article-title":"Inflammatory bowel disease: clinical aspects and established and evolving therapies","volume":"369","author":"Baumgart","year":"2007","journal-title":"Lancet"},{"key":"B52","unstructured":"Severe acute pancreatitis: Clinical course and management\n \n \n \n Beger\n H. G.\n \n \n Rau\n B. M.\n \n \n \n 2007"},{"key":"B18","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/S0140-6736(08)60207-X","article-title":"Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial","volume":"371","author":"Besselink","year":"2008","journal-title":"Lancet"},{"key":"B17","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nbt.3436","article-title":"A reassessment of the PROPATRIA study and its implications for probiotic therapy","volume":"34","author":"Bongaerts","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3390\/nu17172720","article-title":"Nutritional management in chronic pancreatitis: from exocrine pancreatic insufficiency to precision therapy","volume":"17","author":"Bruni","year":"2025","journal-title":"Nutrients"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf9794","article-title":"Kynurenines: tryptophan\u2019s metabolites in exercise, inflammation, and mental health","volume":"357","author":"Cervenka","year":"2017","journal-title":"Science"},{"key":"B22","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/asi.20317","article-title":"CiteSpace II: detecting and visualizing emerging trends and transient patterns in scientific literature","volume":"57","author":"Chen","year":"2006","journal-title":"J. Am. Soc Inf. Sci. Technol."},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176583","article-title":"Dysbiosis of intestinal microbiota and decrease in paneth cell antimicrobial peptide level during acute necrotizing pancreatitis in rats","volume":"12","author":"Chen","year":"2017","journal-title":"PLoS ONE"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1503087","article-title":"Mitochondrial dysfunction in pancreatic acinar cells: mechanisms and therapeutic strategies in acute pancreatitis","volume":"15","author":"Chen","year":"2024","journal-title":"Front. Immunol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1136\/gutjnl-2011-300784","article-title":"Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer","volume":"61","author":"Farrell","year":"2012","journal-title":"Gut"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2566","DOI":"10.1056\/NEJMra1607547","article-title":"Irritable bowel syndrome","volume":"376","author":"Ford","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1053\/j.gastro.2018.10.047","article-title":"Impaired exocrine pancreatic function associates with changes in intestinal microbiota composition and diversity","volume":"156","author":"Frost","year":"2019","journal-title":"Gastroenterology"},{"key":"B56","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1136\/gutjnl-2020-322753","article-title":"Long-term instability of the intestinal microbiome is associated with metabolic liver disease, low microbiota diversity, diabetes mellitus and impaired exocrine pancreatic function","volume":"70","author":"Frost","year":"2021","journal-title":"Gut"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000232","article-title":"The gut microbiome in patients with chronic pancreatitis is characterized by significant dysbiosis and overgrowth by opportunistic pathogens","volume":"11","author":"Frost","year":"2020","journal-title":"Clin. Transl. Gastroenterol."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.01507-21","article-title":"Paneth cells protect against acute pancreatitis via modulating gut microbiota dysbiosis","volume":"7","author":"Fu","year":"2022","journal-title":"mSystems"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.658354","article-title":"Impact of bacterial metabolites on gut barrier function and host immunity: a focus on bacterial metabolism and its relevance for intestinal inflammation","volume":"12","author":"Gasaly","year":"2021","journal-title":"Front. Immunol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1136\/gutjnl-2022-327448","article-title":"Activated regulatory T-cells promote duodenal bacterial translocation into necrotic areas in severe acute pancreatitis","volume":"72","author":"Glaubitz","year":"2023"},{"key":"B10","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1097\/MPA.0000000000001298","article-title":"Recent insights into the pathogenic mechanism of pancreatitis: role of acinar cell organelle disorders","volume":"48","author":"Gukovskaya","year":"2019","journal-title":"Pancreas"},{"key":"B31","doi-asserted-by":"publisher","first-page":"4298","DOI":"10.3748\/wjg.v27.i27.4298","article-title":"Pancreatic cancer: a review of epidemiology, trend, and risk factors","volume":"27","author":"Hu","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/s41574-019-0254-y","article-title":"The heterogeneous pathogenesis of type 1 diabetes mellitus","volume":"15","author":"Ilonen","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/srep43640","article-title":"Altered intestinal microbiota in patients with chronic pancreatitis: implications in diabetes and metabolic abnormalities","volume":"7","author":"Jandhyala","year":"2017","journal-title":"Sci. Rep."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1007\/s40265-020-01360-6","article-title":"Chronic pancreatitis: Epidemiology, diagnosis, and management updates","volume":"80","author":"Kichler","year":"2020","journal-title":"Drugs"},{"key":"B54","doi-asserted-by":"publisher","first-page":"17060","DOI":"10.1038\/nrdp.2017.60","article-title":"Chronic pancreatitis","volume":"3","author":"Kleeff","year":"2017","journal-title":"Nat. Rev. Dis. Primer"},{"key":"B27","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41575-021-00457-x","article-title":"Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors","volume":"18","author":"Klein","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1089\/sur.2015.034","article-title":"Severe acute pancreatitis: gut barrier failure, systemic inflammatory response, acute lung injury, and the role of the mesenteric lymph","volume":"16","author":"Landahl","year":"2015","journal-title":"Surg. Infect."},{"key":"B5","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/s41575-019-0158-2","article-title":"New insights into acute pancreatitis","volume":"16","author":"Lee","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.3748\/wjg.v26.i18.2187","article-title":"Role of gut microbiota on intestinal barrier function in acute pancreatitis","volume":"26","author":"Li","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e23483","article-title":"Bibliometric analysis of pancreatic diseases and gut microbiota research from 2002 to 2022","volume":"10","author":"Li","year":"2024","journal-title":"Heliyon"},{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0327831","article-title":"The global, regional and national burden of pancreatitis due to alcohol use: results from the Global Burden of Disease Study 2021 and projections to 2040","volume":"20","author":"Li","year":"2025"},{"key":"B14","unstructured":"Updated review of research on the role of the gut microbiota and microbiota-derived metabolites in acute pancreatitis progression and inflammation-targeted therapy\n \n \n \n Liu\n Q.\n \n \n Ruan\n K.\n \n \n An\n Z."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1126\/science.1233521","article-title":"Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity","volume":"339","author":"Markle","year":"2013","journal-title":"Science"},{"key":"B53","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1001\/jama.2020.20317","article-title":"Acute pancreatitis: A review","volume":"325","author":"Mederos","year":"2021","journal-title":"JAMA"},{"key":"B37","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3967\/bes2018.010","article-title":"Intestinal microbial community differs between acute pancreatitis patients and healthy volunteers","volume":"31","author":"Mei","year":"2018","journal-title":"Biomed. Environ. Sci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1097\/MPA.0000000000001137","article-title":"Exocrine pancreatic insufficiency and malnutrition in chronic pancreatitis: identification, treatment, and consequences","volume":"47","author":"Min","year":"2018","journal-title":"Pancreas"},{"key":"B40","first-page":"590","article-title":"Synbiotic control of inflammation and infection in severe acute pancreatitis: a prospective, randomized, double blind study","volume":"54","author":"Ol\u00e1h","year":"2007","journal-title":"Hepato-gastroenterology"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nut.2017.06.019","article-title":"The prevalence of underweight is increased in chronic pancreatitis outpatients and associates with reduced life quality","author":"Olesen","year":"2017","journal-title":"Nutrition"},{"key":"B49","doi-asserted-by":"publisher","first-page":"4446","DOI":"10.1111\/bph.14806","article-title":"Butyrate ameliorates caerulein-induced acute pancreatitis and associated intestinal injury by tissue-specific mechanisms","volume":"176","author":"Pan","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/s41575-018-0087-5","article-title":"Global epidemiology and holistic prevention of pancreatitis","volume":"16","author":"Petrov","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1158\/2159-8290.CD-17-1134","article-title":"The pancreatic cancer microbiome promotes oncogenesis by induction of innate and adaptive immune suppression","volume":"8","author":"Pushalkar","year":"2018","journal-title":"Cancer Discov."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1053\/j.gastro.2019.01.268","article-title":"Early intra-acinar events in pathogenesis of pancreatitis","volume":"156","author":"Saluja","year":"2019","journal-title":"Gastroenterology"},{"key":"B42","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1177\/0148607107031002119","article-title":"Synbiotics, prebiotics, glutamine, or peptide in early enteral nutrition: a randomized study in trauma patients","volume":"31","author":"Spindler-Vesel","year":"2007","journal-title":"J. Parenter Enter Nutr."},{"key":"B34","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1097\/MPA.0000000000000355","article-title":"Dysbiosis of intestinal microbiota associated with inflammation involved in the progression of acute pancreatitis","volume":"44","author":"Tan","year":"2015","journal-title":"Pancreas"},{"key":"B38","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41575-019-0242-7","article-title":"Microbiota in pancreatic health and disease: the next frontier in microbiome research","volume":"17","author":"Thomas","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1136\/gutjnl-2019-320430","article-title":"Western-type diet influences mortality from necrotising pancreatitis and demonstrates a central role for butyrate","volume":"70","author":"van den Berg","year":"2021","journal-title":"Gut"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1572346","article-title":"Global burden of pancreatitis among individuals aged 15\u201339 years: a systematic analysis from the 2021 GBD study","volume":"12","author":"Xu","year":"2025","journal-title":"Front. Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1038\/mi.2017.118","article-title":"GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3","volume":"11","author":"Zhao","year":"2018","journal-title":"Mucosal Immunol."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00059-19","article-title":"Commensal Escherichia coli aggravates acute necrotizing pancreatitis through targeting of intestinal epithelial cells","volume":"85","author":"Zheng","year":"2019","journal-title":"Appl. Environ. Microbiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s00535-018-1529-0","article-title":"Gut microbiota dysbiosis worsens the severity of acute pancreatitis in patients and mice","volume":"54","author":"Zhu","year":"2018","journal-title":"J. Gastroenterol."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111850","article-title":"Alteration of gut microbiota in acute pancreatitis and associated therapeutic strategies","volume":"141","author":"Zhu","year":"2021","journal-title":"Biomed. Pharmacother."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2026.1878923\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:22:48Z","timestamp":1784866968000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2026.1878923\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,24]]},"references-count":56,"alternative-id":["10.3389\/fcimb.2026.1878923"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2026.1878923","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,24]]},"article-number":"1878923"}}