{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:30:43Z","timestamp":1786681843606,"version":"build-2736575974"},"reference-count":59,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the epidemiological characteristics of CRKP responsible for BSIs in Hebei Province, China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 100 CRKP isolates were obtained across 15 hospitals in eight cities in Hebei Province, China, between 2022 and 2024. Polymerase chain reaction and short-read whole-genome sequencing were used to characterize the molecular profiles of the strains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All isolates exhibited high-level resistance to \u03b2-lactam antibiotics, including a 100% resistance rate to carbapenems and resistance rates of &amp;gt; 97% to \u03b2-lactamase inhibitor combinations. The\n                      <jats:italic>blaKPC<\/jats:italic>\n                      was the predominant carbapenemase gene (89%, 89\/100). In this study, 62 carbapenem-resistant\n                      <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                      isolates harboring multiple hypervirulence-related genes (CR-hvKp) and 38 carbapenem-resistant classical\n                      <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                      (CR-cKp) isolates were identified. The predominant plasmid replicon types were IncFII(pHN7A8) (69%, 69\/100) and ColRNAI (71%, 71\/100). Notably, according to the core-genome SNP analysis, the ST11-KL64 subclone was the predominant lineage among the sampled isolates (48%, 48\/100).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The CRKP isolates from BSIs exhibit significant drug resistance and high virulence characteristics, warranting widespread clinical attention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1883044","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:22:43Z","timestamp":1786681363000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Regional surveillance of carbapenem-resistant Klebsiella pneumoniae responsible for bloodstream infections in Hebei province"],"prefix":"10.3389","volume":"16","author":[{"given":"Yuyao","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, The Affiliated Hospital of Chengde Medical University","place":["Chengde, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Chengde Medical University","place":["Chengde, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Affiliated Hospital of Chengde Medical University","place":["Chengde, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoujun","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Affiliated Hospital of Chengde Medical University","place":["Chengde, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Hebei Key Laboratory of Panvascular Diseases","place":["Chengde, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hebei Key Laboratory of Pathogenic Mechanisms and Diagnosis & Treatment Technologies for Lung Microbiome","place":["Zhangjiakou, Hebei, China"]},{"name":"The First Affiliated Hospital of Hebei North University","place":["Zhangjiakou, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Cangzhou Central Hospital","place":["Cangzhou, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Xingtai People\u2019s Hospital","place":["Xingtai, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmeng","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine","place":["Cangzhou, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueshan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Baoding NO.1 Hospital","place":["Baoding, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jidong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, People\u2019s Hospital of Zunhua City","place":["Zunhua, Tangshan, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Gucheng County Hospital of Hebei Province","place":["Hengshui, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hainan","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Affiliated Hospital of Chengde Medical University","place":["Chengde, Hebei, China"]},{"name":"Hebei Key Laboratory of Panvascular Diseases","place":["Chengde, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"508","DOI":"10.5578\/mb.20250438","article-title":"Determination of class-1 and class-2 integron gen casettes in klebsiella pneumoniae causing ventilator-associated pneumonia","volume":"59","author":"Am","year":"2025","journal-title":"Mikrobiyol. 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