{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:53:04Z","timestamp":1787662384967,"version":"build-2736575974"},"reference-count":42,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R56HL123478, 1R01HL123478-01A1, U24DK112340, HL098407"],"award-info":[{"award-number":["R56HL123478, 1R01HL123478-01A1, U24DK112340, HL098407"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["12FTF11260010"],"award-info":[{"award-number":["12FTF11260010"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"DOI":"10.3389\/fcvm.2017.00049","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T04:00:46Z","timestamp":1501732846000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Activation of Inflammatory and Pro-Thrombotic Pathways in Acute Stress Cardiomyopathy"],"prefix":"10.3389","volume":"4","author":[{"given":"Timothy P.","family":"Fitzgibbons","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne J. K.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Iskandar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josiah","family":"Bote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejen","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumita","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Gerszten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Keaney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Zile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard P.","family":"Aurigemma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,8,3]]},"reference":[{"key":"B1","first-page":"56","article-title":"Takotsubo-type cardiomyopathy due to multivessel spasm","volume-title":"Clinical Aspect of Myocardial Injury: From Ischemia to Heart Failure","author":"Sato","year":"1990"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1136\/heartjnl-2013-304691","article-title":"Takotsubo cardiomyopathy: still much more to learn","volume":"100","author":"Ghadri","year":"2014","journal-title":"Heart"},{"key":"B3","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.amjcard.2013.04.010","article-title":"Frequency of takotsubo cardiomyopathy in postmenopausal women presenting with an acute coronary syndrome","volume":"112","author":"Sy","year":"2013","journal-title":"Am J Cardiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s00059-006-2822-x","article-title":"[Tako-tsubo cardiomyopathy. Incidence in patients with acute coronary syndrome]","volume":"31","author":"Wedekind","year":"2006","journal-title":"Herz"},{"key":"B5","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/ejhf.424","article-title":"Current state of knowledge on takotsubo syndrome: a Position Statement from the Taskforce on Takotsubo Syndrome of the Heart Failure Association of the European Society of Cardiology","volume":"18","author":"Lyon","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"B6","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.hfc.2016.06.010","article-title":"The International Takotsubo Registry: rationale, design, objectives, and first results","volume":"12","author":"Ghadri","year":"2016","journal-title":"Heart Fail Clin"},{"key":"B7","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1056\/NEJMoa1406761","article-title":"Clinical features and outcomes of takotsubo (stress) cardiomyopathy","volume":"373","author":"Templin","year":"2015","journal-title":"N Engl J Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1016\/j.jacc.2016.02.029","article-title":"A case-control study of risk markers and mortality in takotsubo stress cardiomyopathy","volume":"67","author":"Tornvall","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1056\/NEJMoa043046","article-title":"Neurohumoral features of myocardial stunning due to sudden emotional stress","volume":"352","author":"Wittstein","year":"2005","journal-title":"N Engl J Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nrcardio.2014.28","article-title":"The inflammatory response in myocardial injury, repair, and remodelling","volume":"11","author":"Frangogiannis","year":"2014","journal-title":"Nat Rev Cardiol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1161\/CIRCULATIONAHA.113.002781","article-title":"Systolic and diastolic mechanics in stress cardiomyopathy","volume":"129","author":"Medeiros","year":"2014","journal-title":"Circulation"},{"key":"B12","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.hrtlng.2015.04.010","article-title":"Soluble ST2 and troponin I combination: useful biomarker for predicting development of stress cardiomyopathy in patients admitted to the medical intensive care unit","volume":"44","author":"Yang","year":"2015","journal-title":"Heart Lung"},{"key":"B13","doi-asserted-by":"publisher","first-page":"377.e25","DOI":"10.1016\/j.cardfail.2014.01.015","article-title":"Diagnostic utility of cardiac biomarkers in discriminating takotsubo cardiomyopathy from acute myocardial infarction","volume":"20","author":"Randhawa","year":"2014","journal-title":"J Card Fail"},{"key":"B14","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1093\/eurheartj\/eht392","article-title":"A signature of circulating microRNAs differentiates takotsubo cardiomyopathy from acute myocardial infarction","volume":"35","author":"Jaguszewski","year":"2014","journal-title":"Eur Heart J"},{"key":"B15","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1093\/cvr\/cvw174","article-title":"Identifying circulating microRNAs as biomarkers of cardiovascular disease: a systematic review","volume":"111","author":"Navickas","year":"2016","journal-title":"Cardiovasc Res"},{"key":"B16","doi-asserted-by":"publisher","first-page":"7153","DOI":"10.1073\/pnas.1507719112","article-title":"Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy","volume":"112","author":"Hathout","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B17","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1161\/CIRCULATIONAHA.116.021803","article-title":"Aptamer-based proteomic profiling reveals novel candidate biomarkers and pathways in cardiovascular disease","volume":"134","author":"Ngo","year":"2016","journal-title":"Circulation"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e15004","DOI":"10.1371\/journal.pone.0015004","article-title":"Aptamer-based multiplexed proteomic technology for biomarker discovery","volume":"5","author":"Gold","year":"2010","journal-title":"PLoS One"},{"key":"B19","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1001\/jamacardio.2016.0225","article-title":"Differences in the clinical profile and outcomes of typical and atypical takotsubo syndrome: data from the International Takotsubo Registry","volume":"1","author":"Ghadri","year":"2016","journal-title":"JAMA Cardiol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.ahj.2007.11.008","article-title":"Apical ballooning syndrome (tako-tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction","volume":"155","author":"Prasad","year":"2008","journal-title":"Am Heart J"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"key":"B22","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1111\/1467-9868.00346","article-title":"A direct approach to false discovery rates","volume":"64","author":"Storey","year":"2002","journal-title":"J R Stat Soc B Stat Methodol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"W77","DOI":"10.1093\/nar\/gkt439","article-title":"WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013","volume":"41","author":"Wang","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"B24","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc B Methodol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"key":"B26","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.cardfail.2012.04.002","article-title":"Changes in plasma profiles of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in stress-induced cardiomyopathy","volume":"18","author":"Essa","year":"2012","journal-title":"J Card Fail"},{"key":"B27","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1146\/annurev.immunol.23.021704.115835","article-title":"Role of C5a in inflammatory responses","volume":"23","author":"Guo","year":"2005","journal-title":"Annu Rev Immunol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.ijcard.2016.09.008","article-title":"Endothelial function and sympathetic nervous system activity in patients with takotsubo syndrome","volume":"224","author":"Naegele","year":"2016","journal-title":"Int J Cardiol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1016\/j.jacc.2010.03.107","article-title":"Endothelial function and vascular response to mental stress are impaired in patients with apical ballooning syndrome","volume":"56","author":"Martin","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1016\/j.amjmed.2011.05.033","article-title":"Brachial artery flow-mediated dilation in patients with tako-tsubo cardiomyopathy","volume":"124","author":"Vasilieva","year":"2011","journal-title":"Am J Med"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e58","DOI":"10.1016\/j.ijcard.2008.12.208","article-title":"Incidence and treatment of left ventricular apical thrombosis in tako-tsubo cardiomyopathy","volume":"146","author":"Kurisu","year":"2011","journal-title":"Int J Cardiol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"117","DOI":"10.4137\/CMC.S38151","article-title":"Prevalence, clinical characteristics, and predictors of patients with thromboembolic events in takotsubo cardiomyopathy","volume":"10","author":"El-Battrawy","year":"2016","journal-title":"Clin Med Insights Cardiol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1016\/j.amjcard.2013.01.304","article-title":"Stress-induced hyperviscosity in the pathophysiology of takotsubo cardiomyopathy","volume":"111","author":"Cecchi","year":"2013","journal-title":"Am J Cardiol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/0092-8674(94)90420-0","article-title":"The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6","volume":"78","author":"Serafini","year":"1994","journal-title":"Cell"},{"key":"B35","doi-asserted-by":"publisher","first-page":"6530","DOI":"10.1073\/pnas.0511011103","article-title":"Netrin-1 induces angiogenesis via a DCC-dependent ERK1\/2-eNOS feed-forward mechanism","volume":"103","author":"Nguyen","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.yjmcc.2009.11.020","article-title":"Netrin-1 prevents ischemia\/reperfusion-induced myocardial infarction via a DCC\/ERK1\/2\/eNOS s1177\/NO\/DCC feed-forward mechanism","volume":"48","author":"Zhang","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"9840","DOI":"10.1074\/jbc.M110.197079","article-title":"Cardiac myocyte-specific ablation of follistatin-like 3 attenuates stress-induced myocardial hypertrophy","volume":"286","author":"Shimano","year":"2011","journal-title":"J Biol Chem"},{"key":"B38","doi-asserted-by":"publisher","first-page":"5822","DOI":"10.1210\/en.2008-0151","article-title":"Expression of follistatin-related genes is altered in heart failure","volume":"149","author":"Lara-Pezzi","year":"2008","journal-title":"Endocrinology"},{"key":"B39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4137\/IJTR.S2097","article-title":"Kynurenine pathway metabolites in humans: disease and healthy states","volume":"2","author":"Chen","year":"2009","journal-title":"Int J Tryptophan Res"},{"key":"B40","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/nm.2092","article-title":"Kynurenine is an endothelium-derived relaxing factor produced during inflammation","volume":"16","author":"Wang","year":"2010","journal-title":"Nat Med"},{"key":"B41","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/S1043-2760(99)00225-8","article-title":"The new human kallikrein gene family: implications in carcinogenesis","volume":"11","author":"Diamandis","year":"2000","journal-title":"Trends Endocrinol Metab"},{"key":"B42","doi-asserted-by":"publisher","first-page":"e40110","DOI":"10.1371\/journal.pone.0040110","article-title":"Cardiac kallikrein-kinin system is upregulated in chronic volume overload and mediates an inflammatory induced collagen loss","volume":"7","author":"Wei","year":"2012","journal-title":"PLoS One"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcvm.2017.00049\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T23:23:29Z","timestamp":1719357809000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcvm.2017.00049\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,3]]},"references-count":42,"alternative-id":["10.3389\/fcvm.2017.00049"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2017.00049","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,3]]},"article-number":"49"}}