{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:40:58Z","timestamp":1793947258696,"version":"4.8.0"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Candida auris<\/jats:italic>\n                      has emerged as a globally significant healthcare-associated fungal pathogen. Although descriptive studies have reported high mortality for candidemia caused by\n                      <jats:italic>C. auris<\/jats:italic>\n                      , whether the mortality differs from non-\n                      <jats:italic>auris<\/jats:italic>\n                      candidemia remains unclear. We conducted this meta-analysis to compare the mortality between patients with\n                      <jats:italic>C. auris<\/jats:italic>\n                      and non-\n                      <jats:italic>auris<\/jats:italic>\n                      candidemia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed (including MEDLINE), Embase, and Web of Science databases for relevant studies published before June 2026.\u00a0A random-effects model was used for meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 16 articles were included in this meta-analysis. In the pooled crude analysis, mortality was significantly lower in patients with\n                      <jats:italic>C. auris<\/jats:italic>\n                      candidemia than in those with non-\n                      <jats:italic>auris<\/jats:italic>\n                      candidemia (OR\u00a0=\u00a00.77, 95% CI 0.67-0.90). Subgroup analyses showed significant geographic variation (P for interaction = 0.019), with lower mortality observed in studies from Turkey, the Middle East and the Americas, but not in South Asia and Africa. Despite lower mortality,\n                      <jats:italic>C. auris<\/jats:italic>\n                      candidemia was associated with prolonged hospitalization in descriptive analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In this meta-analysis of crude estimates, mortality was significantly lower in patients with\n                      <jats:italic>C. auris<\/jats:italic>\n                      candidemia than in those with non-\n                      <jats:italic>auris<\/jats:italic>\n                      candidemia. However, prolonged hospitalization in\n                      <jats:italic>C. auris<\/jats:italic>\n                      infection highlights its medical resource burden. For clinicians, management of\n                      <jats:italic>C. auris<\/jats:italic>\n                      candidemia should focus on timely diagnosis, appropriate antifungal therapy, and strengthened infection prevention, especially in cases of long-term hospitalization.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1952600","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:38:00Z","timestamp":1790915880000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Mortality of Candida auris candidemia compared with non-auris candidemia: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"16","author":[{"given":"Jing","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Healthcare-Associated Infection Control Center, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Healthcare-Associated Infection Control Center, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Healthcare-Associated Infection Control Center, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Healthcare-Associated Infection Control Center, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Healthcare-Associated Infection Control Center, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-fen","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Healthcare-Associated Infection Control Center, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0313589","article-title":"An overview of healthcare-associated Candida auris outbreaks in Ministry of Health hospitals-Saudi Arabia 2020-2022; retrospective multicentric study","volume":"20","author":"Alanazi","year":"2025","journal-title":"PloS One"},{"key":"B28","doi-asserted-by":"publisher","first-page":"430","DOI":"10.3390\/jof9040430","article-title":"The mortality attributable to candidemia in C. auris is higher than that in other Candida species: myth or reality","volume":"9","author":"Alvarez-Moreno","year":"2023","journal-title":"J. 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