{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:11:06Z","timestamp":1789017066207,"version":"build-2803163510"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The NLRP3 inflammasome is a central innate immune sensor in virus-associated inflammation, yet the global research landscape of NLRP3 in viral infections remains unmapped. This study aimed to characterize its structure, evolution, research hotspots, and translational status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a dual-database bibliometric analysis of publications from the Web of Science Core Collection (WoSCC) and Scopus through April 28, 2026, analyzing each database independently with cross-validation. Publication trends, collaboration networks, journal and co-citation patterns, citation bursts, keyword co-occurrence, and trend topics were examined using bibliometrix, VOSviewer, and CiteSpace.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Publications from WoSCC (n = 1,544) and Scopus (n = 1,495) were analyzed independently and cross-validated. Annual output rose steadily from 2009 to a peak in 2025, expanding most steeply during 2019\u20132022. China and the United States dominated publication output, and cumulative all-affiliation output suggests that China overtook the United States around 2021\u20132022 despite its lower international collaboration ratio. The most productive institutions, led by the Chinese Academy of Sciences, shifted toward Chinese affiliations after 2018\u20132020. High-volume journals such as Frontiers in Immunology sustained routine output, whereas a small number of landmark papers in Nature dominated citation influence. Three recurrent hotspots emerged: viral triggers and NLRP3 activation mechanisms, the balance between antiviral defense and hyperinflammation, and NLRP3-associated cell death with therapeutic targeting. After 2022, trend topics shifted toward therapy, NRF2 regulation, diagnosis, and brain pathology, while clinical translation remained largely preclinical.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study delineates the advancements in NLRP3 inflammasome research related to viral infections by systematically mapping its evolutionary trajectory, core research trends, and priority future directions. The analysis outlines the structural and collaborative landscape of the field and may inform future mechanistic investigations, cross-institutional collaborations, and clinical research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1956027","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:33:20Z","timestamp":1789014800000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Advances in NLRP3 inflammasome research in viral infections: evolution, trends, and future directions"],"prefix":"10.3389","volume":"16","author":[{"given":"Fan","family":"Wu","sequence":"first","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, Jianghan University","place":["Wuhan, China"]},{"name":"College of Traditional Chinese Medicine, Department of Medicine, Jianghan University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xiong","sequence":"additional","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, Jianghan University","place":["Wuhan, China"]},{"name":"College of Traditional Chinese Medicine, Department of Medicine, Jianghan University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Yanqing Hospital of Beijing Chinese Medicine Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefei","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, Jianghan University","place":["Wuhan, China"]},{"name":"College of Traditional Chinese Medicine, Department of Medicine, Jianghan University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Emergency, Yanqing Hospital of Beijing Chinese Medicine Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sicheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Hubei Provincial Hospital of Integrated Chinese and Western Medicine","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.immuni.2009.02.005","article-title":"The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA","volume":"30","author":"Allen","year":"2009","journal-title":"Immunity."},{"key":"B2","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.joi.2017.08.007","article-title":"Bibliometrix: an R-tool for comprehensive science mapping analysis","volume":"11","author":"Aria","year":"2017","journal-title":"J. Informetrics."},{"key":"B3","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: mechanism of assembly, regulation and signalling","volume":"16","author":"Broz","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.tips.2025.04.007","article-title":"Targeting the NLRP3 inflammasome for inflammatory disease therapy","volume":"46","author":"Cabral","year":"2025","journal-title":"Trends Pharmacol. Sci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"3683","DOI":"10.1007\/s11192-021-03873-7","article-title":"International collaboration during the COVID-19 crisis: autumn 2020 developments","volume":"126","author":"Cai","year":"2021","journal-title":"Scientometrics."},{"key":"B6","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/asi.20317","article-title":"CiteSpace II: detecting and visualizing emerging trends and transient patterns in scientific literature","volume":"57","author":"Chen","year":"2006","journal-title":"J. Am. Soc. For. Inf. Sci. Technology."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1745589","article-title":"Top 100 most-cited articles on NLRP3 (2000-2024): a retrospective analysis","volume":"17","author":"Chen","year":"2026","journal-title":"Front. Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s11658-023-00462-9","article-title":"The NLRP3 inflammasome: contributions to inflammation-related diseases","volume":"28","author":"Chen","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"key":"B9","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nm.3806","article-title":"A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases","volume":"21","author":"Coll","year":"2015","journal-title":"Nat. Med."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-024-02046-9","article-title":"China-US research collaborations are in decline \u2014 this is bad news for everyone","author":"Conroy","year":"2024","journal-title":"Nature"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1038\/s41591-020-1051-9","article-title":"An inflammatory cytokine signature predicts COVID-19 severity and survival","volume":"26","author":"Del Valle","year":"2020","journal-title":"Nat. Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1056\/NEJMra2026131","article-title":"Cytokine storm","volume":"383","author":"Fajgenbaum","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/s41569-018-0064-2","article-title":"Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty","volume":"15","author":"Ferrucci","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0236307","article-title":"Consolidation in a crisis: patterns of international collaboration in early COVID-19 research","volume":"15","author":"Fry","year":"2020","journal-title":"PloS One"},{"key":"B15","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","article-title":"Structural mechanisms of NLRP3 inflammasome assembly and activation","volume":"41","author":"Fu","year":"2023","journal-title":"Annu. Rev. Immunol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1016\/j.cell.2017.09.039","article-title":"The DNA inflammasome in human myeloid cells is initiated by a STING-cell death program upstream of NLRP3","volume":"171","author":"Gaidt","year":"2017","journal-title":"Cell."},{"key":"B17","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.immuni.2011.02.006","article-title":"Type I interferon inhibits interleukin-1 production and inflammasome activation","volume":"34","author":"Guarda","year":"2011","journal-title":"Immunity."},{"key":"B18","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/520429a","article-title":"Bibliometrics: the Leiden Manifesto for research metrics","volume":"520","author":"Hicks","year":"2015","journal-title":"Nature."},{"key":"B19","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.107843","article-title":"Traditional Chinese Medicine (TCM) in the treatment of COVID-19 and other viral infections: efficacies and mechanisms","volume":"225","author":"Huang","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1038\/s41423-021-00740-6","article-title":"NLRP3 inflammasome activation and cell death","volume":"18","author":"Huang","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/ni.1861","article-title":"Influenza virus activates inflammasomes via its intracellular M2 ion channel","volume":"11","author":"Ichinohe","year":"2010","journal-title":"Nat. Immunol."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.210389","article-title":"The rapid, massive growth of COVID-19 authors in the scientific literature","volume":"8","author":"Ioannidis","year":"2021","journal-title":"R. Soc Open Sci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1126\/science.1233632","article-title":"Role of tissue protection in lethal respiratory viral-bacterial coinfection","volume":"340","author":"Jamieson","year":"2013","journal-title":"Science."},{"key":"B25","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.cell.2020.11.025","article-title":"Synergism of TNF-alpha and IFN-gamma triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes","volume":"184","author":"Karki","year":"2021","journal-title":"Cell."},{"key":"B26","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.immuni.2011.05.006","article-title":"Toll-like receptors and their crosstalk with other innate receptors in infection and immunity","volume":"34","author":"Kawai","year":"2011","journal-title":"Immunity."},{"key":"B27","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3109\/08830185.2010.529976","article-title":"Pathogen recognition by the innate immune system","volume":"30","author":"Kumar","year":"2011","journal-title":"Int. Rev. Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"aag2045","DOI":"10.1126\/sciimmunol.aag2045","article-title":"ZBP1\/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways","volume":"1","author":"Kuriakose","year":"2016","journal-title":"Sci. Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s10734-019-00464-7","article-title":"Winners and losers in US-China scientific research collaborations","volume":"80","author":"Lee","year":"2020","journal-title":"Higher Education."},{"key":"B30","doi-asserted-by":"publisher","first-page":"697","DOI":"10.2147\/JMDH.S505356","article-title":"Global research trends and focus on the link between heart failure and NLRP3 inflammasome: a bibliometric analysis from 2010 to 2024","volume":"18","author":"Lian","year":"2025","journal-title":"J. Multidiscip. Healthc."},{"key":"B31","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/imr.12534","article-title":"Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases","volume":"277","author":"Man","year":"2017","journal-title":"Immunol. Rev."},{"key":"B32","doi-asserted-by":"publisher","first-page":"2523","DOI":"10.1016\/j.immuni.2023.10.004","article-title":"Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis","volume":"56","author":"Miao","year":"2023","journal-title":"Immunity."},{"key":"B33","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/ni.1980","article-title":"Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome","volume":"12","author":"Nakahira","year":"2011","journal-title":"Nat. Immunol."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003330","article-title":"IL-1beta production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease","volume":"9","author":"Negash","year":"2013","journal-title":"PloS Pathog."},{"key":"B35","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s40037-021-00695-4","article-title":"Bibliometrics: methods for studying academic publishing","volume":"11","author":"Ninkov","year":"2022","journal-title":"Perspect. Med. Educ."},{"key":"B36","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1038\/s41467-023-36323-4","article-title":"Microbiota-derived acetate enhances host antiviral response via NLRP3","volume":"14","author":"Niu","year":"2023","journal-title":"Nat. Commun."},{"key":"B37","doi-asserted-by":"publisher","first-page":"4664","DOI":"10.1038\/s41467-021-25015-6","article-title":"SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation","volume":"12","author":"Pan","year":"2021","journal-title":"Nat. Commun."},{"key":"B38","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3390\/v14010088","article-title":"Influenza A virus infection activates NLRP3 inflammasome through trans-Golgi network dispersion","volume":"14","author":"Pandey","year":"2022","journal-title":"Viruses."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.4375","article-title":"The state of OA: a large-scale analysis of the prevalence and impact of Open Access articles","volume":"6","author":"Piwowar","year":"2018","journal-title":"PeerJ"},{"key":"B40","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1002\/glia.23568","article-title":"Human immunodeficiency virus Type-1 single-stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia","volume":"67","author":"Rawat","year":"2019","journal-title":"Glia."},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1111\/imr.70003","article-title":"Inflammasome activation by RNA respiratory viruses: mechanisms, viral manipulation, and therapeutic insights","volume":"330","author":"Rodrigues","year":"2025","journal-title":"Immunol. Rev."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e20201707","DOI":"10.1084\/jem.20201707","article-title":"Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients","volume":"218","author":"Rodrigues","year":"2021","journal-title":"J. Exp. Med."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00238","article-title":"The PANoptosome: a deadly protein complex driving pyroptosis, apoptosis, and necroptosis (PANoptosis)","volume":"10","author":"Samir","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.antiviral.2017.10.020","article-title":"The role of the NLRP3 inflammasome in regulation of antiviral responses to influenza A virus infection","volume":"148","author":"Sarvestani","year":"2017","journal-title":"Antiviral Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029695","article-title":"TLR2\/MyD88\/NF-kappaB pathway, reactive oxygen species, potassium efflux activates NLRP3\/ASC inflammasome during respiratory syncytial virus infection","volume":"7","author":"Segovia","year":"2012","journal-title":"PloS One"},{"key":"B47","doi-asserted-by":"publisher","first-page":"5529","DOI":"10.1021\/acs.jmedchem.4c02759","article-title":"Discovery of DFV890, a potent sulfonimidamide-containing NLRP3 inflammasome inhibitor","volume":"68","author":"Shen","year":"2025","journal-title":"J. Med. Chem."},{"key":"B48","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1038\/s12276-026-01656-9","article-title":"Molecular mechanisms of NLRP3 inflammasome activation","volume":"58","author":"Shin","year":"2026","journal-title":"Exp. Mol. Med."},{"key":"B49","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.cell.2013.02.054","article-title":"The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation","volume":"153","author":"Subramanian","year":"2013","journal-title":"Cell."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1111\/cts.13576","article-title":"First-in-human phase 1 trial evaluating safety, pharmacokinetics, and pharmacodynamics of NLRP3 inflammasome inhibitor, GDC-2394, in healthy volunteers","volume":"16","author":"Tang","year":"2023","journal-title":"Clin. Transl. Sci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.immuni.2009.02.006","article-title":"The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1","volume":"30","author":"Thomas","year":"2009","journal-title":"Immunity."},{"key":"B52","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/d41586-018-00927-4","article-title":"China declared world's largest producer of scientific articles","volume":"553","author":"Tollefson","year":"2018","journal-title":"Nature."},{"key":"B53","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/s41573-023-00822-2","article-title":"Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets","volume":"23","author":"Vande Walle","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"B54","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s11192-009-0146-3","article-title":"Software survey: VOSviewer, a computer program for bibliometric mapping","volume":"84","author":"van Eck","year":"2010","journal-title":"Scientometrics."},{"key":"B55","doi-asserted-by":"publisher","first-page":"3265","DOI":"10.1007\/s10238-023-01116-y","article-title":"A systematic review of the clinical characteristics of influenza-COVID-19 co-infection","volume":"23","author":"Varshney","year":"2023","journal-title":"Clin. Exp. Med."},{"key":"B56","volume-title":"World Health Statistics 2024: Monitoring Health for the Sdgs, Sustainable Development Goals","year":"2024"},{"key":"B57","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1182\/blood-2012-05-430090","article-title":"CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages","volume":"121","author":"Wu","year":"2013","journal-title":"Blood."},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1053658","article-title":"A bibliometric analysis of NLRP3 inflammasome in acute lung injury\/acute respiratory distress syndrome from 2010 to 2021","volume":"13","author":"Xiao","year":"2022","journal-title":"Front. Immunol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"9437","DOI":"10.1073\/pnas.1407709111","article-title":"China's rise as a major contributor to science and technology","volume":"111","author":"Xie","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1309128","article-title":"Regulation and functions of the NLRP3 inflammasome in RNA virus infection","volume":"13","author":"Yue","year":"2024","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2025.1658752","article-title":"The global trends and clinical progress in influenza co-infection: a visualization and bibliometric analysis, (2005-2025)","volume":"16","author":"Zhang","year":"2025","journal-title":"Front. Microbiol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"3","DOI":"10.29024\/sar.15","article-title":"The new research assessment reform in China and its implementation","volume":"2","author":"Zhang","year":"2020","journal-title":"Scholarly Assess. Rep."},{"key":"B63","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/imr.12909","article-title":"The regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)","volume":"297","author":"Zheng","year":"2020","journal-title":"Immunol. Rev."},{"key":"B64","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2026.1956027\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:33:26Z","timestamp":1789014806000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2026.1956027\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":64,"alternative-id":["10.3389\/fcimb.2026.1956027"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2026.1956027","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,10]]},"article-number":"1956027"}}