{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:04:17Z","timestamp":1789707857322,"version":"4.0.1"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study evaluated the predictive value of antiphospholipid antibodies (aPLs) combined with the adjusted global antiphospholipid syndrome score (aGAPSS) for thrombosis in hospitalized systemic lupus erythematosus (SLE) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis included 309 SLE patients (65 with in-hospital thrombosis, 244 without). Demographic, clinical, and serological data were collected. Least absolute shrinkage and selection operator (LASSO) regression and multivariate logistic regression identified independent risk factors. A combined predictive model was constructed and internally validated using bootstrap.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with thrombosis were older, had higher smoking prevalence, LA ratio, and aGAPSS (all\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.05). Disease activity was significantly higher in the thrombosis group, as reflected by a higher mean SLEDAI score (14.29 \u00b1 2.88 vs. 12.45 \u00b1 1.62,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.001). Multivariate analysis identified age (OR\u00a0=\u00a01.053), smoking (OR\u00a0=\u00a02.945), SLEDAI (OR\u00a0=\u00a01.312), LA ratio (OR\u00a0=\u00a017.432), and aGAPSS (OR\u00a0=\u00a01.514) as independent predictors. The combined model (aGAPSS + clinical covariates) achieved an area under the curve (AUC) of 0.832, significantly outperforming aGAPSS alone (AUC\u00a0=\u00a00.693; \u0394AUC = 0.139,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.001), with NRI of 0.356 and IDI of 0.142.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Integrating aGAPSS with clinical factors provides good discriminative ability for in-hospital thrombosis risk stratification in hospitalized SLE patients, offering a practical tool that may inform surveillance intensity and prophylactic consideration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1909515","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:36:41Z","timestamp":1789706201000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The predictive value of aGAPSS score combined with clinical factors for thrombosis in systemic lupus erythematosus"],"prefix":"10.3389","volume":"16","author":[{"given":"Juan","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Henan Provincial People\u2019s Hospital","place":["Zhengzhou, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libo","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, Zhumadian Central Hospital","place":["Zhumadian, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Henan Provincial People\u2019s Hospital","place":["Zhengzhou, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiming","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Henan Provincial People\u2019s Hospital","place":["Zhengzhou, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"B9","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1007\/s11845-023-03519-y","article-title":"Non-criteria autoantibodies in antiphospholipid syndrome may be associated with underlying disease activity","volume":"193","author":"Aky\u00fcz Da\u011fl\u0131","year":"2024","journal-title":"Ir. 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