{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:07:02Z","timestamp":1789020422297,"version":"build-2803163510"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      (\n                      <jats:italic>H. pylori<\/jats:italic>\n                      ) infection is strongly linked to multiple diseases. Inflammation and nutritional status are intricately intertwined with\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection; however, most prior studies failed to integrate these two dimensions in a unified assessment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study enrolled 3,718 eligible participants from the 1999\u20132000 National Health and Nutrition Examination Survey (NHANES). Multivariate logistic regression was utilized to examine the association between the ALI and\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection. Cox proportional hazards regression was employed to evaluate the association between ALI and all-cause mortality in\n                      <jats:italic>H. pylori<\/jats:italic>\n                      -infected patients. Restricted cubic splines (RCS) were implemented to characterize potential nonlinear relationships. Subgroup analysis explores the consistency of the associations among different populations. An independent duplicate cohort from the Second Affiliated Hospital of Nanchang University was additionally incorporated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Elevated ALI emerged as a relevant factor for\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection. Higher ALI levels were associated with improved survival prognosis. Beyond an inflection point (log2ALI=5.44) this negative association gradually diminished. Subgroup analyses revealed that the interaction test showed that no significant interaction was found for all stratification factors. The association between ALI and\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection was consistent among the above subgroups. Independent duplicate cohort corroborated that as the level of log\n                      <jats:sub>2<\/jats:sub>\n                      ALI increases, the likelihood of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection showed a monotonous increasing trend.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Higher ALI levels were positively associated with an increased risk of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection, and this association was consistent in an independent duplicate cohort. Among\n                      <jats:italic>H. pylori<\/jats:italic>\n                      -infected individuals, higher ALI was related to reduced all-cause mortality, with the association most prominent at lower ALI ranges.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1881537","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:33:26Z","timestamp":1789018406000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The association of the advanced lung cancer inflammation index with the risk of Helicobacter pylori infection and mortality: a study of populations from two countries"],"prefix":"10.3389","volume":"16","author":[{"given":"Qibo","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Nanchang University","place":["Nanchang, Jiangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huangxin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University","place":["Nanchang, Jiangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit, The First Affiliated Hospital of Xiamen University","place":["Xiamen, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Nanchang University","place":["Nanchang, Jiangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Nanchang University","place":["Nanchang, Jiangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen\u2019an","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Nanchang University","place":["Nanchang, Jiangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"116","DOI":"10.23736\/S1121-421X.19.02568-6","article-title":"Helicobacter pylori and nutrition: a bidirectional communication","volume":"65","author":"Aimasso","year":"2019","journal-title":"Minerva gastroenterologica e dietologica"},{"key":"B2","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1038\/s41591-023-02232-8","article-title":"Body composition and lung cancer-associated cachexia in TRACERx","volume":"29","author":"Al-Sawaf","year":"2023","journal-title":"Nat. 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