{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:12:17Z","timestamp":1788415937442,"version":"build-2803163510"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>In winter 2025, a severe respiratory disease outbreak occurred in brown cattle in Yili, Xinjiang, China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We detected bovine parainfluenza virus type 3 (BPIV-3) in all clinical samples from affected animals and successfully isolated the virus. Whole-genome sequencing and phylogenetic analysis classified the isolates as genotype C, which is currently the predominant lineage circulating in Chinese cattle herds. Importantly, the key antigenic epitopes of the HN and F proteins were fully conserved compared with the approved vaccine strain SD0835.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides the first molecular evidence of BPIV-3 genotype C as the causative agent of a respiratory disease outbreak in brown cattle in Xinjiang, and the epitope conservation suggests that the existing vaccine may offer cross-protective efficacy. Our findings underscore the need for enhanced surveillance and prompt implementation of preventive strategies in this region.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1901710","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:13:51Z","timestamp":1788412431000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Isolation and Characterization of bovine parainfluenza virus type 3 genotype C from brown cattle with respiratory disease in Yili, Xinjiang, China"],"prefix":"10.3389","volume":"16","author":[{"given":"Xiuyu","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Xinjiang Agricultural University","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Xinjiang Agricultural University","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiling","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Xinjiang Agricultural University","place":["Urumqi, China"]},{"name":"Aksu Regional Animal Disease Control and Diagnostic Center","place":["Aksu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Fu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Xinjiang Agricultural University","place":["Urumqi, China"]},{"name":"Sino-science Gene Biological Technology Co.","place":["Ltd, Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"zhang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Xinjiang Agricultural University","place":["Urumqi, China"]},{"name":"Aksu Regional Animal Disease Control and Diagnostic Center","place":["Aksu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xintong","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Xinjiang Agricultural University","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Key laboratory for animal disease detection, College of Animal Sciences, Yili Vocational and Technical College","place":["Yili, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxin","family":"Xie","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Xinjiang Agricultural University","place":["Urumqi, China"]},{"name":"Xinjiang Key Laboratory of New Drug Research and Development for Herbivores","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panpan","family":"Tong","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Xinjiang Agricultural University","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2026.1720214","article-title":"Molecular investigation and viral load analysis of bovine respiratory syncytial virus in cattle with bovine respiratory disease complex in Inner Mongolia, China","volume":"16","author":"Ban","year":"2026","journal-title":"Front. 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