{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:28:11Z","timestamp":1786512491070,"version":"build-2736575974"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    is a major gastric pathogen associated with chronic gastritis, peptic ulcers, and gastric cancer, while increasing antibiotic resistance has reduced the effectiveness of standard eradication therapies. This study investigated the antibacterial, antibiofilm, anti-inflammatory, probiotic-related, and genomic properties of cell-free supernatant (LCFS) derived from\n                    <jats:italic>Lactiplantibacillus pentosus<\/jats:italic>\n                    CROT01 against\n                    <jats:italic>H. pylori<\/jats:italic>\n                    . LCFS exhibited inhibitory activity against all tested\n                    <jats:italic>H. pylori<\/jats:italic>\n                    strains, including the clarithromycin-resistant strain ATCC 700684, with inhibition zones ranging from 10.67 \u00b1 0.58 to 17.33 \u00b1 1.53\u00a0mm. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) ranged from 12.5\u201350 mg\/mL and 25\u201350 mg\/mL, respectively. LCFS significantly inhibited biofilm formation and eradicated established\n                    <jats:italic>H. pylori<\/jats:italic>\n                    biofilms. Scanning electron microscopy revealed marked morphological alterations in treated cells, including membrane disruption, deformation, and cellular shrinkage. Anti-inflammatory activity was demonstrated through suppression of nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells. In addition,\n                    <jats:italic>L. pentosus<\/jats:italic>\n                    CROT01 exhibited tolerance to acidic pH and pancreatin, high cell surface hydrophobicity, and moderate adhesion ability toward Caco-2 cells. Whole-genome sequencing identified several bacteriocin-associated genes, including\n                    <jats:italic>plantaricin E<\/jats:italic>\n                    ,\n                    <jats:italic>plantaricin F<\/jats:italic>\n                    ,\n                    <jats:italic>pediocin, enterolysin A<\/jats:italic>\n                    , and\n                    <jats:italic>bovicin-related peptides<\/jats:italic>\n                    , whereas no virulence-associated or acquired antimicrobial resistance genes were detected. Thus, these findings suggest that LCFS derived from\n                    <jats:italic>L. pentosus<\/jats:italic>\n                    CROT01 possesses promising anti-\n                    <jats:italic>H. pylori<\/jats:italic>\n                    activity and may represent a potential postbiotic-based strategy against antibiotic-resistant\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2026.1882551","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T04:42:39Z","timestamp":1786509759000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Genomic characterization and biological activities of cell-free supernatant from Lactiplantibacillus pentosus CROT01 against clarithromycin-resistant Helicobacter pylori"],"prefix":"10.3389","volume":"16","author":[{"given":"Chonticha","family":"Romyasamit","sequence":"first","affiliation":[{"name":"Department of Medical Technology, School of Allied Health Sciences, Walailak University","place":["Nakhon Si Thammarat, Thailand"]},{"name":"Research Center for Microbiome, Systems Biology, and Medical Innovation, Walailak University","place":["Nakhon Si Thammarat, Thailand"]},{"name":"Research Center in Tropical Pathobiology, Walailak University","place":["Nakhon Si Thammarat, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Saki","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences","place":["Ahvaz, Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phanvasri","family":"Saengsuwan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University","place":["Songkhla, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuvamin","family":"Suriyaamporn","sequence":"additional","affiliation":[{"name":"Research and Innovation Center for Advanced Therapy Medicinal Products, Division of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University","place":["Nakhon Pathom, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teeratas","family":"Kansom","sequence":"additional","affiliation":[{"name":"Research and Innovation Center for Advanced Therapy Medicinal Products, Division of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University","place":["Nakhon Pathom, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theerachai","family":"Thammathiwat","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Faculty of Medicine, Naresuan University","place":["Phitsanulok, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuttapon","family":"Sadaeng","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, Faculty of Dentistry, Naresuan University","place":["Phitsanulok, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisa","family":"Thiamsakul","sequence":"additional","affiliation":[{"name":"Institute of Marine Science, Burapha University","place":["Chonburi, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natthapong","family":"Sueviriyapan","sequence":"additional","affiliation":[{"name":"The Petroleum and Petrochemical College, Chulalongkorn University","place":["Bangkok, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kitbordin","family":"Thongduang","sequence":"additional","affiliation":[{"name":"Faculty of Public Health, Naresuan University","place":["Phitsanulok, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kannaphak","family":"Tantasith","sequence":"additional","affiliation":[{"name":"Faculty of Law, Naresuan University","place":["Phitsanulok, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raksiri","family":"Kaewtawee","sequence":"additional","affiliation":[{"name":"School of Architecture and Design, Walailak University","place":["Nakhon Si Thammarat, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoomjai","family":"Sornsenee","sequence":"additional","affiliation":[{"name":"Department of Family and Preventive Medicine, Faculty of Medicine, Prince of Songkla University","place":["Songkhla, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/s40001-025-03725-7","article-title":"Current concepts of Helicobacter pylori infection","volume":"31","author":"Akinpelu","year":"2025","journal-title":"Eur. 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