{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T12:50:08Z","timestamp":1785934208755,"version":"3.56.0"},"reference-count":149,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Persistent infection with high-risk human papillomavirus (HR-HPV) is a prerequisite for cervical carcinogenesis. In this process, the vaginal microbiota, as a key component of the cervical microenvironment, plays a significant role in facilitating viral persistence and malignant transformation. Moving beyond the conventional focus on compositional shifts, this review systematically examines the dynamic remodeling of the host-microbiota co-metabolic network during the\u00a0progression from health to invasive cervical cancer. It explores in depth the interactive mechanisms through which metabolites derived from a dysbiotic microbiota exacerbate epithelial barrier damage, modulate local immune evasion, and activate oncogenic signaling pathways, with particular emphasis on how co-metabolic imbalance drives therapeutic resistance. By integrating these insights, this review aims to advance the mechanistic understanding of microbial contributions to cervical cancer development and to inform novel strategies for overcoming treatment resistance through microbiota-targeted interventions.<\/jats:p>","DOI":"10.3389\/fcimb.2026.1890330","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T12:39:26Z","timestamp":1785933566000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The microbiota-host metabolic axis in cervical cancer: from homeostatic disruption to mechanisms of therapy resistance"],"prefix":"10.3389","volume":"16","author":[{"given":"Yulu","family":"He","sequence":"first","affiliation":[{"name":"Genetic Diagnosis Center, The First Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Genetic Diagnosis Center, The First Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang","family":"Ju","sequence":"additional","affiliation":[{"name":"Genetic Diagnosis Center, The First Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiwen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Genetic Diagnosis Center, The First Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzhuo","family":"Si","sequence":"additional","affiliation":[{"name":"Genetic Diagnosis Center, The First Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijia","family":"Pan","sequence":"additional","affiliation":[{"name":"Genetic Diagnosis Center, The First Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Genetic Diagnosis Center, The First Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","article-title":"Gardnerella vaginalis alters cervicovaginal epithelial cell function through microbe-specific immune responses","year":"2022","DOI":"10.1186\/s40168-022-01317-9"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1093\/jac\/dkt156","article-title":"Vaginal concentrations of lactic acid potently inactivate HIV","volume":"68","author":"Aldunate","year":"2013","journal-title":"J. Antimicrob. Chemother."},{"key":"B3","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/nature12726","article-title":"Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation","volume":"504","author":"Arpaia","year":"2013","journal-title":"Nature"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2524","article-title":"Coinfections in human papillomavirus associated cancers and prophylactic recommendations","volume":"34","author":"Ashok","year":"2024","journal-title":"Rev. Med. Virol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2799","DOI":"10.1016\/j.immuni.2025.10.004","article-title":"Microbiota-derived butyrate promotes a FOXO1-induced stemness program and preserves CD8(+) T cell immunity against melanoma","volume":"58","author":"Bachem","year":"2025","journal-title":"Immunity"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01462","article-title":"CA IX stabilizes intracellular pH to maintain metabolic reprogramming and proliferation in hypoxia","volume":"10","author":"Benej","year":"2020","journal-title":"Front. Oncol."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.04435-22","article-title":"Transport and utilization of glycogen breakdown products by Gardnerella spp. from the human vaginal microbiome","volume":"11","author":"Bhandari","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"B8","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1186\/s12864-023-09665-y","article-title":"Comparative pangenomic analysis of predominant human vaginal lactobacilli strains towards population-specific adaptation: understanding the role in sustaining a balanced and healthy vaginal microenvironment","volume":"24","author":"Bhattacharya","year":"2023","journal-title":"BMC Genomics"},{"key":"B9","doi-asserted-by":"publisher","first-page":"5170","DOI":"10.1128\/IAI.67.10.5170-5175.1999","article-title":"Acid production by vaginal flora in vitro is consistent with the rate and extent of vaginal acidification","volume":"67","author":"Boskey","year":"1999","journal-title":"Infect. Immun."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.3390\/ijms20092188","article-title":"PI3K\/AKT\/mTOR signaling regulates the virus\/host cell crosstalk in HPV-positive cervical cancer cells","volume":"20","author":"Bossler","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.733619","article-title":"Antigen presenting cells link the female genital tract microbiome to mucosal inflammation, with hormonal contraception as an additional modulator of inflammatory signatures","volume":"11","author":"Byrne","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"17436","DOI":"10.1038\/s41598-025-01698-5","article-title":"LncRNA NEAT1 regulation of the miR-101-3p\/RAC1 axis affects cervical cancer aerobic glycolysis and progression","volume":"15","author":"Cao","year":"2025","journal-title":"Sci. Rep."},{"key":"B14","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/s41435-025-00338-2","article-title":"Butyrate enhances CD56(bright) NK cell-driven killing of activated T cells and modulates NK cell chromatin accessibility","volume":"26","author":"Carlini","year":"2025","journal-title":"Genes Immun."},{"key":"B15","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1002\/ijc.26476","article-title":"Lysophosphatidic acid receptor 2\/3-mediated IL-8-dependent angiogenesis in cervical cancer cells","volume":"131","author":"Chen","year":"2012","journal-title":"Int. J. Cancer"},{"key":"B16","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1038\/s41586-024-07620-9","article-title":"NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance","volume":"631","author":"Chen","year":"2024","journal-title":"Nature"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1589943","article-title":"Driving innovations in cancer research through spatial metabolomics: a bibliometric review of trends and hotspot","volume":"16","author":"Chen","year":"2025","journal-title":"Front. Immunol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"e00270","DOI":"10.1128\/mBio.00270-16","article-title":"Suppression of antitumor immune responses by human papillomavirus through epigenetic downregulation of CXCL14","volume":"7","author":"Cicchini","year":"2016","journal-title":"mBio"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.1012254","article-title":"Lactate drives cellular DNA repair capacity: role of lactate and related short-chain fatty acids in cervical cancer chemoresistance and viral infection","volume":"10","author":"Ciszewski","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1016\/j.ccell.2023.09.012","article-title":"Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring","volume":"41","author":"Colbert","year":"2023","journal-title":"Cancer Cell."},{"key":"B21","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s12866-025-03922-8","article-title":"The inferred modulation of correlated vaginal microbiota and metabolome by cervical differentially expressed genes across distinct CIN grades","volume":"25","author":"Dai","year":"2025","journal-title":"BMC Microbiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"10879","DOI":"10.1038\/s41467-024-55233-7","article-title":"Lactobacillus crispatus S-layer proteins modulate innate immune response and inflammation in the lower female reproductive tract","volume":"15","author":"Decout","year":"2024","journal-title":"Nat. Commun."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00446","article-title":"Distinct immune responses elicited from cervicovaginal epithelial cells by lactic acid and short chain fatty acids associated with optimal and non-optimal vaginal microbiota","volume":"9","author":"Delgado-Diaz","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s00404-021-06258-6","article-title":"Comparative measurement of D- and L-lactic acid isomers in vaginal secretions: association with high-grade cervical squamous intraepithelial lesions","volume":"305","author":"de Magalh\u00e3es","year":"2022","journal-title":"Arch. Gynecol. Obstet."},{"key":"B25","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1186\/s12967-024-05774-8","article-title":"The intra-tumoral microbiome as a potential biomarker of response to external beam radiation therapy in cervical cancer","volume":"22","author":"Dou","year":"2024","journal-title":"J. Transl. Med."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.01190-25","article-title":"One-year restoration of vaginal health: synergistic dynamics of microbiome and metabolome following the elimination of high-grade cervical intraepithelial neoplasia","volume":"10","author":"Du","year":"2025","journal-title":"mSystems"},{"key":"B27","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/s41419-022-04926-2","article-title":"FASN promotes lymph node metastasis in cervical cancer via cholesterol reprogramming and lymphangiogenesis","volume":"13","author":"Du","year":"2022","journal-title":"Cell Death Dis."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1577906","article-title":"The microbial metabolite butyrate enhances the effector and memory functions of murine CD8+ T cells and improves anti-tumor activity","volume":"12","author":"Gaskarth","year":"2025","journal-title":"Front. Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"e202302333","DOI":"10.26508\/lsa.202302333","article-title":"2-Hydroxyglutarate modulates histone methylation at specific loci and alters gene expression via Rph1 inhibition","volume":"7","author":"Gavriil","year":"2024","journal-title":"Life Sci. Alliance."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1126\/science.aah5043","article-title":"Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine","volume":"357","author":"Geller","year":"2017","journal-title":"Science"},{"key":"B31","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1158\/1940-6207.CAPR-23-0051","article-title":"Polymorphisms in the nonhomologous end-joining DNA repair pathway are associated with HPV integration in cervical dysplasia","volume":"16","author":"Geris","year":"2023","journal-title":"Cancer Prev. Res. Phila. Pa."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2025.189292","article-title":"Exploring the metabolic alterations in cervical cancer induced by HPV oncoproteins: From mechanisms to therapeutic targets","volume":"1880","author":"Gore","year":"2025","journal-title":"Biochim. Biophys. Acta. Rev. Cancer"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3390\/nu16152569","article-title":"Nature of the association between rheumatoid arthritis and cervical cancer and its potential therapeutic implications","volume":"16","author":"Gusakov","year":"2024","journal-title":"Nutrients"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1225652","article-title":"HPV prevalence and genotype distribution in 2,306 patients with cervical squamous cell carcinoma in central and eastern China","volume":"11","author":"Han","year":"2023","journal-title":"Front. Public Health"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1038\/mi.2017.27","article-title":"Vaginal lactic acid elicits an anti-inflammatory response from human cervicovaginal epithelial cells and inhibits production of pro-inflammatory mediators associated with HIV acquisition","volume":"10","author":"Hearps","year":"2017","journal-title":"Mucosal Immunol."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105590","article-title":"Genetic elements orchestrating Lactobacillus crispatus glycogen metabolism in the vagina","volume":"23","author":"Hertzberger","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"106342","DOI":"10.18632\/oncotarget.22463","article-title":"Viral E6\/E7 oncogene and cellular hexokinase 2 expression in HPV-positive cancer cell lines","volume":"8","author":"Hoppe-Seyler","year":"2017","journal-title":"Oncotarget"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13051174","article-title":"Carbonic anhydrase IX promotes human cervical cancer cell motility by regulating PFKFB4 expression","volume":"13","author":"Hsin","year":"2021","journal-title":"Cancers"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1186\/s12967-025-06928-y","article-title":"Colonization by Porphyromonas gingivalis in cervical squamous cell carcinomas promotes metastasis through FimA\/CD151\/ITGB1 signaling","volume":"23","author":"Huang","year":"2025","journal-title":"J. Transl. Med."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2021.103454","article-title":"Combination of IDO1(high) and CCL19(low) expression in the tumor tissue reduces survival in HPV positive cervical cancer","volume":"149","author":"Jayakumar","year":"2022","journal-title":"J. Reprod. Immunol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1038\/s41564-023-01447-2","article-title":"Bacterial amylases enable glycogen degradation by the vaginal microbiome","volume":"8","author":"Jenkins","year":"2023","journal-title":"Nat. Microbiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1186\/s40001-023-01490-z","article-title":"Research progress of metabolomics in cervical cancer","volume":"28","author":"Jia","year":"2023","journal-title":"Eur. J. Med. Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1093\/infdis\/jiae533","article-title":"Immunometabolic contributions of Atopobiaceae family members in human papillomavirus infection, cervical dysplasia, and cancer","volume":"232","author":"Jimenez","year":"2025","journal-title":"J. Infect. Dis."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/j.rbmo.2023.02.002","article-title":"Comparative analysis of the vaginal microbiome of healthy and polycystic ovary syndrome women: a large cross-sectional study","volume":"46","author":"Jin","year":"2023","journal-title":"Reprod. Biomed. Online"},{"key":"B45","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.trecan.2024.01.001","article-title":"Bacteria-derived L-lactate fuels cervical cancer chemoradiotherapy resistance","volume":"10","author":"Johnston","year":"2024","journal-title":"Trends Cancer"},{"key":"B46","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/s41522-025-00747-1","article-title":"Metagenomic insight into the vaginal microbiome in women infected with HPV 16 and 18","volume":"11","author":"Jung","year":"2025","journal-title":"NPJ Biofilms. Microbiomes."},{"key":"B47","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1136\/gutjnl-2023-330291","article-title":"Roseburia intestinalis generated butyrate boosts anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8(+) T cells","volume":"72","author":"Kang","year":"2023","journal-title":"Gut"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.00551","article-title":"Crosstalk between female gonadal hormones and vaginal microbiota across various phases of women\u2019s gynecological lifecycle","volume":"11","author":"Kaur","year":"2020","journal-title":"Front. Microbiol."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1589277","article-title":"Distinct cervical microbiome and metabolite profiles before and after menopause: implications for cervical cancer progression","volume":"15","author":"Kawasaki","year":"2025","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16162817","article-title":"Lactate oxidase disrupts lactate-activated RAS and PI3K oncogenic signaling","volume":"16","author":"Keller","year":"2024","journal-title":"Cancers"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1637098","article-title":"Microbiota-immune dysregulation in cervical cancer patients from Western Mexico: linking gut dysbiosis and NK cell exhaustion as promising biomarkers","volume":"16","author":"Klimov-Kravtchenko","year":"2025","journal-title":"Front. Immunol."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00299-25","article-title":"Genetic transformation of Gardnerella species and characterization of vaginolysin and sialidase mutants","volume":"93","author":"Klimowicz","year":"2025","journal-title":"Infect. Immun."},{"key":"B53","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1111\/j.1349-7006.2011.01878.x","article-title":"Prevalence and type distribution of human papillomavirus in healthy Japanese women aged 20 to 25 years old enrolled in a clinical study","volume":"102","author":"Konno","year":"2011","journal-title":"Cancer Sci."},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218266","article-title":"The cervicovaginal mucus barrier","volume":"21","author":"Lacroix","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27020640","article-title":"The vaginal microbiome and host health: implications for cervical cancer progression","volume":"27","author":"Lagunas-Cruz","year":"2026","journal-title":"Int. J. Mol. Sci."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00499-24","article-title":"Exploring the vaginal ecosystem: insights into host-microbe interactions and microbial community dynamics","volume":"93","author":"Landolt","year":"2025","journal-title":"Infect. Immun."},{"key":"B57","doi-asserted-by":"publisher","first-page":"7593","DOI":"10.1038\/s41598-018-25879-7","article-title":"Linking cervicovaginal immune signatures, HPV and microbiota composition in cervical carcinogenesis in non-Hispanic and Hispanic women","volume":"8","author":"\u0141aniewski","year":"2018","journal-title":"Sci. Rep."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1038\/s41467-022-28724-8","article-title":"HPV infection alters vaginal microbiome through down-regulating host mucosal innate peptides used by Lactobacilli as amino acid sources","volume":"13","author":"Lebeau","year":"2022","journal-title":"Nat. Commun."},{"key":"B59","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.ygyno.2007.10.034","article-title":"Roles for hypoxia-regulated genes during cervical carcinogenesis: somatic evolution during the hypoxia-glycolysis-acidosis sequence","volume":"108","author":"Lee","year":"2008","journal-title":"Gynecol. Oncol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1186\/s12964-025-02366-x","article-title":"Lactylation modification of HIF-1\u03b1 enhances its stability by blocking VHL recognition","volume":"23","author":"Li","year":"2025","journal-title":"Cell. Commun. Signal. CCS."},{"key":"B61","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s12986-021-00615-7","article-title":"Metabolic reprogramming in cervical cancer and metabolomics perspectives","volume":"18","author":"Li","year":"2021","journal-title":"Nutr. Metab."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1155\/mi\/2582989","article-title":"Integrative analysis of shared pathogenic genes and potential mechanisms in Gardnerella vaginalis and persistent HPV16 infection","volume":"2025","author":"Li","year":"2025","journal-title":"Mediators Inflamm."},{"key":"B63","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.it.2021.07.005","article-title":"Lipid regulation of NLRP3 inflammasome activity through organelle stress","volume":"42","author":"Liang","year":"2021","journal-title":"Trends Immunol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/s41419-026-08589-1","article-title":"Lactylation stabilizes PD-L1 to promote tumor immune evasion and cell growth","volume":"17","author":"Liang","year":"2026","journal-title":"Cell Death Dis."},{"key":"B65","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s12985-025-02731-9","article-title":"HPV16 E7 inhibits HBD2 expression by down-regulation of ASK1-p38 MAPK pathway in cervical cancer","volume":"22","author":"Liao","year":"2025","journal-title":"Virol. J."},{"key":"B66","doi-asserted-by":"publisher","first-page":"2812","DOI":"10.1038\/s41598-022-06731-5","article-title":"Changes of the vaginal microbiota in HPV infection and cervical intraepithelial neoplasia: a cross-sectional analysis","volume":"12","author":"Lin","year":"2022","journal-title":"Sci. Rep."},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110792","article-title":"The lactate-NAD(+) axis activates cancer-associated fibroblasts by downregulating p62","volume":"39","author":"Linares","year":"2022","journal-title":"Cell Rep."},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202500354","article-title":"FOXP3 polymorphism and upregulation of the CXCL12-CXCR4-SNAIL axis with high infiltration of M2TAM by STAT3\/NFKB pathways influence the survival of cervical cancer patients","volume":"9","author":"Lira","year":"2025","journal-title":"Adv. Biol."},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2025.106532","article-title":"Gram-negative intratumoral bacteria mediate lymph node metastasis through LPS-TLR4\/MAPK signaling pathway in cervical cancer","volume":"91","author":"Liu","year":"2025","journal-title":"J. Infect."},{"key":"B70","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.cmet.2024.11.005","article-title":"Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis","volume":"37","author":"Liu","year":"2025","journal-title":"Cell Metab."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1186\/s12885-024-13275-6","article-title":"Metabolism and spatial transcription resolved heterogeneity of glutamine metabolism in cervical carcinoma","volume":"24","author":"Liu","year":"2024","journal-title":"BMC Cancer"},{"key":"B72","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1016\/j.apsb.2023.03.025","article-title":"The suppression of cervical cancer ferroptosis by macrophages: the attenuation of ALOX15 in cancer cells by macrophages-derived exosomes","volume":"13","author":"Luo","year":"2023","journal-title":"Acta Pharm. Sin. B."},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1033040","article-title":"Biofilm and pathogenic factor analysis of Gardnerella vaginalis associated with bacterial vaginosis in Northeast China","volume":"13","author":"Ma","year":"2022","journal-title":"Front. Microbiol."},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11102407","article-title":"Microbiota transplant and gynecological disorders: the bridge between present and future treatments","volume":"11","author":"Martinelli","year":"2023","journal-title":"Microorganisms"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1634388","article-title":"HIV-associated gut dysbiosis drives oncogenesis through metabolic-immune crosstalk: mechanisms and therapeutic implications","volume":"15","author":"Meng","year":"2025","journal-title":"Front. Oncol."},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103108","article-title":"Human papillomavirus-16 E6 activates the pentose phosphate pathway to promote cervical cancer cell proliferation by inhibiting G6PD lactylation","volume":"71","author":"Meng","year":"2024","journal-title":"Redox Biol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"3190","DOI":"10.4049\/jimmunol.0903670","article-title":"An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells","volume":"185","author":"Mezrich","year":"2010","journal-title":"J. Immunol. Baltim. Md. 1950"},{"key":"B78","doi-asserted-by":"publisher","first-page":"6714","DOI":"10.1038\/s41598-022-09980-6","article-title":"TLR4 and SARM1 modulate survival and chemoresistance in an HPV-positive cervical cancer cell line","volume":"12","author":"Morale","year":"2022","journal-title":"Sci. Rep."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007835","article-title":"Autocrine STAT3 activation in HPV positive cervical cancer through a virus-driven Rac1-NF\u03baB-IL-6 signalling axis","volume":"15","author":"Morgan","year":"2019","journal-title":"PloS Pathog."},{"key":"B80","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1038\/s41467-025-57323-6","article-title":"Microbial metabolites control self-renewal and precancerous progression of human cervical stem cells","volume":"16","author":"Myeong","year":"2025","journal-title":"Nat. Commun."},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.001685","article-title":"Ligand-binding properties of substrate binding proteins of a maltose uptake system in Gardnerella swidsinskii","volume":"172","author":"Nguyen","year":"2026","journal-title":"Microbiol. Read. Engl."},{"key":"B82","doi-asserted-by":"publisher","first-page":"7173","DOI":"10.3390\/ijms24087173","article-title":"Bacterial species from vaginal microbiota differently affect the production of the E6 and E7 oncoproteins and of p53 and p-Rb oncosuppressors in HPV16-infected cells","volume":"24","author":"Nicol\u00f2","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B83","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/s42255-025-01287-w","article-title":"The gut microbiome and cancer: from tumorigenesis to therapy","volume":"7","author":"Nobels","year":"2025","journal-title":"Nat. Metab."},{"key":"B84","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1136\/sextrans-2021-055057","article-title":"Prevalence of curable STIs and bacterial vaginosis during pregnancy in sub-Saharan Africa: a systematic review and meta-analysis","volume":"98","author":"Nyemba","year":"2022","journal-title":"Sex. Transm. Infect."},{"key":"B85","doi-asserted-by":"publisher","first-page":"2729","DOI":"10.31557\/APJCP.2021.22.9.2729","article-title":"Racial disparities associated with the prevalence of vaccine and non-vaccine HPV types and multiple HPV infections between Asia and Africa: a systematic review and meta-analysis","volume":"22","author":"Okoye","year":"2021","journal-title":"Asian Pac. J. Cancer Prev. APJCP."},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2025.1665666","article-title":"The global response to HIV\/AIDS in sub-Saharan Africa: achievements, challenges, and perspectives for the future","volume":"13","author":"Orlando","year":"2025","journal-title":"Front. Public Health"},{"key":"B87","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1086\/318070","article-title":"Assessment of the capacity of Lactobacillus to inhibit the growth of uropathogens and block their adhesion to vaginal epithelial cells","volume":"183","author":"Osset","year":"2001","journal-title":"J. Infect. Dis."},{"key":"B88","doi-asserted-by":"publisher","first-page":"17718","DOI":"10.1038\/s41598-021-96038-8","article-title":"Metabolic rewiring is associated with HPV-specific profiles in cervical cancer cell lines","volume":"11","author":"Pappa","year":"2021","journal-title":"Sci. Rep."},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2400341121","article-title":"Prevotella are major contributors of sialidases in the human vaginal microbiome","volume":"121","author":"Pelayo","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.00683-25","article-title":"Lactobacillus crispatus-derived nCEV vesicles promote cutaneous wound healing and inhibit HPV16 infection","volume":"10","author":"Peng","year":"2025","journal-title":"mSystems"},{"key":"B91","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1186\/s12879-025-10851-4","article-title":"Associations of Atopobium, Garderella, Megasphaera, Prevotella, Sneathia, and Streptococcus with human papillomavirus infection, cervical intraepithelial neoplasia, and cancer: a systematic review and meta-analysis","volume":"25","author":"Peng","year":"2025","journal-title":"BMC Infect. Dis."},{"key":"B92","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1038\/s41590-024-01999-3","article-title":"Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism","volume":"25","author":"Peralta","year":"2024","journal-title":"Nat. Immunol."},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00192-25","article-title":"Microbial and metabolic profiles associated with HPV infection and cervical intraepithelial neoplasia: a multi-omics study","volume":"13","author":"Pu","year":"2025","journal-title":"Microbiol. Spectr."},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.19072","article-title":"TGF-\u03b2-mediated activation of fibroblasts in cervical cancer: implications for tumor microenvironment and prognosis","volume":"13","author":"Qu","year":"2025","journal-title":"PeerJ"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.1042663","article-title":"A systematic assessment of stress insomnia as the high-risk factor for cervical cancer and interplay of cervicovaginal microbiome","volume":"12","author":"Rai","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.732423","article-title":"The effect of exogenous sex steroids on the vaginal microbiota: a systematic review","volume":"11","author":"Ratten","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1369\/00221554221101662","article-title":"GLUT1, LDHA, and MCT4 expression is deregulated in cervical cancer and precursor lesions","volume":"70","author":"Reyna-Hern\u00e1ndez","year":"2022","journal-title":"J. Histochem. Cytochem. Off. J. Histochem. Soc"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.14449","article-title":"Insights into the vaginal microbiome in a diverse group of women of African, Asian and European ancestries","volume":"10","author":"Roachford","year":"2022","journal-title":"PeerJ"},{"key":"B99","doi-asserted-by":"publisher","first-page":"301","DOI":"10.3892\/ijo.2020.5039","article-title":"CDH1 and SNAI1 are regulated by E7 from human papillomavirus types 16 and 18","volume":"57","author":"Rosendo-Chalma","year":"2020","journal-title":"Int. J. Oncol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"4375","DOI":"10.1002\/ptr.7937","article-title":"Recent insights into the nutritional immunomodulation of cancer-related microRNAs","volume":"37","author":"\u015eahin","year":"2023","journal-title":"Phytother. Res. PTR."},{"key":"B101","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.2147\/OTT.S278089","article-title":"The association between inflammation and immunosuppression: implications for ICI biomarker development","volume":"14","author":"Sacdalan","year":"2021","journal-title":"OncoTargets. Ther."},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1335975","article-title":"Probiotic lactic acid bacteria promote anti-tumor immunity through enhanced major histocompatibility complex class I-restricted antigen presentation machinery in dendritic cells","volume":"15","author":"Saito","year":"2024","journal-title":"Front. Immunol."},{"key":"B103","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s12195-020-00652-x","article-title":"Lactate exposure promotes immunosuppressive phenotypes in innate immune cells","volume":"13","author":"Sangsuwan","year":"2020","journal-title":"Cell. Mol. Bioeng."},{"key":"B104","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1038\/s41586-023-06409-6","article-title":"Lactate limits CNS autoimmunity by stabilizing HIF-1\u03b1 in dendritic cells","volume":"620","author":"Sanmarco","year":"2023","journal-title":"Nature"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1586442","article-title":"The activity of cell-free supernatant of Lactobacillus crispatus M247: a promising treatment against vaginal infections","volume":"15","author":"Santarelli","year":"2025","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/s41422-020-0301-1","article-title":"Signaling\u00a0networks in immunometabolism","volume":"30","author":"Saravia","year":"2020","journal-title":"Cell Res."},{"key":"B107","doi-asserted-by":"publisher","first-page":"20065","DOI":"10.1038\/s41598-023-47172-y","article-title":"Lactic acid enhances vaginal epithelial barrier integrity and ameliorates inflammatory effects of dysbiotic short chain fatty acids and HIV-1","volume":"13","author":"Schwecht","year":"2023","journal-title":"Sci. Rep."},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.1173","article-title":"Antimicrobial properties of Lactobacillus cell-free supernatants against multidrug-resistant urogenital pathogens","volume":"10","author":"Scillato","year":"2021","journal-title":"Microbiol. Open"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2025.110936","article-title":"Effect of contraceptive methods on the vaginal microbiome and host immune factors","volume":"148","author":"Serrano","year":"2025","journal-title":"Contraception"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00390-22","article-title":"Gardnerella revisited: Species heterogeneity, virulence factors, mucosal immune responses, and contributions to bacterial vaginosis","volume":"91","author":"Shvartsman","year":"2023","journal-title":"Infect. Immun."},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2025.1633283","article-title":"Human papillomavirus-mediated cervical cancer: epigenetic interplay and clinical implications","volume":"16","author":"Sisodiya","year":"2025","journal-title":"Front. Microbiol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"2667","DOI":"10.3390\/ijms21082667","article-title":"HPV infection significantly accelerates glycogen metabolism in cervical cells with large nuclei: Raman microscopic study with subcellular resolution","volume":"21","author":"Sitarz","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/598386","article-title":"Lysophosphatidic acid inhibits apoptosis induced by cisplatin in cervical cancer cells","volume":"2015","author":"Sui","year":"2015","journal-title":"BioMed. Res. Int."},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00651","article-title":"Role of proton-coupled monocarboxylate transporters in cancer: From metabolic crosstalk to therapeutic potential","volume":"8","author":"Sun","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.7150\/ijbs.105572","article-title":"SERINC2-mediated serine metabolism promotes cervical cancer progression and drives T cell exhaustion","volume":"21","author":"Sun","year":"2025","journal-title":"Int. J. Biol. Sci."},{"key":"B116","doi-asserted-by":"publisher","first-page":"9720","DOI":"10.1038\/s41598-020-66607-4","article-title":"Taxonomic and functional differences in cervical microbiome associated with cervical cancer development","volume":"10","author":"Tango","year":"2020","journal-title":"Sci. Rep."},{"key":"B117","doi-asserted-by":"publisher","first-page":"6098","DOI":"10.3390\/ijms22116098","article-title":"Inhibition of carbonic anhydrase IX promotes apoptosis through intracellular pH level alterations in cervical cancer cells","volume":"22","author":"Temiz","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B118","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s12964-015-0114-x","article-title":"L- and D-lactate enhance DNA repair and modulate the resistance of cervical carcinoma cells to anticancer drugs via histone deacetylase inhibition and hydroxycarboxylic acid receptor 1 activation","volume":"13","author":"Wagner","year":"2015","journal-title":"Cell. Commun. Signal. CCS."},{"key":"B119","first-page":"555","article-title":"The lactate receptor (HCAR1\/GPR81) contributes to doxorubicin chemoresistance via ABCB1 transporter up-regulation in human cervical cancer HeLa cells","volume":"68","author":"Wagner","year":"2017","journal-title":"J. Physiol. Pharmacol. Off. J. Pol. Physiol. Soc"},{"key":"B120","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.dnarep.2017.02.007","article-title":"Stimulation of lactate receptor (HCAR1) affects cellular DNA repair capacity","volume":"52","author":"Wagner","year":"2017","journal-title":"DNA Repair"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222413194","article-title":"Lactate suppresses retroviral transduction in cervical epithelial cells through DNA-PKcs modulation","volume":"22","author":"Wagner","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.70296","article-title":"Serinc2 drives the progression of cervical cancer through regulating Myc pathway","volume":"13","author":"Wang","year":"2024","journal-title":"Cancer Med."},{"key":"B123","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s11658-025-00712-y","article-title":"CircNF1 modulates the progression and immune evasion of esophageal squamous cell carcinoma through dual regulation of PD-L1","volume":"30","author":"Wang","year":"2025","journal-title":"Cell. Mol. Biol. Lett."},{"key":"B124","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1093\/cid\/ciac938","article-title":"Non-Lactobacillus-dominant and polymicrobial vaginal microbiomes are more common in younger South African women and predictive of increased risk of human immunodeficiency virus acquisition","volume":"76","author":"Wang","year":"2023","journal-title":"Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc Am."},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202200028","article-title":"Butyrate drives metabolic rewiring and epigenetic reprogramming in human colon cancer cells","volume":"66","author":"Wang","year":"2022","journal-title":"Mol. Nutr. Food Res."},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2025.107695","article-title":"TPI1 promotes p53 ubiquitination in bladder cancer by recruiting AKT to enhance MDM2 phosphorylation","volume":"215","author":"Wang","year":"2025","journal-title":"Pharmacol. Res."},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.3390\/cells15121073","article-title":"Metabolic reprogramming-driven lactylation: emerging mechanisms linking DNA damage repair and chemoresistance in cancer","volume":"15","author":"Wang","year":"2026","journal-title":"Cells"},{"key":"B128","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/S0140-6736(24)01097-3","article-title":"Causal attribution of human papillomavirus genotypes to invasive cervical cancer worldwide: a systematic analysis of the global literature","volume":"404","author":"Wei","year":"2024","journal-title":"Lancet Lond. Engl."},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2023.102151","article-title":"PSME3 induces radioresistance and enhances aerobic glycolysis in cervical cancer by regulating PARP1","volume":"83","author":"Wei","year":"2023","journal-title":"Tissue Cell."},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00460-13","article-title":"Influence of vaginal bacteria and D- and L-lactic acid isomers on vaginal extracellular matrix metalloproteinase inducer: implications for protection against upper genital tract infections","volume":"4","author":"Witkin","year":"2013","journal-title":"mBio"},{"key":"B131","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/s41570-023-00471-4","article-title":"Targeting the human gut microbiome with small-molecule inhibitors","volume":"7","author":"Woo","year":"2023","journal-title":"Nat. Rev. Chem."},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2025.10029","article-title":"Microbiome-driven resistance in cervical cancer therapy: from mechanistic dissection to clinical translation","volume":"28","author":"Wu","year":"2025","journal-title":"Expert Rev. Mol. Med."},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1024723","article-title":"Leveraging 16S rRNA data to uncover vaginal microbial signatures in women with cervical cancer","volume":"13","author":"Wu","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B134","first-page":"3943","article-title":"Long non-coding RNA UCA1 modulates the glycolysis of cervical cancer cells by miR-493-5p\/HK2","volume":"11","author":"Wu","year":"2018","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1186\/s12943-025-02482-9","article-title":"Purine metabolism: a pan-cancer metabolic dysregulation across circulation and tissues","volume":"24","author":"Yu","year":"2025","journal-title":"Mol. Cancer"},{"key":"B136","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/s12943-024-02055-2","article-title":"NSUN6-mediated 5-methylcytosine modification of NDRG1 mRNA promotes radioresistance in cervical cancer","volume":"23","author":"Yu","year":"2024","journal-title":"Mol. Cancer"},{"key":"B137","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.3724\/abbs.2022109","article-title":"Inhibition of the PIN1-NRF2\/GPX4 axis imparts sensitivity to cisplatin in cervical cancer cells","volume":"54","author":"Zhang","year":"2022","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"B138","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3892\/ijmm.2025.5693","article-title":"Human papillomavirus E7 inhibits immune responses in keratinocytes by activating HTRA1-mediated mitophagy","volume":"57","author":"Zhang","year":"2026","journal-title":"Int. J. Mol. Med."},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2026.116213","article-title":"Succinate-mediated activation of the GPR91\/MALT1\/NF-\u03baB\/CCL2 pathway in macrophages contributes to pulmonary fibrosis","volume":"172","author":"Zhang","year":"2026","journal-title":"Int. Immunopharmacol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1007\/s10735-025-10570-9","article-title":"Role of indoleamine 2,3-dioxygenase 1 in modulating the Malignant biological behavior of cervical cancer cells through the tryptophan-kynurenine pathway","volume":"56","author":"Zhang","year":"2025","journal-title":"J. Mol. Histol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s12866-024-03244-1","article-title":"HPV-associated cervicovaginal microbiome and host metabolome characteristics","volume":"24","author":"Zhang","year":"2024","journal-title":"BMC Microbiol."},{"key":"B142","first-page":"663","article-title":"UDP-glucose ceramide glycosyltransferase contributes to the proliferation and glycolysis of cervical cancer cells by regulating the PI3K\/AKT pathway","volume":"51","author":"Zhang","year":"2021","journal-title":"Ann. Clin. Lab. Sci."},{"key":"B143","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1016\/j.cmet.2023.04.015","article-title":"Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8(+) T cell immunity","volume":"35","author":"Zhang","year":"2023","journal-title":"Cell Metab."},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-025-02662-8","article-title":"Lactobacillus gasseri LGV03-derived indole-3-lactic acid ameliorates immune response by activating aryl hydrocarbon receptor","volume":"24","author":"Zhang","year":"2025","journal-title":"Microb. Cell. Factories."},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.817957","article-title":"Acidic electrolyzed water inhibits the viability of Gardnerella spp. via oxidative stress response","volume":"9","author":"Zhao","year":"2022","journal-title":"Front. Med."},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110991","article-title":"Global pattern of persistent human papillomavirus infection in female genital tract: An update system review and meta-analysis","volume":"27","author":"Zhao","year":"2024","journal-title":"iScience"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-024-01529-6","article-title":"FFAR2 expressing myeloid-derived suppressor cells drive cancer immunoevasion","volume":"17","author":"Zhao","year":"2024","journal-title":"J. Hematol. OncolJ. Hematol. Oncol."},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202512599","article-title":"Erucic acid, derived by Lactobacillus crispatus, induces ferroptosis in cervical cancer organoids through the PPAR-\u03b4 signaling pathway","volume":"12","author":"Zhen","year":"2025","journal-title":"Adv. Sci. Weinh. Baden-Wurtt. Ger."},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e35736","article-title":"Patterns of single and multiple HPV infections in female: A systematic review and meta-analysis","volume":"10","author":"Zhou","year":"2024","journal-title":"Heliyon"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2026.1890330\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T12:39:28Z","timestamp":1785933568000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2026.1890330\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,5]]},"references-count":149,"alternative-id":["10.3389\/fcimb.2026.1890330"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2026.1890330","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,5]]},"article-number":"1890330"}}