{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:57:58Z","timestamp":1791194278924,"version":"4.1.0"},"reference-count":203,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    Viral entry is the first obligatory step of productive infection and a rational point for host-directed antiviral intervention. This structured narrative review synthesizes evidence from database searches and citation tracking performed up to 18 June 2026. Clathrin-mediated endocytosis (CME) can internalize virus-receptor complexes and deliver them to endosomal compartments that support penetration, fusion, capsid remodeling, uncoating or genome release. However, CME should be interpreted as a series of experimentally separable checkpoints rather than as a single pathway label. Viral use of CME varies with strain, receptor and cofactor availability, host-cell type, membrane composition, protease environment, inoculum size and synchronization conditions. Strict CME-dependent entry is assigned only when direct perturbation of core or proximal CME machinery, supported by rescue or an orthogonal approach, converges with stage-resolved evidence of productive virion progression through clathrin\/AP-2-positive coated pits or vesicles and an early functional entry readout in a defined virus-receptor-cell context. Pharmacological findings are treated as supportive rather than universally mandatory when stronger direct mechanistic evidence is available. The review integrates receptor organization, cargo-specific adaptor recruitment, membrane lipids, particle geometry, actin dynamics and virus-induced remodeling with a transparent evidence framework that distinguishes CME-associated, CME-involved and CME-dependent entry. It further separates mechanistic probes from host-directed strategies targeting membrane sphingolipids, TPC2-dependent endolysosomal trafficking, NPC1\/cholesterol homeostasis, PIKfyve and kinase-regulated trafficking. Translational priorities are framed as context-dependent opportunities requiring target engagement, disease-relevant models and\n                    <jats:italic>in vivo<\/jats:italic>\n                    validation rather than as validated consequences of global CME blockade.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2026.1929024","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:49:26Z","timestamp":1791193766000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Reframing clathrin-mediated viral entry: evidence standards, context dependence and host-directed vulnerabilities"],"prefix":"10.3389","volume":"16","author":[{"given":"Qinying","family":"Wang","sequence":"first","affiliation":[{"name":"Department of The First Clinical Medical College, Henan University of Chinese Medicine","place":["Zhengzhou, China"]},{"name":"Department of AIDS Clinical Research Center, The First Affiliated Hospital of Henan University of Chinese Medicine","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liran","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of The First Clinical Medical College, Henan University of Chinese Medicine","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangang","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Medicine, Henan University of Chinese Medicine","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of The First Clinical Medical College, Henan University of Chinese Medicine","place":["Zhengzhou, China"]},{"name":"Department of AIDS Clinical Research Center, The First Affiliated Hospital of Henan University of Chinese Medicine","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of AIDS Clinical Research Center, The First Affiliated Hospital of Henan University of Chinese Medicine","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"5496","DOI":"10.1128\/JVI.67.9.5496-5501.1993","article-title":"Sindbis virus membrane fusion is mediated by reduction of glycoprotein disulfide bridges at the cell surface","volume":"67","author":"Abell","year":"1993","journal-title":"J. Virol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1111\/j.1462-5822.2009.01345.x","article-title":"Alternative infectious entry pathways for dengue virus serotypes into mammalian cells","volume":"11","author":"Acosta","year":"2009","journal-title":"Cell. Microbiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1093\/jmcb\/mjab016","article-title":"What makes (hydroxy)chloroquine ineffective against COVID-19: insights from cell biology","volume":"13","author":"Altulea","year":"2021","journal-title":"J. Mol. Cell Biol."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/biom14101232","article-title":"Human coronavirus 229E uses clathrin-mediated endocytosis as a route of entry in Huh-7 cells","volume":"14","author":"Andreu","year":"2024","journal-title":"Biomolecules"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2588","DOI":"10.1091\/mbc.E11-04-0362","article-title":"Phosphatidylinositol-(4,5)-bisphosphate regulates clathrin-coated pit initiation, stabilization, and size","volume":"22","author":"Antonescu","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.15252\/embj.201694613","article-title":"Membrane fission by dynamin: what we know and what we need to know","volume":"35","author":"Antonny","year":"2016","journal-title":"EMBO J."},{"key":"B7","doi-asserted-by":"publisher","first-page":"13490","DOI":"10.1128\/JVI.02252-13","article-title":"5-HT2 receptors facilitate JC polyomavirus entry","volume":"87","author":"Assetta","year":"2013","journal-title":"J. Virol."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.00612","article-title":"Depletion of host and viral sphingomyelin impairs influenza virus infection","volume":"11","author":"Audi","year":"2020","journal-title":"Front. Microbiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"12022","DOI":"10.1074\/jbc.M211966200","article-title":"Tyrphostin A23 inhibits internalization of the transferrin receptor by perturbing the interaction between tyrosine motifs and the medium chain subunit of the AP-2 adaptor complex","volume":"278","author":"Banbury","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B10","doi-asserted-by":"publisher","first-page":"28563","DOI":"10.1016\/S0021-9258(19)61942-3","article-title":"ATPase activity associated with the uncoating of clathrin baskets by Hsp70","volume":"269","author":"Barouch","year":"1994","journal-title":"J. Biol. Chem."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-10-177","article-title":"Multiscale perspectives of virus entry via endocytosis","volume":"10","author":"Barrow","year":"2013","journal-title":"Virol. J."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/j.cell.2008.11.028","article-title":"GTPase cycle of dynamin is coupled to membrane squeeze and release, leading to spontaneous fission","volume":"135","author":"Bashkirov","year":"2008","journal-title":"Cell."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100306","article-title":"SARS-CoV-2 infects cells after viral entry via clathrin-mediated endocytosis","volume":"296","author":"Bayati","year":"2021","journal-title":"J. Biol. Chem."},{"key":"B14","doi-asserted-by":"publisher","first-page":"3952","DOI":"10.1074\/jbc.M004722200","article-title":"Inhibition of clathrin-dependent endocytosis has multiple effects on human rhinovirus serotype 2 cell entry","volume":"276","author":"Bayer","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1242\/jcs.112.9.1303","article-title":"Inhibition of clathrin-coated pit assembly by an Eps15 mutant","volume":"112","author":"Benmerah","year":"1999","journal-title":"J. Cell Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1126\/science.275.5304.1320","article-title":"Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5","volume":"275","author":"Bergelson","year":"1997","journal-title":"Science"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011479","article-title":"Endocytosis of chikungunya virus into mammalian cells: role of clathrin and early endosomal compartments","volume":"5","author":"Bernard","year":"2010","journal-title":"PLoS One"},{"key":"B18","doi-asserted-by":"publisher","first-page":"6150","DOI":"10.1128\/JVI.03372-12","article-title":"TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium","volume":"87","author":"Bertram","year":"2013","journal-title":"J. Virol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1091\/mbc.E20-06-0363","article-title":"Early and nonredundant functions of dynamin isoforms in clathrin-mediated endocytosis","volume":"31","author":"Bhave","year":"2020","journal-title":"Mol. Biol. Cell"},{"key":"B20","doi-asserted-by":"publisher","first-page":"6964","DOI":"10.1128\/JVI.00024-06","article-title":"Hepatitis C virus entry depends on clathrin-mediated endocytosis","volume":"80","author":"Blanchard","year":"2006","journal-title":"J. Virol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.cell.2012.01.047","article-title":"Membrane fission is promoted by insertion of amphipathic helices and is restricted by crescent BAR domains","volume":"149","author":"Boucrot","year":"2012","journal-title":"Cell."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1038\/ncb2307","article-title":"Actin dynamics counteract membrane tension during clathrin-mediated endocytosis","volume":"13","author":"Boulant","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"3770","DOI":"10.1128\/JVI.00265-08","article-title":"Site of human rhinovirus RNA uncoating revealed by fluorescent in situ hybridization","volume":"83","author":"Brabec-Zaruba","year":"2009","journal-title":"J. Virol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nrmicro1615","article-title":"Virus trafficking - learning from single-virus tracking","volume":"5","author":"Brandenburg","year":"2007","journal-title":"Nat. Rev. Microbiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"3846","DOI":"10.1038\/s41467-025-58935-8","article-title":"Single influenza A viruses induce nanoscale cellular reprogramming at the virus-cell interface","volume":"16","author":"Broich","year":"2025","journal-title":"Nat. Commun."},{"key":"B26","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1016\/j.cell.2023.03.032","article-title":"Structure of Semliki Forest virus in complex with its receptor VLDLR","volume":"186","author":"Cao","year":"2023","journal-title":"Cell."},{"key":"B27","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/nature10348","article-title":"Ebola virus entry requires the cholesterol transporter Niemann-Pick C1","volume":"477","author":"Carette","year":"2011","journal-title":"Nature"},{"key":"B28","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1002\/jcp.1041380311","article-title":"Potassium depletion and hypertonic medium reduce \u201cnon-coated\u201d and clathrin-coated pit formation, as well as endocytosis through these two gates","volume":"138","author":"Carpentier","year":"1989","journal-title":"J. Cell. Physiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.cell.2011.09.003","article-title":"A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke","volume":"147","author":"Chappie","year":"2011","journal-title":"Cell."},{"key":"B30","doi-asserted-by":"publisher","first-page":"11790","DOI":"10.1073\/pnas.0803711105","article-title":"Epsin 1 is a cargo-specific adaptor for the clathrin-mediated endocytosis of the influenza virus","volume":"105","author":"Chen","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B31","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1080\/22221751.2019.1618686","article-title":"Endophilin-A2-mediated endocytic pathway is critical for enterovirus 71 entry into caco-2 cells","volume":"8","author":"Chen","year":"2019","journal-title":"Emerg. Microbes Infect."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201908189","article-title":"Wbox2: A clathrin terminal domain-derived peptide inhibitor of clathrin-mediated endocytosis","volume":"219","author":"Chen","year":"2020","journal-title":"J. Cell Biol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"10543","DOI":"10.1128\/JVI.78.19.10543-10555.2004","article-title":"Infectious entry of West Nile virus occurs through a clathrin-mediated endocytic pathway","volume":"78","author":"Chu","year":"2004","journal-title":"J. Virol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"54533","DOI":"10.1074\/jbc.M410208200","article-title":"Interaction of West Nile virus with alpha v beta 3 integrin mediates virus entry into cells","volume":"279","author":"Chu","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B35","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/s41586-021-04326-0","article-title":"VLDLR and ApoER2 are receptors for multiple alphaviruses","volume":"602","author":"Clark","year":"2022","journal-title":"Nature"},{"key":"B36","doi-asserted-by":"publisher","first-page":"10406","DOI":"10.1128\/JVI.00990-09","article-title":"Cell entry of Borna disease virus follows a clathrin-mediated endocytosis pathway that requires Rab5 and microtubules","volume":"83","author":"Clemente","year":"2009","journal-title":"J. Virol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.cell.2012.05.047","article-title":"The first five seconds in the life of a clathrin-coated pit","volume":"150","author":"Cocucci","year":"2012","journal-title":"Cell."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12020171","article-title":"Nanomaterials designed for antiviral drug delivery transport across biological barriers","volume":"12","author":"Cojocaru","year":"2020","journal-title":"Pharmaceutics"},{"key":"B39","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/nature01451","article-title":"Regulated portals of entry into the cell","volume":"422","author":"Conner","year":"2003","journal-title":"Nature"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016972","article-title":"Endocytosis of viruses and bacteria","volume":"6","author":"Cossart","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1083\/jcb.108.2.377","article-title":"Low cytoplasmic pH inhibits endocytosis and transport from the trans-Golgi network to the cell surface","volume":"108","author":"Cosson","year":"1989","journal-title":"J. Cell Biol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1093\/femsre\/fuu004","article-title":"Receptors and routes of dengue virus entry into the host cells","volume":"39","author":"Cruz-Oliveira","year":"2015","journal-title":"FEMS Microbiol. Rev."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000394","article-title":"Vesicular stomatitis virus enters cells through vesicles incompletely coated with clathrin that depend upon actin for internalization","volume":"5","author":"Cureton","year":"2009","journal-title":"PLoS Pathog."},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001127","article-title":"The length of vesicular stomatitis virus particles dictates a need for actin assembly during clathrin-dependent endocytosis","volume":"6","author":"Cureton","year":"2010","journal-title":"PLoS Pathog."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1128\/JVI.79.3.1581-1594.2005","article-title":"Involvement of clathrin-mediated endocytosis in human immunodeficiency virus type 1 entry","volume":"79","author":"Daecke","year":"2005","journal-title":"J. Virol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1111\/tra.12272","article-title":"Phenothiazine-derived antipsychotic drugs inhibit dynamin and clathrin-mediated endocytosis","volume":"16","author":"Daniel","year":"2015","journal-title":"Traffic Cph. Den."},{"key":"B47","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.jsb.2004.04.005","article-title":"Rapid constriction of lipid bilayers by the mechanochemical enzyme dynamin","volume":"147","author":"Danino","year":"2004","journal-title":"J. Struct. Biol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1128\/JVI.80.3.1290-1301.2006","article-title":"West Nile virus discriminates between DC-SIGN and DC-SIGNR for cellular attachment and infection","volume":"80","author":"Davis","year":"2006","journal-title":"J. Virol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/nature06828","article-title":"Clathrin is a key regulator of basolateral polarity","volume":"452","author":"Deborde","year":"2008","journal-title":"Nature"},{"key":"B50","doi-asserted-by":"publisher","first-page":"4585","DOI":"10.1093\/emboj\/17.16.4585","article-title":"The clathrin endocytic pathway in viral infection","volume":"17","author":"DeTulleo","year":"1998","journal-title":"EMBO J."},{"key":"B51","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/nbt.3437","article-title":"Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9","volume":"34","author":"Doench","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"23090","DOI":"10.1021\/acsnano.4c05261","article-title":"Revealing different pathways for influenza A virus to reach microtubules after endocytosis by quantum dot-based single-virus tracking","volume":"18","author":"Du","year":"2024","journal-title":"ACS Nano"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045799","article-title":"Pitstop 2 is a potent inhibitor of clathrin-independent endocytosis","volume":"7","author":"Dutta","year":"2012","journal-title":"PLoS One"},{"key":"B54","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.cell.2004.08.017","article-title":"Endocytosis by random initiation and stabilization of clathrin-coated pits","volume":"118","author":"Ehrlich","year":"2004","journal-title":"Cell."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1111\/tra.12425","article-title":"Ikarugamycin: a natural product inhibitor of clathrin-mediated endocytosis","volume":"17","author":"Elkin","year":"2016","journal-title":"Traffic Cph. Den."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1126\/science.1103492","article-title":"The human polyomavirus, JCV, uses serotonin receptors to infect cells","volume":"306","author":"Elphick","year":"2004","journal-title":"Science"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01557-22","article-title":"Colocalization of Chikungunya virus with its receptor MXRA8 during cell attachment, internalization, and membrane fusion","volume":"97","author":"Feng","year":"2023","journal-title":"J. Virol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/nrm3266","article-title":"Dynamin, a membrane-remodelling GTPase","volume":"13","author":"Ferguson","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"7306","DOI":"10.1073\/pnas.1214441110","article-title":"LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus","volume":"110","author":"Finkelshtein","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B60","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/nature01020","article-title":"Curvature of clathrin-coated pits driven by epsin","volume":"419","author":"Ford","year":"2002","journal-title":"Nature"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1126\/science.291.5506.1051","article-title":"Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes","volume":"291","author":"Ford","year":"2001","journal-title":"Science"},{"key":"B62","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/nature03078","article-title":"Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating","volume":"432","author":"Fotin","year":"2004","journal-title":"Nature"},{"key":"B63","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/nature03079","article-title":"Molecular model for a complete clathrin lattice from electron cryomicroscopy","volume":"432","author":"Fotin","year":"2004","journal-title":"Nature"},{"key":"B64","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.virol.2013.05.030","article-title":"Crimean-Congo hemorrhagic fever virus utilizes a clathrin- and early endosome-dependent entry pathway","volume":"444","author":"Garrison","year":"2013","journal-title":"Virology"},{"key":"B65","doi-asserted-by":"publisher","first-page":"3951","DOI":"10.1128\/JVI.73.5.3951-3959.1999","article-title":"Cellular entry of hantaviruses which cause hemorrhagic fever with renal syndrome is mediated by beta3 integrins","volume":"73","author":"Gavrilovskaya","year":"1999","journal-title":"J. Virol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.cell.2014.09.029","article-title":"Genome-scale CRISPR-mediated control of gene repression and activation","volume":"159","author":"Gilbert","year":"2014","journal-title":"Cell."},{"key":"B67","doi-asserted-by":"publisher","first-page":"E4904","DOI":"10.1073\/pnas.1302334110","article-title":"Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses","volume":"110","author":"Gillespie","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B68","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1006\/viro.1998.9275","article-title":"The role of low pH and disulfide shuffling in the entry and fusion of Semliki Forest virus and Sindbis virus","volume":"248","author":"Glomb-Reinmund","year":"1998","journal-title":"Virology"},{"key":"B69","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1128\/JVI.01802-12","article-title":"Macropinocytosis-like HIV-1 internalization in macrophages is CCR5 dependent and leads to efficient but delayed degradation in endosomal compartments","volume":"87","author":"Gobeil","year":"2013","journal-title":"J. Virol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1083\/jcb.201108131","article-title":"The cell biology of receptor-mediated virus entry","volume":"195","author":"Grove","year":"2011","journal-title":"J. Cell Biol."},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.29730","article-title":"Guanylate-binding protein 1 inhibits Hantaan virus infection by restricting virus entry","volume":"96","author":"Gu","year":"2024","journal-title":"J. Med. Virol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/jmi.13056","article-title":"Correlative light and volume electron microscopy (vCLEM): how community participation can advance developing technologies","volume":"284","author":"Guerin","year":"2021","journal-title":"J. Microsc."},{"key":"B73","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/0014-5793(94)00695-4","article-title":"Concanamycin A blocks influenza virus entry into cells under acidic conditions","volume":"349","author":"Guinea","year":"1994","journal-title":"FEBS Lett."},{"key":"B74","doi-asserted-by":"publisher","first-page":"8880","DOI":"10.1128\/JVI.00354-15","article-title":"Biology of Zika virus infection in human skin cells","volume":"89","author":"Hamel","year":"2015","journal-title":"J. Virol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1083\/jcb.121.1.61","article-title":"Clathrin and HA2 adaptors: effects of potassium depletion, hypertonic medium, and cytosol acidification","volume":"121","author":"Hansen","year":"1993","journal-title":"J. Cell Biol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.celrep.2017.03.058","article-title":"TAM receptors are not required for Zika virus infection in mice","volume":"19","author":"Hastings","year":"2017","journal-title":"Cell Rep."},{"key":"B77","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1083\/jcb.84.2.404","article-title":"On the entry of Semliki Forest virus into BHK-21 cells","volume":"84","author":"Helenius","year":"1980","journal-title":"J. Cell Biol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1007\/s00018-007-7291-8","article-title":"Hepatitis C virus entry into host cells","volume":"65","author":"Helle","year":"2008","journal-title":"Cell. Mol. Life. Sci. CMLS"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1126\/science.1188462","article-title":"FCHo proteins are nucleators of clathrin-mediated endocytosis","volume":"328","author":"Henne","year":"2010","journal-title":"Science"},{"key":"B80","doi-asserted-by":"publisher","first-page":"13956","DOI":"10.1128\/JVI.01543-14","article-title":"HIV-1 entry in SupT1-R5, CEM-ss, and primary CD4+ T cells occurs at the plasma membrane and does not require endocytosis","volume":"88","author":"Herold","year":"2014","journal-title":"J. Virol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"6910","DOI":"10.1038\/s41598-017-07023-z","article-title":"Blockade of dengue virus infection and viral cytotoxicity in neuronal cells in vitro and in vivo by targeting endocytic pathways","volume":"7","author":"Ho","year":"2017","journal-title":"Sci. Rep."},{"key":"B82","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell."},{"key":"B83","doi-asserted-by":"publisher","first-page":"4745","DOI":"10.1128\/JVI.03184-15","article-title":"Dynamics of Chikungunya virus cell entry unraveled by single-virus tracking in living cells","volume":"90","author":"Hoornweg","year":"2016","journal-title":"J. Virol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"16657","DOI":"10.1074\/jbc.C400046200","article-title":"Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference","volume":"279","author":"Huang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B85","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1074\/jbc.M110.168468","article-title":"The essential role of clathrin-mediated endocytosis in the infectious entry of human enterovirus 71","volume":"286","author":"Hussain","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B86","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1002\/hep.29785","article-title":"Cellular membrane trafficking machineries used by the hepatitis viruses","volume":"68","author":"Inoue","year":"2018","journal-title":"Hepatology"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114989","article-title":"Intersectin1 promotes clathrin-mediated endocytosis by organizing and stabilizing endocytic protein interaction networks","volume":"43","author":"Jin","year":"2024","journal-title":"Cell Rep."},{"key":"B88","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1006\/viro.2001.1303","article-title":"Hantaan virus enters cells by clathrin-dependent receptor-mediated endocytosis","volume":"294","author":"Jin","year":"2002","journal-title":"Virology"},{"key":"B89","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1128\/JVI.01864-08","article-title":"Host cell factors and functions involved in vesicular stomatitis virus entry","volume":"83","author":"Johannsdottir","year":"2009","journal-title":"J. Virol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nrm.2017.132","article-title":"Mechanisms of clathrin-mediated endocytosis","volume":"19","author":"Kaksonen","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1007\/s00726-009-0363-3","article-title":"Virus entry paradigms","volume":"41","author":"Kalia","year":"2011","journal-title":"Amino Acids"},{"key":"B92","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1128\/JVI.01399-12","article-title":"Japanese encephalitis virus infects neuronal cells through a clathrin-independent endocytic mechanism","volume":"87","author":"Kalia","year":"2013","journal-title":"J. Virol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"20803","DOI":"10.1073\/pnas.2007837117","article-title":"Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2","volume":"117","author":"Kang","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B94","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1128\/JVI.01933-08","article-title":"Protease-mediated entry via the endosome of human coronavirus 229E","volume":"83","author":"Kawase","year":"2009","journal-title":"J. Virol."},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021107821","article-title":"TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cells","volume":"40","author":"Koch","year":"2021","journal-title":"EMBO J."},{"key":"B96","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1038\/s41467-021-22380-0","article-title":"Reovirus directly engages integrin to recruit clathrin for entry into host cells","volume":"12","author":"Koehler","year":"2021","journal-title":"Nat. Commun."},{"key":"B97","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1038\/nmeth.1395","article-title":"High-speed nanoscopic tracking of the position and orientation of a single virus","volume":"6","author":"Kukura","year":"2009","journal-title":"Nat. Methods"},{"key":"B98","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1080\/22221751.2021.2020598","article-title":"Pharmacologically induced endolysosomal cholesterol imbalance through clinically licensed drugs itraconazole and fluoxetine impairs Ebola virus infection in vitro","volume":"11","author":"Kummer","year":"2022","journal-title":"Emerg. Microbes Infect."},{"key":"B99","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1080\/13550280590900427","article-title":"Rabies virus receptors","volume":"11","author":"Lafon","year":"2005","journal-title":"J. Neurovirol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"9280","DOI":"10.1073\/pnas.0832269100","article-title":"Visualizing infection of individual influenza viruses","volume":"100","author":"Lakadamyali","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B101","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/ncb1269","article-title":"Endosome-to-cytosol transport of viral nucleocapsids","volume":"7","author":"Le Blanc","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007610","article-title":"Macropinocytosis dependent entry of Chikungunya virus into human muscle cells","volume":"13","author":"Lee","year":"2019","journal-title":"PLoS Negl.Trop. Dis."},{"key":"B103","doi-asserted-by":"publisher","first-page":"3890","DOI":"10.1021\/acsnano.7b00275","article-title":"Single-particle tracking of human immunodeficiency virus type 1 productive entry into human primary macrophages","volume":"11","author":"Li","year":"2017","journal-title":"ACS Nano"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab3500","article-title":"Advanced imaging. Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics","volume":"349","author":"Li","year":"2015","journal-title":"Science"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.00242","article-title":"Characterization of Zika virus endocytic pathways in human glioblastoma cells","volume":"11","author":"Li","year":"2020","journal-title":"Front. Microbiol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"9064","DOI":"10.1128\/JVI.00573-13","article-title":"Caveolar endocytosis is required for human PSGL-1-mediated enterovirus 71 infection","volume":"87","author":"Lin","year":"2013","journal-title":"J. Virol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1083\/jcb.201008117","article-title":"Local clustering of transferrin receptors promotes clathrin-coated pit initiation","volume":"191","author":"Liu","year":"2010","journal-title":"J. Cell Biol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1021\/acs.chemrev.9b00692","article-title":"Single-virus tracking: From imaging methodologies to virological applications","volume":"120","author":"Liu","year":"2020","journal-title":"Chem. Rev."},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01113-17","article-title":"Rab5 and Rab11 are required for clathrin-dependent endocytosis of Japanese encephalitis virus in BHK-21 cells","volume":"91","author":"Liu","year":"2017","journal-title":"J. Virol."},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000057","article-title":"Cargo and dynamin regulate clathrin-coated pit maturation","volume":"7","author":"Loerke","year":"2009","journal-title":"PLoS Biol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/s41580-018-0094-y","article-title":"Spatial proteomics: a powerful discovery tool for cell biology","volume":"20","author":"Lundberg","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2024.199394","article-title":"T-cell immunoglobulin and mucin 1 (TIM-1) mediates infection of Hantaan virus in Jurkat T cells","volume":"346","author":"Ma","year":"2024","journal-title":"Virus Res."},{"key":"B113","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.devcel.2006.04.002","article-title":"Dynasore, a cell-permeable inhibitor of dynamin","volume":"10","author":"Macia","year":"2006","journal-title":"Dev. Cell"},{"key":"B114","doi-asserted-by":"publisher","first-page":"2590","DOI":"10.1016\/j.jmb.2018.06.024","article-title":"Virus-receptor interactions: The key to cellular invasion","volume":"430","author":"Maginnis","year":"2018","journal-title":"J. Mol. Biol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"3181","DOI":"10.1128\/JVI.01612-07","article-title":"NPXY motifs in the beta1 integrin cytoplasmic tail are required for functional reovirus entry","volume":"82","author":"Maginnis","year":"2008","journal-title":"J. Virol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1039\/c0mb00126k","article-title":"Chemical proteomics reveals bolinaquinone as a clathrin-mediated endocytosis inhibitor","volume":"7","author":"Margarucci","year":"2011","journal-title":"Mol. Biosyst."},{"key":"B117","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/0092-8674(83)90078-8","article-title":"Penetration of Semliki Forest virus from acidic prelysosomal vacuoles","volume":"32","author":"Marsh","year":"1983","journal-title":"Cell."},{"key":"B118","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1083\/jcb.91.3.601","article-title":"Infectious entry pathway of influenza virus in a canine kidney cell line","volume":"91","author":"Matlin","year":"1981","journal-title":"J. Cell Biol."},{"key":"B119","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/0022-2836(82)90269-8","article-title":"Pathway of vesicular stomatitis virus entry leading to infection","volume":"156","author":"Matlin","year":"1982","journal-title":"J. Mol. Biol."},{"key":"B120","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/nature14509","article-title":"A hemi-fission intermediate links two mechanistically distinct stages of membrane fission","volume":"524","author":"Mattila","year":"2015","journal-title":"Nature"},{"key":"B121","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1080\/15548627.2018.1474314","article-title":"Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion","volume":"14","author":"Mauthe","year":"2018","journal-title":"Autophagy"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01948-18","article-title":"JC polyomavirus entry by clathrin-mediated endocytosis is driven by \u03b2-arrestin","volume":"93","author":"Mayberry","year":"2019","journal-title":"J. Virol."},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016758","article-title":"Clathrin-independent pathways of endocytosis","volume":"6","author":"Mayor","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/nrm3151","article-title":"Molecular mechanism and physiological functions of clathrin-mediated endocytosis","volume":"12","author":"McMahon","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/379353a0","article-title":"A presynaptic inositol-5-phosphatase","volume":"379","author":"McPherson","year":"1996","journal-title":"Nature"},{"key":"B126","doi-asserted-by":"publisher","first-page":"11571","DOI":"10.1128\/JVI.01717-06","article-title":"Hepatitis C virus entry requires a critical postinternalization step and delivery to early endosomes via clathrin-coated vesicles","volume":"80","author":"Meertens","year":"2006","journal-title":"J. Virol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.celrep.2016.12.045","article-title":"Axl mediates ZIKA virus entry in human glial cells and modulates innate immune responses","volume":"18","author":"Meertens","year":"2017","journal-title":"Cell Rep."},{"key":"B128","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1083\/jcb.200112067","article-title":"Adenovirus triggers macropinocytosis and endosomal leakage together with its clathrin-mediated uptake","volume":"158","author":"Meier","year":"2002","journal-title":"J. Cell Biol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1146\/annurev-biochem-060208-104626","article-title":"Virus entry by endocytosis","volume":"79","author":"Mercer","year":"2010","journal-title":"Annu. Rev. Biochem."},{"key":"B130","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1146\/annurev-biochem-062917-012644","article-title":"Regulation of clathrin-mediated endocytosis","volume":"87","author":"Mettlen","year":"2018","journal-title":"Annu. Rev. Biochem."},{"key":"B131","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.cell.2009.02.046","article-title":"HIV enters cells via endocytosis and dynamin-dependent fusion with endosomes","volume":"137","author":"Miyauchi","year":"2009","journal-title":"Cell."},{"key":"B132","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1083\/jcb.200305145","article-title":"Clathrin-mediated endocytosis in AP-2-depleted cells","volume":"162","author":"Motley","year":"2003","journal-title":"J. Cell Biol."},{"key":"B133","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.bbrc.2005.11.049","article-title":"Cellular entry of Hantaan virus A9 strain: specific interactions with beta3 integrins and a novel 70kDa protein","volume":"339","author":"Mou","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B134","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1126\/science.1127085","article-title":"Proteasome-independent functions of ubiquitin in endocytosis and signaling","volume":"315","author":"Mukhopadhyay","year":"2007","journal-title":"Science"},{"key":"B135","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1099\/vir.0.18883-0","article-title":"Interference in Japanese encephalitis virus infection of Vero cells by a cationic amphiphilic drug, chlorpromazine","volume":"84","author":"Nawa","year":"2003","journal-title":"J. Gen. Virol."},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005540","article-title":"The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection","volume":"11","author":"Nelson","year":"2017","journal-title":"PLoS Negl.Trop. Dis."},{"key":"B137","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.chom.2010.09.004","article-title":"Structure-function analysis of the human JC polyomavirus establishes the LSTc pentasaccharide as a functional receptor motif","volume":"8","author":"Neu","year":"2010","journal-title":"Cell Host Microbe"},{"key":"B138","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1038\/s41564-024-01713-x","article-title":"Influenza virus uses mGluR2 as an endocytic receptor to enter cells","volume":"9","author":"Ni","year":"2024","journal-title":"Nat. Microbiol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1111\/j.1600-0854.2011.01273.x","article-title":"Hotspots organize clathrin-mediated endocytosis by efficient recruitment and retention of nucleating resources","volume":"12","author":"Nunez","year":"2011","journal-title":"Traffic Cph. Den."},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009212","article-title":"Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2","volume":"17","author":"Ou","year":"2021","journal-title":"PLoS Pathog."},{"key":"B141","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12964-019-0349-z","article-title":"Zika virus: mapping and reprogramming the entry","volume":"17","author":"Owczarek","year":"2019","journal-title":"Cell. Commun. Signal. CCS"},{"key":"B142","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1139\/w08-107","article-title":"Entry of dengue virus serotype 2 into ECV304 cells depends on clathrin-dependent endocytosis, but not on caveolae-dependent endocytosis","volume":"55","author":"Peng","year":"2009","journal-title":"Can. J. Microbiol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.virol.2018.03.009","article-title":"Infection by Zika viruses requires the transmembrane protein AXL, endocytosis and low pH","volume":"518","author":"Persaud","year":"2018","journal-title":"Virology"},{"key":"B144","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.1128\/jvi.74.5.2288-2292.2000","article-title":"JC virus enters human glial cells by clathrin-dependent receptor-mediated endocytosis","volume":"74","author":"Pho","year":"2000","journal-title":"J. Virol."},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140824","article-title":"Dengue-3 virus entry into Vero cells: Role of clathrin-mediated endocytosis in the outcome of infection","volume":"10","author":"Piccini","year":"2015","journal-title":"PLoS One"},{"key":"B146","doi-asserted-by":"publisher","first-page":"11637","DOI":"10.1128\/JVI.01648-13","article-title":"Uptake of rabies virus into epithelial cells by clathrin-mediated endocytosis depends upon actin","volume":"87","author":"Piccinotti","year":"2013","journal-title":"J. Virol."},{"key":"B147","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.copbio.2009.03.008","article-title":"Correlative cryo-light microscopy and cryo-electron tomography: from cellular territories to molecular landscapes","volume":"20","author":"Plitzko","year":"2009","journal-title":"Curr. Opin. Biotechnol."},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2026.119738","article-title":"Acid sphingomyelinase is an age-dependent host cell factor for adenovirus entry and a pharmacological target for synergistic combination therapy with brincidofovir","volume":"201","author":"Post","year":"2026","journal-title":"Biomed. Pharmacother. Biomedecine Pharmacother."},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202400253","article-title":"Inhibition clathrin mediated endocytosis: Pitstop 1\u2009and Pitstop 2 chimeras","volume":"19","author":"Prichard","year":"2024","journal-title":"ChemMedChem"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.754110","article-title":"Role of clathrin and dynamin in clathrin mediated endocytosis\/synaptic vesicle recycling and implications in neurological diseases","volume":"15","author":"Prichard","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"B151","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/j.cell.2008.11.020","article-title":"Real-time visualization of dynamin-catalyzed membrane fission and vesicle release","volume":"135","author":"Pucadyil","year":"2008","journal-title":"Cell."},{"key":"B152","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1128\/jvi.78.1.250-256.2004","article-title":"A JC virus-induced signal is required for infection of glial cells by a clathrin- and eps15-dependent pathway","volume":"78","author":"Querbes","year":"2004","journal-title":"J. Virol."},{"key":"B153","doi-asserted-by":"publisher","first-page":"9402","DOI":"10.1128\/JVI.01086-06","article-title":"Invasion of host cells by JC virus identifies a novel role for caveolae in endosomal sorting of noncaveolar ligands","volume":"80","author":"Querbes","year":"2006","journal-title":"J. Virol."},{"key":"B154","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41565-021-00858-8","article-title":"Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics","volume":"16","author":"Rennick","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"B155","doi-asserted-by":"publisher","first-page":"e30","DOI":"10.1016\/S0140-6736(20)30304-4","article-title":"Baricitinib as potential treatment for 2019-nCoV acute respiratory disease","volume":"395","author":"Richardson","year":"2020","journal-title":"Lancet"},{"key":"B156","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/s41586-020-2577-1","article-title":"Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing","volume":"586","author":"Riva","year":"2020","journal-title":"Nature"},{"key":"B157","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.tcb.2004.02.002","article-title":"Adaptable adaptors for coated vesicles","volume":"14","author":"Robinson","year":"2004","journal-title":"Trends Cell Biol."},{"key":"B158","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/nsmb769","article-title":"Assembly of endocytic machinery around individual influenza viruses during viral entry","volume":"11","author":"Rust","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B159","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1126\/science.1258758","article-title":"Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment","volume":"347","author":"Sakurai","year":"2015","journal-title":"Science"},{"key":"B160","doi-asserted-by":"publisher","first-page":"5416","DOI":"10.1038\/s41467-018-07901-8","article-title":"Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities","volume":"9","author":"Sanson","year":"2018","journal-title":"Nat. Commun."},{"key":"B161","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1080\/22221751.2020.1829082","article-title":"Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine","volume":"9","author":"Schloer","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"B162","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1038\/nature06031","article-title":"Integrating molecular and network biology to decode endocytosis","volume":"448","author":"Schmid","year":"2007","journal-title":"Nature"},{"key":"B163","doi-asserted-by":"publisher","first-page":"12665","DOI":"10.1128\/JVI.01861-12","article-title":"Reovirus uses multiple endocytic pathways for cell entry","volume":"86","author":"Schulz","year":"2012","journal-title":"J. Virol."},{"key":"B164","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.virol.2017.11.012","article-title":"Wild-type human coronaviruses prefer cell-surface TMPRSS2 to endosomal cathepsins for cell entry","volume":"517","author":"Shirato","year":"2018","journal-title":"Virology"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004390","article-title":"Crimean-Congo hemorrhagic fever virus entry into host cells occurs through the multivesicular body and requires ESCRT regulators","volume":"10","author":"Shtanko","year":"2014","journal-title":"PLoS Pathog."},{"key":"B166","doi-asserted-by":"publisher","first-page":"10455","DOI":"10.1128\/jvi.76.20.10455-10464.2002","article-title":"Influenza virus can enter and infect cells in the absence of clathrin-mediated endocytosis","volume":"76","author":"Sieczkarski","year":"2002","journal-title":"J. Virol."},{"key":"B167","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1099\/vir.0.006387-0","article-title":"Crimean-Congo hemorrhagic fever virus entry and replication is clathrin-, pH- and cholesterol-dependent","volume":"90","author":"Simon","year":"2009","journal-title":"J. Gen. Virol."},{"key":"B168","doi-asserted-by":"publisher","first-page":"8476","DOI":"10.1128\/JVI.73.10.8476-8484.1999","article-title":"Low-pH-dependent fusion of Sindbis virus with receptor-free cholesterol- and sphingolipid-containing liposomes","volume":"73","author":"Smit","year":"1999","journal-title":"J. Virol."},{"key":"B169","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1126\/science.1094823","article-title":"How viruses enter animal cells","volume":"304","author":"Smith","year":"2004","journal-title":"Science"},{"key":"B170","doi-asserted-by":"publisher","first-page":"5360","DOI":"10.1128\/jvi.77.9.5360-5369.2003","article-title":"Human rhinovirus type 2 is internalized by clathrin-mediated endocytosis","volume":"77","author":"Snyers","year":"2003","journal-title":"J. Virol."},{"key":"B171","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1038\/nsmb.3272","article-title":"Clathrin-coat disassembly illuminates the mechanisms of Hsp70 force generation","volume":"23","author":"Sousa","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B172","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.celrep.2014.12.054","article-title":"Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein","volume":"10","author":"Strating","year":"2015","journal-title":"Cell Rep."},{"key":"B173","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.4161\/auto.26448","article-title":"HSPA8\/HSC70 chaperone protein: structure, function, and chemical targeting","volume":"9","author":"Stricher","year":"2013","journal-title":"Autophagy"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-16-17","article-title":"Characterization of dengue virus entry into HepG2 cells","volume":"16","author":"Suksanpaisan","year":"2009","journal-title":"J. Biomed. Sci."},{"key":"B175","doi-asserted-by":"publisher","first-page":"4395","DOI":"10.1021\/acsnano.6b07853","article-title":"Real-time dissection of distinct dynamin-dependent endocytic routes of influenza A virus by quantum dot-based single-virus tracking","volume":"11","author":"Sun","year":"2017","journal-title":"ACS Nano"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00638-25","article-title":"Rabies virus utilizes neuropilin 2 as an endocytic receptor to trigger TGFBR1-mediated actin polymerization","volume":"99","author":"Sun","year":"2025","journal-title":"J. Virol."},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000604","article-title":"A high precision survey of the molecular dynamics of mammalian clathrin-mediated endocytosis","volume":"9","author":"Taylor","year":"2011","journal-title":"PLoS Biol."},{"key":"B178","doi-asserted-by":"publisher","first-page":"28727","DOI":"10.1074\/jbc.271.46.28727","article-title":"Eps15 is a component of clathrin-coated pits and vesicles and is located at the rim of coated pits","volume":"271","author":"Tebar","year":"1996","journal-title":"J. Biol. Chem."},{"key":"B179","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/nrm2751","article-title":"Tickets to ride: selecting cargo for clathrin-regulated internalization","volume":"10","author":"Traub","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016790","article-title":"Cargo recognition in clathrin-mediated endocytosis","volume":"5","author":"Traub","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B181","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/ncb2473","article-title":"Distinct and separable activities of the endocytic clathrin-coat components Fcho1\/2 and AP-2 in developmental patterning","volume":"14","author":"Umasankar","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"B182","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1083\/jcb.122.3.553","article-title":"Mutations in human dynamin block an intermediate stage in coated vesicle formation","volume":"122","author":"van der Bliek","year":"1993","journal-title":"J. Cell Biol."},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000244","article-title":"Dissecting the cell entry pathway of dengue virus by single-particle tracking in living cells","volume":"4","author":"van der Schaar","year":"2008","journal-title":"PLoS Pathog."},{"key":"B184","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.cell.2011.06.025","article-title":"Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition","volume":"146","author":"von Kleist","year":"2011","journal-title":"Cell."},{"key":"B185","doi-asserted-by":"publisher","first-page":"4980","DOI":"10.1093\/emboj\/cdg511","article-title":"Clathrin self-assembly involves coordinated weak interactions favorable for cellular regulation","volume":"22","author":"Wakeham","year":"2003","journal-title":"EMBO J."},{"key":"B186","doi-asserted-by":"publisher","first-page":"3455","DOI":"10.1128\/JVI.72.4.3455-3458.1998","article-title":"Adenovirus internalization and infection require dynamin","volume":"72","author":"Wang","year":"1998","journal-title":"J. Virol."},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.01577","article-title":"Mechanism and complex roles of HSC70 in viral infections","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Microbiol."},{"key":"B188","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1083\/jcb.123.5.1107","article-title":"Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation","volume":"123","author":"Wang","year":"1993","journal-title":"J. Cell Biol."},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.3390\/v12010045","article-title":"The serine\/threonine kinase AP2-associated kinase 1 plays an important role in rabies virus entry","volume":"12","author":"Wang","year":"2019","journal-title":"Viruses"},{"key":"B190","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1126\/science.1246981","article-title":"Genetic screens in human cells using the CRISPR-Cas9 system","volume":"343","author":"Wang","year":"2014","journal-title":"Science"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01612-22","article-title":"Transferrin receptor protein 1 is an entry factor for rabies virus","volume":"97","author":"Wang","year":"2023","journal-title":"J. Virol."},{"key":"B192","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1038\/nrm970","article-title":"Epsins: adaptors in endocytosis","volume":"3","author":"Wendland","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B193","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/0092-8674(93)90231-e","article-title":"Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment","volume":"73","author":"Wickham","year":"1993","journal-title":"Cell."},{"key":"B194","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1242\/bio.20147955","article-title":"Non-specificity of Pitstop 2 in clathrin-mediated endocytosis","volume":"3","author":"Willox","year":"2014","journal-title":"Biol. Open"},{"key":"B195","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1038\/s41422-023-00917-w","article-title":"LDLR is an entry receptor for Crimean-Congo hemorrhagic fever virus","volume":"34","author":"Xu","year":"2024","journal-title":"Cell Res."},{"key":"B196","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1242\/jcs.119685","article-title":"Virus entry at a glance","volume":"126","author":"Yamauchi","year":"2013","journal-title":"J. Cell Sci."},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1012770","article-title":"Structural insights into Semiliki forest virus receptor binding modes indicate novel mechanism of virus endocytosis","volume":"20","author":"Yang","year":"2024","journal-title":"PLoS Pathog."},{"key":"B198","doi-asserted-by":"publisher","first-page":"17707","DOI":"10.1016\/S0021-9258(19)47429-2","article-title":"Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells","volume":"266","author":"Yoshimori","year":"1991","journal-title":"J. Biol. Chem."},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens7030068","article-title":"Early events in Japanese encephalitis virus infection: Viral entry","volume":"7","author":"Yun","year":"2018","journal-title":"Pathogens"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abn2018","article-title":"FCHO controls AP2\u2019s initiating role in endocytosis through a PtdIns(4,5)P2-dependent switch","volume":"8","author":"Zaccai","year":"2022","journal-title":"Sci. Adv."},{"key":"B201","doi-asserted-by":"publisher","first-page":"5843","DOI":"10.1039\/d5md00650c","article-title":"Targeting clathrin-mediated endocytosis: recent advances in inhibitor development, mechanistic insights, and therapeutic prospects","volume":"16","author":"Zhang","year":"2025","journal-title":"RSC Med. Chem."},{"key":"B202","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1038\/s41586-018-0121-3","article-title":"Mxra8 is a receptor for multiple arthritogenic alphaviruses","volume":"557","author":"Zhang","year":"2018","journal-title":"Nature"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28915","article-title":"Enterovirus 71 enters human brain microvascular endothelial cells through an ARF6-mediated endocytic pathway","volume":"95","author":"Zhu","year":"2023","journal-title":"J. Med. Virol."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2026.1929024\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:49:29Z","timestamp":1791193769000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2026.1929024\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,5]]},"references-count":203,"alternative-id":["10.3389\/fcimb.2026.1929024"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2026.1929024","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,5]]},"article-number":"1929024"}}