{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:13:43Z","timestamp":1786115623275,"version":"build-2736575974"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Acne vulgaris (AV) is a chronic inflammatory skin disorder with multifactorial etiology involving host\u2013microbiome interactions. While cutaneous dysbiosis has been extensively studied, the contribution of the gut microbiome and its potential interaction with the skin microbiome remains insufficiently characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this pilot study, paired facial skin swabs and stool samples were collected from 17 patients with moderate-to-severe AV and 14 healthy controls. Microbial DNA was extracted and the V3\u2013V4 regions of the bacterial 16S rRNA gene were sequenced on the Illumina MiSeq platform.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Acne patients exhibited significantly reduced gut microbial alpha diversity compared to controls (p &amp;lt; 0.001 across indices), accompanied by decreased diversity in the skin microbiome. Beta diversity analyses revealed distinct gut microbial community structures between groups, whereas skin microbial composition showed more subtle differences. Taxonomic profiling identified pronounced alterations in gut microbiota, contrasting with relatively modest shifts in skin communities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings reveal a systemic pattern of microbial dysbiosis in AV, characterized by marked alterations in the gut microbiome alongside concurrent, albeit less pronounced, changes in the skin microbiome. These results support a role for the gut\u2013skin axis in acne pathophysiology and highlight the need for integrative, system-level analyses of host\u2013microbiome interactions in inflammatory skin diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1904271","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T04:24:34Z","timestamp":1785990274000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Gut and skin dysbiosis in acne vulgaris: a comparative microbiome analysis"],"prefix":"10.3389","volume":"16","author":[{"given":"Agata","family":"Lesiak","sequence":"first","affiliation":[{"name":"Institute of Medical Science, Collegium Medicum, Jan Kochanowski University","place":["Kielce, Poland"]},{"name":"Department of Microbiology, Provincial Combined Hospital in Kielce","place":["Kielce, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Krawczyk","sequence":"additional","affiliation":[{"name":"Department of Molecular Medical Microbiology, Chair of Microbiology, Jagiellonian University Medical College","place":["Krak\u00f3w, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Piasta","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Provincial Combined Hospital in Kielce","place":["Kielce, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Spa\u0142ek","sequence":"additional","affiliation":[{"name":"Institute of Medical Science, Collegium Medicum, Jan Kochanowski University","place":["Kielce, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Szajkowska","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Provincial Combined Hospital in Kielce","place":["Kielce, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Papros","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, Provincial Combined Hospital in Kielce","place":["Kielce, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Kr\u0119cisz","sequence":"additional","affiliation":[{"name":"Institute of Medical Science, Collegium Medicum, Jan Kochanowski University","place":["Kielce, Poland"]},{"name":"Dermatology Clinic, Provincial Combined Hospital in Kielce","place":["Kielce, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonita","family":"Durna\u015b","sequence":"additional","affiliation":[{"name":"Institute of Medical Science, Collegium Medicum, Jan Kochanowski University","place":["Kielce, Poland"]},{"name":"Department of Clinical Microbiology, Holy-Cross Oncology Center of Kielce","place":["Kielce, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Gosiewski","sequence":"additional","affiliation":[{"name":"Microbiome Research Laboratory, Department of Molecular Medical Microbiology, Chair of Microbiology, Faculty of Medicine, Jagiellonian University Medical College","place":["Krak\u00f3w, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bucki","sequence":"additional","affiliation":[{"name":"Institute of Medical Science, Collegium Medicum, Jan Kochanowski University","place":["Kielce, Poland"]},{"name":"Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bia\u0142ystok","place":["Bia\u0142ystok, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1111\/bjd.17085","article-title":"Why we continue to use the name Propionibacterium acnes","volume":"179","author":"Alexeyev","year":"2018","journal-title":"Br. 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