{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:57:23Z","timestamp":1789567043621,"version":"build-2803163510"},"reference-count":124,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:00:00Z","timestamp":1567468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00c3\u00a9bec - Sant\u00c3\u00a9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"DOI":"10.3389\/fcvm.2019.00126","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:18:35Z","timestamp":1567469915000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":52,"title":["Regenerative Effect of Platelet Concentrates in Oral and Craniofacial Regeneration"],"prefix":"10.3389","volume":"6","author":[{"given":"Faez Saleh","family":"Al-Hamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Mahri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haider","family":"Al-Waeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahi","family":"Badran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faleh","family":"Tamimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,9,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.tibtech.2008.11.009","article-title":"Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF)","volume":"27","author":"Dohan Ehrenfest","year":"2009","journal-title":"Trends Biotechnol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.2174\/138920112800624328","article-title":"In search of a consensus terminology in the field of platelet concentrates for surgical use: platelet-rich plasma (PRP), platelet-rich fibrin (PRF), fibrin gel polymerization and leukocytes","volume":"13","author":"Dohan Ehrenfest","year":"2012","journal-title":"Curr Pharm Biotechnol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1111\/jth.14223","article-title":"The use of platelets in regenerative medicine and proposal for a new classification system: guidance from the SSC of the ISTH","volume":"16","author":"Harrison","year":"2018","journal-title":"J Thromb Haemost."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1016\/j.joms.2017.01.022","article-title":"Efficacy of platelet-rich fibrin after mandibular third molar extraction: a systematic review and meta-analysis","volume":"75","author":"Al-Hamed","year":"2017","journal-title":"J Oral Maxillofacial Surg."},{"key":"B5","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1159\/000488061","article-title":"The role of autologous platelet concentrates in alveolar socket preservation: a systematic review","volume":"45","author":"Annunziata","year":"2018","journal-title":"Transfusion Med Hemother."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.2174\/138920112800624391","article-title":"Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 1: periodontal and dentoalveolar surgery","volume":"13","author":"Del Corso","year":"2012","journal-title":"Curr Pharmaceut Biotechnol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4614-2059-0_1","article-title":"Healing of Bone Fracture: general concepts, principles of bone regeneration. Principles Bone Regenerat","volume":"2012","author":"Sela","year":"","journal-title":"("},{"key":"B8","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1359\/jbmr.2002.17.3.513","article-title":"Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing","volume":"17","author":"Cho","year":"2002","journal-title":"J Bone Miner Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1002\/jcb.10435","article-title":"Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation","volume":"88","author":"Gerstenfeld","year":"2003","journal-title":"J Cell Biochem."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1359\/jbmr.2001.16.6.1004","article-title":"Expression of osteoprotegerin, receptor activator of NF-kappaB ligand (osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing","volume":"16","author":"Kon","year":"2001","journal-title":"J Bone Miner Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1002\/stem.103","article-title":"Regenerative effects of transplanted mesenchymal stem cells in fracture healing","volume":"27","author":"Granero-Molto","year":"2009","journal-title":"Stem Cells."},{"key":"B12","doi-asserted-by":"publisher","first-page":"8783","DOI":"10.1128\/MCB.20.23.8783-8792.2000","article-title":"Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12","volume":"20","author":"Lee","year":"2000","journal-title":"Mol Cell Biol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"189","DOI":"10.4103\/0974-2077.150734","article-title":"Principles and methods of preparation of platelet-rich plasma: a review and author's perspective","volume":"7","author":"Dhurat","year":"2014","journal-title":"J Cutaneous Aesthetic Surg."},{"key":"B14","doi-asserted-by":"publisher","first-page":"176060","DOI":"10.1155\/2014\/176060","article-title":"Relevant aspects of centrifugation step in the preparation of platelet-rich plasma","volume":"2014","author":"Perez","year":"2014","journal-title":"ISRN Hematol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1111\/j.1365-2141.1976.tb03586.x","article-title":"Preparation and storage of platelet concentrates. I. Factors influencing the harvest of viable platelets from whole blood","volume":"34","author":"Slichter","year":"1976","journal-title":"Br J Haematol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1046\/j.1537-2995.1976.16276155111.x","article-title":"Optimum centrifugation conditions for the preparation of platelet and plasma products","volume":"16","author":"Kahn","year":"1976","journal-title":"Transfusion."},{"key":"B17","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1177\/0363546511401576","article-title":"Platelet activation by collagen provides sustained release of anabolic cytokines","volume":"39","author":"Harrison","year":"2011","journal-title":"Am J Sports Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"6591717","DOI":"10.1155\/2016\/6591717","article-title":"Platelet-rich plasma: the choice of activation method affects the release of bioactive molecules","volume":"2016","author":"Cavallo","year":"2016","journal-title":"Biomed Res Int."},{"key":"B19","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s12891-016-0920-3","article-title":"Intra-articular injection of photo-activated platelet-rich plasma in patients with knee osteoarthritis: a double-blind, randomized controlled pilot study","volume":"17","author":"Paterson","year":"2016","journal-title":"BMC Musculoskelet Disord."},{"key":"B20","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1016\/j.tripleo.2005.07.009","article-title":"Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: Platelet-related biologic features","volume":"101","author":"Dohan","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"e37","DOI":"10.1016\/j.tripleo.2005.07.008","article-title":"Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: Technological concepts and evolution","volume":"101","author":"Dohan","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1111\/j.1600-0501.2009.01900.x","article-title":"Platelet-rich fibrin membranes as scaffolds for periosteal tissue engineering","volume":"21","author":"Gassling","year":"2010","journal-title":"Clin Oral Implants Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1080\/09537104.2017.1327656","article-title":"Platelet concentrates for bone regeneration: current evidence and future challenges","volume":"29","author":"Badran","year":"2018","journal-title":"Platelets."},{"key":"B24","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1053\/j.seminhematol.2010.03.005","article-title":"Platelet formation","volume":"47","author":"Thon","year":"2010","journal-title":"Semin Hematol."},{"key":"B25","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/B978-0-12-387837-3.00007-9","article-title":"Platelet structure","volume-title":"Platelets","author":"White","year":"2013"},{"key":"B26","first-page":"343","article-title":"Platelet secretion","volume-title":"Platelets","author":"White","year":"2013"},{"key":"B27","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1055\/s-0035-1564835","article-title":"Platelet Physiology. Seminars in thrombosis and hemostasis","volume":"42","author":"Gremmel","year":"2016","journal-title":"Semin Thromb Hemost."},{"key":"B28","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1172\/JCI15463","article-title":"Circulating levels of IGF-1 directly regulate bone growth and density","volume":"110","author":"Yakar","year":"2002","journal-title":"J Clin Invest."},{"key":"B29","doi-asserted-by":"publisher","first-page":"16009","DOI":"10.1038\/boneres.2016.9","article-title":"TGF-beta and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease","volume":"4","author":"Wu","year":"2016","journal-title":"Bone Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1089\/ten.tea.2014.0189","article-title":"Transforming growth factor beta 1 augments calvarial defect healing and promotes suture regeneration","volume":"21","author":"Shakir","year":"2015","journal-title":"Tissue Eng Part A."},{"key":"B31","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s40729-016-0052-4","article-title":"Growth factor and pro-inflammatory cytokine contents in platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), advanced platelet-rich fibrin (A-PRF), and concentrated growth factors (CGF)","volume":"2","author":"Masuki","year":"2016","journal-title":"Int J Implant Dentistry."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1101\/gad.266551.115","article-title":"Fibroblast growth factor signaling in skeletal development and disease","volume":"29","author":"Ornitz","year":"2015","journal-title":"Genes Dev."},{"key":"B33","doi-asserted-by":"publisher","first-page":"105","DOI":"10.3290\/j.cjdr.a38275","article-title":"Effects of combining insulin-like growth factor 1 and platelet-derived growth factor on osteogenesis around dental implants","volume":"20","author":"Zhou","year":"2017","journal-title":"Chin J Dent Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1159\/000046610","article-title":"The role of vascular endothelial growth factor in angiogenesis","volume":"106","author":"Ferrara","year":"2001","journal-title":"Acta Haematol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/9467","article-title":"VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation","volume":"5","author":"Gerber","year":"1999","journal-title":"Nat Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.aanat.2014.06.001","article-title":"BDNF and its TrkB receptor in human fracture healing","volume":"196","author":"Kilian","year":"2014","journal-title":"Ann Anatomy."},{"key":"B37","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1093\/intimm\/dxq431","article-title":"IL-1 plays an important role in the bone metabolism under physiological conditions","volume":"22","author":"Lee","year":"2010","journal-title":"Int Immunol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.bone.2005.06.002","article-title":"Interleukin-6: an osteotropic factor influencing bone formation?","volume":"37","author":"Franchimont","year":"2005","journal-title":"Bone."},{"key":"B39","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1159\/000491742","article-title":"IL-8 enhances therapeutic effects of BMSCs on bone regeneration via CXCR2-mediated PI3k\/Akt signaling pathway","volume":"48","author":"Yang","year":"2018","journal-title":"Cell Physiol Biochem."},{"key":"B40","doi-asserted-by":"publisher","first-page":"20316","DOI":"10.1074\/jbc.M006492200","article-title":"Matrix regulation of skeletal cell apoptosis. Role of calcium and phosphate ions","volume":"276","author":"Adams","year":"2001","journal-title":"J Biol Chem."},{"key":"B41","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/dgd.12288","article-title":"Adenosine Triphosphate stimulates differentiation and mineralization in human osteoblast-like Saos-2 cells","volume":"58","author":"Cutarelli","year":"2016","journal-title":"Dev Growth Differ."},{"key":"B42","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1902\/jop.2015.150302","article-title":"Serotonin inhibits osteoblast differentiation and bone regeneration in rats","volume":"87","author":"Nam","year":"2016","journal-title":"J Periodontol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.bone.2014.11.008","article-title":"Serotonin (5-HT) inhibits Factor XIII-A-mediated plasma fibronectin matrix assembly and crosslinking in osteoblast cultures via direct competition with transamidation","volume":"72","author":"Cui","year":"2015","journal-title":"Bone."},{"key":"B44","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.bone.2013.01.020","article-title":"Polyphosphates inhibit extracellular matrix mineralization in MC3T3-E1 osteoblast cultures","volume":"53","author":"Hoac","year":"2013","journal-title":"Bone."},{"key":"B45","doi-asserted-by":"publisher","first-page":"2661","DOI":"10.1016\/j.actbio.2011.03.007","article-title":"Inorganic polymeric phosphate\/polyphosphate as an inducer of alkaline phosphatase and a modulator of intracellular Ca2+ level in osteoblasts (SaOS-2 cells) in vitro","volume":"7","author":"Muller","year":"2011","journal-title":"Acta Biomater."},{"key":"B46","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1007\/s00264-012-1770-8","article-title":"Serum albumin enhances bone healing in a nonunion femoral defect model in rats: a computer tomography micromorphometry study","volume":"37","author":"Skaliczki","year":"2013","journal-title":"Int Orthopaedics."},{"key":"B47","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/iwj.12109","article-title":"Role of fibronectin in normal wound healing","volume":"12","author":"Lenselink","year":"2015","journal-title":"Int Wound J."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1111\/clr.13370","article-title":"Guided bone regeneration using beta-tricalcium phosphate with and without fibronectin\u2014An experimental study in rats","volume":"29","author":"Escoda-Francoli","year":"2018","journal-title":"Clin Oral Implants Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.bone.2015.10.005","article-title":"Thrombin induced by the extrinsic pathway and PAR-1 regulated inflammation at the site of fracture repair","volume":"83","author":"Sato","year":"2016","journal-title":"Bone."},{"key":"B50","doi-asserted-by":"publisher","first-page":"2562","DOI":"10.1182\/blood-2012-08-447458","article-title":"A novel role for factor VIII and thrombin\/PAR1 in regulating hematopoiesis and its interplay with the bone structure","volume":"122","author":"Aronovich","year":"2013","journal-title":"Blood."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1002\/jbmr.1921","article-title":"Plasminogen plays a crucial role in bone repair","volume":"28","author":"Kawao","year":"2013","journal-title":"J Bone Miner Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.biomaterials.2016.10.004","article-title":"Fibrinogen scaffolds with immunomodulatory properties promote in vivo bone regeneration","volume":"111","author":"Vasconcelos","year":"2016","journal-title":"Biomaterials."},{"key":"B53","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1007\/s00011-010-0220-6","article-title":"The complement cascade as a mediator of tissue growth and regeneration","volume":"59","author":"Rutkowski","year":"2010","journal-title":"Inflamm Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1038\/nrendo.2016.153","article-title":"Mechanisms of diabetes mellitus-induced bone fragility","volume":"13","author":"Napoli","year":"2017","journal-title":"Nat Rev Endocrinol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"3420","DOI":"10.2174\/1381612811319190008","article-title":"Osteoinductive small molecules: growth factor alternatives for bone tissue engineering","volume":"19","author":"Aravamudhan","year":"2013","journal-title":"Curr Pharmaceut Des."},{"key":"B56","doi-asserted-by":"publisher","first-page":"5209","DOI":"10.1182\/blood-2012-07-445080","article-title":"Platelet secretion is kinetically heterogeneous in an agonist-responsive manner","volume":"120","author":"Jonnalagadda","year":"2012","journal-title":"Blood."},{"key":"B57","doi-asserted-by":"publisher","first-page":"2325967116675272","DOI":"10.1177\/2325967116675272","article-title":"Analysis of platelet-rich plasma extraction: variations in platelet and blood components between 4 common commercial kits","volume":"5","author":"Fitzpatrick","year":"2017","journal-title":"Orthopaedic J Sports Med."},{"key":"B58","doi-asserted-by":"publisher","first-page":"6510842","DOI":"10.1155\/2018\/6510842","article-title":"Role of white blood cells in blood- and bone marrow-based autologous therapies","volume":"2018","author":"King","year":"2018","journal-title":"Biomed Res Int."},{"key":"B59","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation. Nature reviews","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Immunology."},{"key":"B60","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1189\/jlb.0206087","article-title":"Arteriogenesis depends on circulating monocytes and macrophage accumulation and is severely depressed in op\/op mice","volume":"80","author":"Bergmann","year":"2006","journal-title":"J Leukocyte Biol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1046\/j.1365-2168.1998.00734.x","article-title":"Lymphocyte function in wound healing and following injury","volume":"85","author":"Schaffer","year":"1998","journal-title":"Br J Surg."},{"key":"B62","doi-asserted-by":"publisher","first-page":"300","DOI":"10.4103\/0970-9290.186231","article-title":"Antimicrobial effect of platelet-rich plasma and platelet-rich fibrin","volume":"27","author":"Badade","year":"2016","journal-title":"Indian J Dent Res."},{"key":"B63","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1159\/000095511","article-title":"Influence of platelet-rich plasma on osteogenic differentiation of mesenchymal stem cells and ectopic bone formation in calcium phosphate ceramics","volume":"183","author":"Kasten","year":"2006","journal-title":"Cells Tissues Organs."},{"key":"B64","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1515\/med-2016-0048","article-title":"Platelet rich plasma: a short overview of certain bioactive components","volume":"11","author":"Pavlovic","year":"2016","journal-title":"Open Med."},{"key":"B65","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1046\/j.1524-475X.1999.00410.x","article-title":"Leukocyte proteinases in wound healing: roles in physiologic and pathologic processes","volume":"7","author":"Barrick","year":"1999","journal-title":"Wound Repair Regener."},{"key":"B66","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1080\/09537104.2017.1317731","article-title":"The contribution of leucocytes to the antimicrobial activity of platelet-rich plasma preparations: a systematic review","volume":"29","author":"D'Asta","year":"2018","journal-title":"Platelets."},{"key":"B67","doi-asserted-by":"publisher","first-page":"e0121713","DOI":"10.1371\/journal.pone.0121713","article-title":"Leukocyte inclusion within a platelet rich plasma-derived fibrin scaffold stimulates a more pro-inflammatory environment and alters fibrin properties","volume":"10","author":"Anitua","year":"2015","journal-title":"PLoS ONE."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1177\/0363546514525593","article-title":"The effect of platelet-rich plasma formulations and blood products on human synoviocytes: implications for intra-articular injury and therapy","volume":"42","author":"Braun","year":"2014","journal-title":"Am J Sports Med."},{"key":"B69","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1563\/AAID-JOI-D-14-00167","article-title":"Platelet-rich fibrin in maxillary sinus augmentation: a systematic review","volume":"41","author":"Ali","year":"2015","journal-title":"J Oral Implantol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jcms.2012.10.015","article-title":"Comparison of two different absorbable membranes for the coverage of lateral osteotomy sites in maxillary sinus augmentation: a preliminary study","volume":"41","author":"Gassling","year":"2013","journal-title":"J Cranio-Maxillo-Facial Surg."},{"key":"B71","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1111\/j.1600-051X.2009.01437.x","article-title":"Effect of platelet-rich plasma on sinus lifting: a randomized-controlled clinical trial","volume":"36","author":"Torres","year":"2009","journal-title":"J Clin Periodontol."},{"key":"B72","first-page":"7","article-title":"Effectiveness of sinus lift procedures for dental implant rehabilitation: a Cochrane systematic review","volume":"3","author":"Esposito","year":"2010","journal-title":"Eur J Oral Implantol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/j.ijom.2016.02.012","article-title":"Effectiveness of platelet-rich plasma as an adjunctive material to bone graft: a systematic review and meta-analysis of randomized controlled clinical trials","volume":"45","author":"Pocaterra","year":"2016","journal-title":"Int J Oral Maxillofac Surg."},{"key":"B74","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1111\/j.1600-051X.2010.01615.x","article-title":"Platelet-rich plasma may prevent titanium-mesh exposure in alveolar ridge augmentation with anorganic bovine bone","volume":"37","author":"Torres","year":"2010","journal-title":"J Clin Periodontol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1902\/jop.2013.130260","article-title":"Platelet-rich plasma-assisted guided bone regeneration for ridge augmentation: a randomized, controlled clinical trial","volume":"85","author":"Eskan","year":"2014","journal-title":"J Periodontol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.jcms.2019.01.012","article-title":"Plasma rich in growth factors (PRGF) in intraoral bone grafting procedures: a systematic review","volume":"47","author":"Dragonas","year":"2019","journal-title":"J Cranio-Maxillo-Facial Surg."},{"key":"B77","doi-asserted-by":"publisher","first-page":"8670832","DOI":"10.1155\/2018\/8670832","article-title":"Efficacy of adjunctive bioactive materials in the treatment of periodontal intrabony defects: a systematic review and meta-analysis","volume":"2018","author":"Zhou","year":"2018","journal-title":"Biomed Res Int."},{"key":"B78","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/jicd.12117","article-title":"Additive effect of autologous platelet concentrates in treatment of intrabony defects: a systematic review and meta-analysis","volume":"7","author":"Panda","year":"2016","journal-title":"J Invest Clin Dentistry."},{"key":"B79","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/cid.12114","article-title":"Clinical efficacy of growth factors to enhance tissue repair in oral and maxillofacial reconstruction: a systematic review","volume":"17","author":"Schliephake","year":"2015","journal-title":"Clin Implant Dent Relat Res."},{"key":"B80","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/jcpe.12658","article-title":"Regenerative potential of leucocyte-and platelet-rich fibrin. Part B: sinus floor elevation, alveolar ridge preservation and implant therapy. A systematic review","volume":"44","author":"Castro","year":"2017","journal-title":"J Clin Periodontol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1097\/ID.0000000000000797","article-title":"Effects of platelet concentrates used in alveolar ridge preservation: a systematic review","volume":"27","author":"Niu","year":"2018","journal-title":"Implant Dent."},{"key":"B82","doi-asserted-by":"publisher","first-page":"201","DOI":"10.4103\/njcp.njcp_1_17","article-title":"Evaluation of the effect of platelet-rich fibrin on the alveolar osteitis incidence and periodontal probing depth after extracting partially erupted mandibular third molars extraction","volume":"21","author":"Unsal","year":"2018","journal-title":"Niger J Clin Pract."},{"key":"B83","doi-asserted-by":"publisher","first-page":"S173","DOI":"10.4103\/jpbs.JPBS_151_17","article-title":"Platelet-rich plasma and incidence of alveolar osteitis in high-risk patients undergoing extractions of mandibular molars: a case-control study","volume":"9","author":"Prataap","year":"2017","journal-title":"J Pharm Bioallied Sci."},{"key":"B84","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/clr.13275","article-title":"The use of platelet-rich fibrin to enhance the outcomes of implant therapy: a systematic review","volume":"18","author":"Strauss","year":"2018","journal-title":"Clin Oral Implants Res."},{"key":"B85","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1111\/j.1600-0765.2009.01236.x","article-title":"The adjunctive use of platelet-rich plasma in the therapy of periodontal intraosseous defects: a systematic review","volume":"45","author":"Kotsovilis","year":"2010","journal-title":"J Periodontal Res."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/j.ijom.2018.01.001","article-title":"Does platelet-rich fibrin have a role in osseointegration of immediate implants?","volume":"47","author":"Diana","year":"2018","journal-title":"Int J Oral Maxillofac Surg."},{"key":"B87","doi-asserted-by":"publisher","first-page":"415","DOI":"10.11607\/prd.1861","article-title":"Treatment of peri-implant bone defects with platelet-rich fibrin","volume":"35","author":"Hamzacebi","year":"2015","journal-title":"Int J Periodontics Restorat Dentistry."},{"key":"B88","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1080\/09537104.2016.1226497","article-title":"The impact of autologous platelet concentrates on endodontic healing: a systematic review","volume":"27","author":"Meschi","year":"2016","journal-title":"Platelets."},{"key":"B89","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.joen.2018.09.003","article-title":"Efficacy of autologous platelet concentrates in regenerative endodontic treatment: a systematic review of human studies","volume":"45","author":"Metlerska","year":"2019","journal-title":"J Endodontics."},{"key":"B90","doi-asserted-by":"publisher","first-page":"81","DOI":"10.17796\/jcpd.35.1.q69168v5268234k9","article-title":"Efficacy of platelet-rich-plasma (PRP) in bone regeneration after cyst enucleation in pediatric patients\u2013a clinical study","volume":"35","author":"Nagaveni","year":"2010","journal-title":"J Clin Pediatr Dentistry."},{"key":"B91","doi-asserted-by":"publisher","first-page":"560","DOI":"10.4103\/0970-9290.176915","article-title":"The autologous platelet rich fibrin: a novel approach in osseous regeneration after cystic enucleation: a pilot study","volume":"26","author":"Meshram","year":"2015","journal-title":"Indian J Dent Res."},{"key":"B92","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/s10006-013-0435-0","article-title":"Effect of platelet-rich plasma on bone regeneration after removal of cysts and benign tumours of the jaws","volume":"18","author":"Ramanathan","year":"2014","journal-title":"Oral Maxillofac Surg."},{"key":"B93","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1002\/lary.25868","article-title":"Use of autologous platelet-rich plasma in complete cleft palate repair","volume":"126","author":"El-Anwar","year":"2016","journal-title":"Laryngoscope."},{"key":"B94","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.otoeng.2011.06.001","article-title":"[Closure of recurrent cleft palate fistulas with plasma rich in growth factors]","volume":"62","author":"Gonzalez-Sanchez","year":"2011","journal-title":"Acta Otorrinolaringol Esp."},{"key":"B95","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.jcms.2010.04.017","article-title":"Reduction of bone resorption by the application of platelet-rich plasma (PRP) in bone grafting of the alveolar cleft","volume":"39","author":"Marukawa","year":"2011","journal-title":"J Cranio-Maxillofac Surg."},{"key":"B96","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jobcr.2013.02.002","article-title":"Alveolar bone graft with platelet rich plasma in cleft alveolus","volume":"3","author":"Gupta","year":"2013","journal-title":"J Oral Biol Craniofac Res."},{"key":"B97","doi-asserted-by":"publisher","first-page":"329","DOI":"10.4103\/njcp.njcp_1_17","article-title":"Efficacy of platelet-rich fibrin combined with autogenous bone graft in the quality and quantity of maxillary alveolar cleft reconstruction","volume":"30","author":"Omidkhoda","year":"2018","journal-title":"Iran J Otorhinolaryngol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1097\/SCS.0000000000004125","article-title":"Evaluating of platelet-rich fibrin in the treatment of alveolar cleft with iliac bone graft by means of volumetric analysis","volume":"29","author":"Saruhan","year":"2018","journal-title":"J Craniofac Surg."},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2019.02.011","article-title":"The use of Platelet-rich Fibrin in the management of medication-related osteonecrosis of the jaw: a case series","author":"Fernando de Almeida Barros Mourao","year":"","journal-title":"J Stomatol Oral Maxillofac Surg."},{"key":"B100","doi-asserted-by":"publisher","first-page":"3982540","DOI":"10.1155\/2018\/3982540","article-title":"Conservative surgical treatment of bisphosphonate-related osteonecrosis of the jaw with Er,Cr:YSGG laser and platelet-rich plasma: a longitudinal study","volume":"2018","author":"Mauceri","year":"2018","journal-title":"Biomed Res Int."},{"key":"B101","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1016\/j.joms.2016.12.005","article-title":"Does the addition of bone morphogenetic protein 2 to platelet-rich fibrin improve healing after treatment for medication-related osteonecrosis of the jaw?","volume":"75","author":"Park","year":"2017","journal-title":"J Oral Maxillofac Surg."},{"key":"B102","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/ors.12318","article-title":"The role of piezoelectric surgery and platelet-rich fibrin in treatment of ORN and MRONJ: a clinical case series","volume":"11","author":"Bilimoria","year":"2018","journal-title":"Oral Surg."},{"key":"B103","first-page":"889","article-title":"Regeneration of mandibular osteoradionecrosis defect with platelet rich plasma gel","volume":"24","author":"Scala","year":"2010"},{"key":"B104","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1097\/SCS.0000000000004958","article-title":"Comparison of the clinical outcomes of buccal advancement flap versus platelet-rich fibrin application for the immediate closure of acute oroantral communications","volume":"30","author":"Bilginaylar","year":"2019","journal-title":"J Craniofac Surg."},{"key":"B105","doi-asserted-by":"publisher","first-page":"e367","DOI":"10.1097\/SCS.0000000000004360","article-title":"Closure of oroantral communication with plasma-rich fibrin membrane","volume":"29","author":"Demetoglu","year":"2018","journal-title":"J Craniofac Surg."},{"key":"B106","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1111\/wrr.12363","article-title":"Platelet-rich plasma for resistant oral erosions of pemphigus vulgaris: a pilot study","volume":"23","author":"EL-Komy","year":"2015","journal-title":"Wound Repair Regen."},{"key":"B107","doi-asserted-by":"publisher","first-page":"398","DOI":"10.11138\/orl\/2017.10.4.398","article-title":"Therapeutic efficiency of platelet gel for the treatment of oral ulcers related to chronic graft versus host disease after allogeneic haematopoietic stem cell transplantation","volume":"10","author":"Picardi","year":"2017","journal-title":"Oral Implantol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1016\/j.joms.2015.03.041","article-title":"Treatment of oral mucosal lesions by scalpel excision and platelet-rich fibrin membrane grafting: a review of 26 sites","volume":"73","author":"Pathak","year":"2015","journal-title":"J Oral Maxillofac Surg."},{"key":"B109","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.ijom.2017.09.014","article-title":"Platelet-rich plasma for the therapeutic management of temporomandibular joint disorders: a systematic review","volume":"47","author":"Bousnaki","year":"2018","journal-title":"Int J Oral Maxillofac Surg."},{"key":"B110","doi-asserted-by":"publisher","first-page":"708","DOI":"10.11607\/jomi.3926","article-title":"Anterior maxilla augmentation using palatal bone block with platelet-rich fibrin: a controlled trial","volume":"31","author":"Moussa","year":"2016","journal-title":"Int J Oral Maxillofac Implants."},{"key":"B111","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1902\/jop.2015.150420","article-title":"Use of platelet-rich fibrin membrane in the treatment of gingival recession: a systematic review and meta-analysis","volume":"87","author":"Moraschini","year":"2016","journal-title":"J Periodontol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/clr.13296","article-title":"The use of platelet-rich plasma to enhance the outcomes of implant therapy: a systematic review","volume":"18","author":"Stahli","year":"2018","journal-title":"Clin Oral Implants Res."},{"key":"B113","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/sj.bdj.2017.916","article-title":"Oral surgery II: Part 3. Cysts of the mouth and jaws and their management","volume":"223","author":"Hill","year":"2017","journal-title":"Br Dent J."},{"key":"B114","doi-asserted-by":"publisher","first-page":"Cd008050","DOI":"10.1002\/14651858.CD008050.pub2","article-title":"Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate","volume":"2011","author":"Guo","year":"2011","journal-title":"Cochrane Database Syst Rev."},{"key":"B115","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1016\/j.jcms.2016.05.004","article-title":"Medication-related osteonecrosis of the jaw: is autologous platelet concentrate application effective for prevention and treatment?","volume":"44","author":"Lopez-Jornet","year":"2016","journal-title":"J Cranio-Maxillo-Facial Surg."},{"key":"B116","doi-asserted-by":"publisher","first-page":"551","DOI":"10.4103\/jisp.jisp_345_18","article-title":"Oral pemphigus without skin lesions treated with pulse steroid therapy","volume":"22","author":"Kala","year":"2018","journal-title":"J Indian Soc Periodontol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.cden.2015.08.004","article-title":"Temporomandibular joint disorders and orofacial pain","volume":"60","author":"Ahmad","year":"2016","journal-title":"Dent Clin N Am."},{"key":"B118","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.jcms.2017.01.010","article-title":"Comparison of intra-articular injection of plasma rich in growth factors versus hyaluronic acid following arthroscopy in the treatment of temporomandibular dysfunction: a randomised prospective study","volume":"45","author":"Fernandez-Ferro","year":"2017","journal-title":"J Cranio-Maxillo-Facial Surg."},{"key":"B119","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/nrrheum.2013.141","article-title":"Platelet-rich plasma for managing pain and inflammation in osteoarthritis","volume":"9","author":"Andia","year":"2013","journal-title":"Nat Rev Rheumatol."},{"key":"B120","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1902\/jop.2007.060302","article-title":"Platelet-rich plasma: growth factors and pro- and anti-inflammatory properties","volume":"78","author":"El-Sharkawy","year":"2007","journal-title":"J Periodontol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/09537104.2017.1293812","article-title":"The impact of the centrifuge characteristics and centrifugation protocols on the cells, growth factors, fibrin architecture of a leukocyte- and platelet-rich fibrin (L-PRF) clot and membrane","author":"Dohan Ehrenfest","year":"2017","journal-title":"Platelets."},{"key":"B122","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1002\/jbmr.3045","article-title":"The selective serotonin reuptake inhibitor fluoxetine directly inhibits osteoblast differentiation and mineralization during fracture healing in mice","volume":"32","author":"Bradaschia-Correa","year":"2017","journal-title":"J Bone Miner Res."},{"key":"B123","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1177\/0022034514549378","article-title":"Selective serotonin reuptake inhibitors and the risk of osseointegrated implant failure: a cohort study","volume":"93","author":"Wu","year":"2014","journal-title":"J Dent Res."},{"key":"B124","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.asmart.2016.11.003","article-title":"Optimisation of platelet concentrates therapy: composition, localisation, duration of action","volume":"7","author":"Yung","year":"2017","journal-title":"Asia-Pacific J Sports Med Arthroscopy Rehabil Technol."}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcvm.2019.00126\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,22]],"date-time":"2019-09-22T12:42:05Z","timestamp":1569156125000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcvm.2019.00126\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,3]]},"references-count":124,"alternative-id":["10.3389\/fcvm.2019.00126"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2019.00126","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,3]]},"article-number":"126"}}