{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:18:52Z","timestamp":1786115932464,"version":"build-2736575974"},"reference-count":68,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012497","name":"Covenant University Centre for Research, Innovation and Discovery","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Population-level studies have linked malaria endemicity to shorter leukocyte telomere length, but the patient-level molecular basis of this association remains unknown. This study investigated the associations of microscopy-confirmed malaria with relative leukocyte telomere length (rTL), human telomerase reverse transcriptase (hTERT) expression, parasite density, and haematological parameters in an endemic Nigerian cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 304 participants with complete microscopy and haematological data were included, comprising equal numbers of malaria-positive (n = 152) and malaria-negative (n = 152) individuals. From this cohort, an age-matched molecular subset of 40 participants (22 malaria-positive and 18 malaria-negative) was selected for rTL and hTERT analyses. Relative leukocyte telomere length was determined as the telomere-to-single-copy gene (T\/S) ratio using 36B4, while hTERT expression was quantified by RT-qPCR using GAPDH as the housekeeping gene.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Malaria-positive participants had significantly lower haemoglobin and platelet counts than controls (both\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001). In the molecular subset, malaria-positive participants had significantly shorter rTL than controls (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001), whereas hTERT expression was significantly higher (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004). Among malaria-positive participants, rTL differed across parasite-density categories (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.011) and was inversely associated with parasite density (r = \u22120.68,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001). Exploratory multivariable analyses showed that malaria positivity and higher parasite density were independently associated with shorter relative leukocyte telomere length.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion\/conclusion<\/jats:title>\n                    <jats:p>To the best of our knowledge, this study is the first to provide patient-level evidence supporting the hypothesis that active malaria may contribute to the shorter relative leukocyte telomere length observed in malaria-endemic African populations. Longitudinal studies are needed to determine whether these changes are transient, cumulative, or reversible following treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1880313","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T06:25:00Z","timestamp":1785997500000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Naturally acquired malaria is associated with shorter leukocyte relative telomere length and increased hTERT expression in an endemic nigerian population"],"prefix":"10.3389","volume":"16","author":[{"given":"Theophilus Nang","family":"Wakai","sequence":"first","affiliation":[{"name":"Covenant Applied Informatics and Communication\u2013Africa Centre of Excellence (CApIC-ACE)","place":["Ota, Nigeria"]},{"name":"Department of Biochemistry, College of Science and Technology, Covenant University","place":["Ota, Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalom Nwodo","family":"Chinedu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Science and Technology, Covenant University","place":["Ota, Nigeria"]},{"name":"Covenant University Public Health and Wellbeing Research Cluster (CUPHWERC), Covenant University","place":["Ota, Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel Sunmola","family":"Afolabi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Science and Technology, Covenant University","place":["Ota, Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12936-025-05296-8","article-title":"Prevalence of thrombocytopenia among patients with malaria in Ethiopia: a systematic review and meta-analysis","volume":"24","author":"Achame","year":"2025","journal-title":"Malar. 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