{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:00:10Z","timestamp":1790312410842,"version":"4.1.0"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"\n Objective<\/jats:title>\n \n To characterize the convergence of resistance determinants, plasmid-mediated dissemination, and host adaptation in the postoperative\n Raoultella ornithinolytica<\/jats:italic>\n isolate RO0725 through integrated genomic analyses and phenotypic validation. We further sought to evaluate its clinical and One Health risks.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Long-read sequencing was used to generate a complete genome. Subsequent analyses assessed phylogeny, average nucleotide identity, resistance genes, and plasmid comparisons. Phenotypic validation included conjugation assays, bile salt tolerance, biofilm formation, and a\n Galleria mellonella<\/jats:italic>\n infection model.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The RO0725 genome comprised one chromosome and five circular plasmids. RO0725 carried 14 antimicrobial-resistance genes distributed across the chromosome and three resistance-associated plasmids. Chromosomal determinants included intrinsic resistance-associated genes such as\n bla<\/jats:italic>\n ORN-1<\/jats:sub>\n ,\n oqxA10<\/jats:italic>\n ,\n oqxB9<\/jats:italic>\n , and\n fosA9<\/jats:italic>\n . The plasmid pRO0725\u20131 carried a truncated\n mcr<\/jats:italic>\n \u00a0-\u00a010-like element, whereas pRO0725\u20132 harbored\n bla<\/jats:italic>\n KPC-2<\/jats:sub>\n ,\n bla<\/jats:italic>\n CTX-M-3<\/jats:sub>\n ,\n bla<\/jats:italic>\n TEM-1<\/jats:sub>\n ,\n qnrS1<\/jats:italic>\n ,\n dfrA14<\/jats:italic>\n ,\n arr-3<\/jats:italic>\n , and\n aac(6\u2032)-Ib-AKT<\/jats:italic>\n . The IncX3-like plasmid pRO0725\u20133 carried\n bla<\/jats:italic>\n NDM-5<\/jats:sub>\n and\n ble<\/jats:italic>\n -MBL. Both pRO0725\u20132 and pRO0725\u20133 exhibited transferable potential in conjugation assays. RO0725 did not form a near-clonal cluster (defined as \u226410 core-genome SNPs) with any public isolates. RO0725 contained host-adaptation-associated determinants involved in adhesion (\n ecp<\/jats:italic>\n ,\n fim<\/jats:italic>\n , and\n mrk<\/jats:italic>\n ), iron acquisition (\n ent<\/jats:italic>\n ,\n fep<\/jats:italic>\n ,\n ybt<\/jats:italic>\n ,\n irp<\/jats:italic>\n ,\n fyuA<\/jats:italic>\n , and\n iutA<\/jats:italic>\n ), stress response (\n phoP<\/jats:italic>\n ,\n rcsB<\/jats:italic>\n ,\n rpoS<\/jats:italic>\n ,\n acrAB<\/jats:italic>\n , and\n ompA<\/jats:italic>\n ), and cellulose biosynthesis (\n bcs<\/jats:italic>\n ). Phenotypically, RO0725 exhibited enhanced bile salt tolerance, weak biofilm formation, and moderate lethality in the\n G. mellonella<\/jats:italic>\n model.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n RO0725 represents a convergence of transferable multidrug-resistance plasmids and host-adaptation determinants. These findings indicate that\n R. ornithinolytica<\/jats:italic>\n may act as both an opportunistic pathogen and a potential reservoir for the interspecies dissemination of resistance genes. They support its inclusion in hospital and One Health antimicrobial-resistance surveillance.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1966531","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:27:44Z","timestamp":1790310464000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Genomic convergence of mobilome-associated multidrug resistance and host-adaptation determinants in a postoperative Raoultella ornithinolytica isolate carrying blaKPC-2, blaNDM-5, and a truncated mcr-10-like element"],"prefix":"10.3389","volume":"16","author":[{"given":"Ziheng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital of Wannan Medical University","place":["Wuhu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangping","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital of Wannan Medical University","place":["Wuhu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruodan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital of Wannan Medical University","place":["Wuhu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxu","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, The First Affiliated Hospital of Wannan Medical University","place":["Wuhu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiming","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital of Wannan Medical University","place":["Wuhu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital of Wannan Medical University","place":["Wuhu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital of Wannan Medical University","place":["Wuhu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital of Wannan Medical University","place":["Wuhu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110726","article-title":"MacSyFinder: a program to mine genomes for molecular systems with an application to CRISPR-Cas systems","volume":"9","author":"Abby","year":"2014","journal-title":"PloS One"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks406","article-title":"PhiSpy: a novel algorithm for finding prophages in bacterial genomes that combines similarity- and composition-based strategies","volume":"40","author":"Akhter","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1128\/mra.00863-22","article-title":"Genome sequence of a Bangladeshi strain of Raoultella ornithinolytica, a pathogen with metal and antimicrobial resistance genes isolated from a pet cat","volume":"12","author":"Alam","year":"2023","journal-title":"Microbiol. 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