{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:01:38Z","timestamp":1790226098207,"version":"4.1.0"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82560302"],"award-info":[{"award-number":["82560302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["202501AY070001-186"],"award-info":[{"award-number":["202501AY070001-186"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005147","name":"Applied Basic Research Key Project of Yunnan Province","doi-asserted-by":"publisher","award":["202601AT070281"],"award-info":[{"award-number":["202601AT070281"]}],"id":[{"id":"10.13039\/501100005147","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Vulvovaginal candidiasis (VVC) is a common infection of the female reproductive tract and is closely associated with dysregulated mucosal immunity. This study investigated how IL-17A\/TNFSF10 signaling regulates neutrophil death and VVC progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical specimens, RNA sequencing, cell-based assays, and mouse models were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      IL-17A enhanced neutrophil extracellular trap formation and increased TNFSF10\/TNFRSF10 expression, together with increased phosphorylation of RIP3 and MLKL.\n                      <jats:italic>In vivo<\/jats:italic>\n                      , IL-17A aggravated mucosal injury and neutrophil infiltration, whereas TNFSF10 manipulation altered neutrophil accumulation, inflammatory responses, and epithelial barrier function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings suggest that IL-17A\/TNFSF10 signaling contributes to neutrophil death, mucosal inflammation, and VVC progression. Targeting this pathway may represent a potential therapeutic strategy for VVC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1910964","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:34:07Z","timestamp":1790224447000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The IL-17A\/TNFSF10 axis promotes vulvovaginal candidiasis pathogenesis by inducing neutrophil necroptosis"],"prefix":"10.3389","volume":"16","author":[{"given":"Mingkun","family":"SHAO","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Kunming Medical University","place":["Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqin","family":"HU","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Kunming Medical University","place":["Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxiao","family":"FENG","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Kunming Medical University","place":["Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sainan","family":"LI","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The First Affiliated Hospital of Kunming Medical University","place":["Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjin","family":"QI","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The First Affiliated Hospital of Kunming Medical University","place":["Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"LIU","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Kunming Medical University","place":["Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15061773","article-title":"The impact of TRAIL on the immunological milieu during the early stage of abdominal sepsis","volume":"15","author":"Berg","year":"2023","journal-title":"Cancers"},{"key":"B2","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/s41586-025-09523-9","article-title":"Myeloperoxidase transforms chromatin into neutrophil extracellular traps","volume":"647","author":"Burn","year":"2025","journal-title":"Nature"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.113558","article-title":"Cineole alleviates the BPA-inhibited NETs formation by regulating the p38 pathway-mediated programmed cell death","volume":"237","author":"Chen","year":"2022","journal-title":"Ecotoxicology Environ. 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