{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:02:49Z","timestamp":1790226169052,"version":"4.1.0"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014538","name":"Lembaga Pengelola Dana Pendidikan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014538","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tuberculosis (TB) remains the leading infectious-disease cause of death globally, with an estimated 10.7 million incident cases and 1.23 million deaths in 2024. Its persistence is driven not by microbial factors alone, but by a complex interplay of biological, psychological, and social determinants influencing exposure, vulnerability, and access to care. Despite growing recognition of these biopsychosocial dimensions, the available evidence remains fragmented across disciplines, and no previous review has comprehensively mapped their scope while simultaneously characterizing the structure and evolution of this research field.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted an integrated scoping review and bibliometric analysis. Scopus, PubMed, and Web of Science were searched from database inception through 21 January 2026. Empirical studies examining biological, psychological, or social determinants associated with TB care or treatment outcomes were eligible. Data were extracted using a structured charting framework following Joanna Briggs Institute (JBI) methodology and reported according to the PRISMA Extension for Scoping Reviews (PRISMA-ScR). Bibliometric analyses were performed using VOSviewer and the Bibliometrix R package to characterize publication trends, collaboration networks, and thematic evolution. Study-specific effect estimates were summarized descriptively where available; meta-analysis was not undertaken because of substantial clinical and methodological heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 124 studies were included, identifying 78 determinants across biological (n = 25), psychological (n = 25), and social (n = 28) domains. HIV co-infection, diabetes, malnutrition, smoking, alcohol use, stigma, limited TB knowledge, poverty, and barriers to healthcare access were consistently associated with delayed diagnosis, poor treatment adherence, multidrug-resistant TB (MDR-TB), unsuccessful treatment outcomes, and mortality. Bibliometric analysis demonstrated sustained growth in research output and an expansion from predominantly biomedical topics toward mental health, social determinants, digital health, and data-driven approaches. Integration of findings identified evidence gaps, with several determinants strongly associated with adverse outcomes receiving comparatively limited research attention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Integrating a scoping review with bibliometric analysis provides a comprehensive understanding of biopsychosocial determinants associated with TB care and treatment outcomes while identifying evidence gaps and emerging research priorities. These findings support multidisciplinary TB control strategies addressing biological, psychological, and social determinants to strengthen person-centered care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/osf.io\/8fpky\/<\/jats:ext-link>\n                      , identifier 8fpky.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1958725","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:39:13Z","timestamp":1790224753000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Biopsychosocial determinants of tuberculosis care and treatment outcomes: a scoping review and bibliometric analysis"],"prefix":"10.3389","volume":"16","author":[{"given":"Bayu Satria","family":"Wiratama","sequence":"first","affiliation":[{"name":"Department of Biostatistics, Epidemiology, and Population Health, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada","place":["Yogyakarta, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susaldi","family":"Susaldi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada","place":["Yogyakarta, Indonesia"]},{"name":"Faculty of Health Sciences, Universitas Indonesia Maju","place":["Jakarta, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hendra Setia","family":"Lesmana","sequence":"additional","affiliation":[{"name":"Department of Mental and Community Nursing, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada","place":["Yogyakarta, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Rizal Martua","family":"Damanik","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Nutrition, IPB University","place":["Bogor, West Java, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guntari","family":"Prasetya","sequence":"additional","affiliation":[{"name":"Doctoral Study Program in Nutrition Science, Faculty of Medicine and Nutrition, IPB University","place":["Bogor, West Java, Indonesia"]},{"name":"Department of Nutrition, STIKes Mitra Keluarga","place":["Bekasi, West Java, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rathi","family":"Paramastri","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Public Health, Universitas Ahmad Dahlan","place":["Yogyakarta, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woro Rukmi","family":"Pratiwi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapy, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada","place":["Yogyakarta, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Hamim","family":"Sadewa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada","place":["Yogyakarta, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"15961","DOI":"10.1038\/s41598-025-01059-2","article-title":"Social determinants of tuberculosis in Addis Ababa, Ethiopia: A qualitative study","volume":"15","author":"Abaynew","year":"2025","journal-title":"Sci. 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