{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T04:56:12Z","timestamp":1790571372069,"version":"4.1.0"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To conduct a three-year cervical cancer screen in Zhejiang, Sichuan, Beijing, and Inner Mongolia and analyse clinical and population data to identify possible improvements to the screening protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A standard protocol including human papillomavirus (HPV) detection, cytology test, colposcopy, and histopathology inspection was adapted for the screening. Additional HPV genotyping was performed for participants in Sichuan, Beijing, and Inner Mongolia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>12,086 women were included in this study, and 178 cases of cervical intraepithelial neoplasia (CIN) grade 2 or worse (CIN2+) were identified. Detailed analyses on features of age, region, ethnicity, and origin showed a notable correlation between age strata and high-grade CIN rates. Moreover, apart from HPV16\/18, other HPV types such as HPV33, HPV52, and HPV58 were found to be enriched in high-grade CIN cases, as was repeat positivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results suggest that age, HPV16, and ThinPrep cytologic test (TCT) are prominent exploratory predictors for CIN2+ detection, and HPV33, 52, and 58 may pose higher risks than other non-HPV16\/18 types. Future studies incorporating prospective effectiveness and health-economic evaluation are required to validate the clinical utility of these predictors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1920297","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T04:28:53Z","timestamp":1790569733000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A multi-centre study on cervical cancer screening reveals population-related impact on cervical intraepithelial neoplasia rate"],"prefix":"10.3389","volume":"16","author":[{"given":"Yun","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Peking University People\u2019s Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, The First Affiliated Hospital Zhejiang University School of Medicine","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutie","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Cancer Center, West China Second University Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Peking University People\u2019s Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Women\u2019s Hospital, School of Medicine Zhejiang University","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingli","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cancer Center, West China Second University Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Beijing Shijitan Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingran","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Peking University People\u2019s Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Peking University People\u2019s Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiming","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shenzhen Fuyong People's Hospital","place":["Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihui","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Peking University People\u2019s Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"B16","first-page":"1","article-title":"Applications of machine learning algorithms and performance comparison: A review","author":"Abdualgalil","year":"2020"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.3760\/cma.j.cn112137-20230117-00096","article-title":"Chinese expert consensus on the use of human papillomavirus nucleic acid testing for cervical cancer screening (2022)","volume":"103","year":"2023","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"B2","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1097\/cm9.0000000000001474","article-title":"Changing profiles of cancer burden worldwide and in China: A secondary analysis of the global cancer statistics 2020","volume":"134","author":"Cao","year":"2021","journal-title":"Chin. 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