{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:44:58Z","timestamp":1792093498040,"version":"4.4.0"},"reference-count":131,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"DOI":"10.3389\/fcvm.2020.00091","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T04:26:28Z","timestamp":1590553588000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":46,"title":["Transcription Factor KLF14 and Metabolic Syndrome"],"prefix":"10.3389","volume":"7","author":[{"given":"Qianyi","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mete","family":"Civelek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,5,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1038\/s41588-018-0088-x","article-title":"Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition","volume":"50","author":"Small","year":"2018","journal-title":"Nat Genet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/nature09270","article-title":"Biological, clinical and population relevance of 95 loci for blood lipids","volume":"466","author":"Teslovich","year":"2010","journal-title":"Nature"},{"key":"B3","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/ng.609","article-title":"Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis","volume":"42","author":"Voight","year":"2010","journal-title":"Nat Genet"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1111\/j.1538-7836.2012.04815.x","article-title":"Genome-wide association study validation identifies novel loci for atherosclerotic cardiovascular disease","volume":"10","author":"Chen","year":"2012","journal-title":"J Thromb Haemost"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1038\/s41588-018-0241-6","article-title":"Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps","volume":"50","author":"Mahajan","year":"2018","journal-title":"Nat Genet"},{"key":"B6","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/hmg\/ddy327","article-title":"Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry","volume":"28","author":"Pulit","year":"2019","journal-title":"Hum Mol Genet"},{"key":"B7","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/nature14132","article-title":"New genetic loci link adipose and insulin biology to body fat distribution","volume":"518","author":"Shungin","year":"2015","journal-title":"Nature"},{"key":"B8","doi-asserted-by":"publisher","first-page":"4530","DOI":"10.1093\/hmg\/dds282","article-title":"Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans","volume":"21","author":"Chen","year":"2012","journal-title":"Hum Mol Genet"},{"key":"B9","doi-asserted-by":"publisher","first-page":"231515","DOI":"10.1155\/2013\/231515","article-title":"Association of the KLF14 rs4731702 SNP and serum lipid levels in the Guangxi Mulao and Han populations","volume":"2013","author":"Huang","year":"2013","journal-title":"BioMed Res Int."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e26911","DOI":"10.1371\/journal.pone.0026911","article-title":"Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese","volume":"6","author":"Ohshige","year":"2011","journal-title":"PLoS ONE"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1007\/s00125-011-2063-2","article-title":"Replication of 13 genome-wide association (GWA)-validated risk variants for type 2 diabetes in Pakistani populations","volume":"54","author":"Rees","year":"2011","journal-title":"Diabetologia"},{"key":"B12","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.ajhg.2017.01.027","article-title":"Genetic regulation of adipose gene expression and cardio-metabolic traits","volume":"100","author":"Civelek","year":"2017","journal-title":"Am J Hum Genet"},{"key":"B13","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/ng.833","article-title":"Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes","volume":"43","author":"Small","year":"2011","journal-title":"Nat Genet"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1152\/physrev.00058.2009","article-title":"Mammalian kr\u00fcppel-like factors in health and diseases","volume":"90","author":"McConnell","year":"2010","journal-title":"Physiol Rev"},{"key":"B15","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/nrc3582","article-title":"Kr\u00fcppel-like factors in cancer","volume":"13","author":"Tetreault","year":"2013","journal-title":"Nat Rev Cancer"},{"key":"B16","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/ncb1698","article-title":"A core Klf circuitry regulates self-renewal of embryonic stem cells","volume":"10","author":"Jiang","year":"2008","journal-title":"Nat Cell Biol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"W465","DOI":"10.1093\/nar\/gkn180","article-title":"Phylogeny.fr: robust phylogenetic analysis for the non-specialist","volume":"36","author":"Dereeper","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"B18","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1093\/nar\/gkg161","article-title":"Structural classification of zinc fingers survey and summary","volume":"31","author":"Krishna","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"B19","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1006\/geno.2000.6362","article-title":"Identification of KLF13 and KLF14 (SP6), novel members of the SP\/XKLF transcription factor family","volume":"70","author":"Scohy","year":"2000","journal-title":"Genomics"},{"key":"B20","doi-asserted-by":"crossref","DOI":"10.1007\/978-4-431-87775-2","volume-title":"The Biology of Kr\u00fcppel-Like Factors","author":"Nagai","year":"2009"},{"key":"B21","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1158\/1078-0432.CCR-03-0484","article-title":"Nuclear localization of KLF4 is associated with an aggressive phenotype in early-stage breast cancer","volume":"10","author":"Pandya","year":"2004","journal-title":"Clin Cancer Res"},{"key":"B22","doi-asserted-by":"publisher","first-page":"32243","DOI":"10.1074\/jbc.M205677200","article-title":"Kr\u00fcppel-like zinc fingers bind to nuclear import proteins and are required for efficient nuclear localization of erythroid kr\u00fcppel-like factor","volume":"277","author":"Quadrini","year":"2002","journal-title":"J Biol Chem"},{"key":"B23","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/S0092-8674(00)81531-7","article-title":"Sin meets NuRD and other tails of repression","volume":"99","author":"Knoepfler","year":"1999","journal-title":"Cell"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.1016\/j.biocel.2007.07.018","article-title":"Kr\u00fcppel-like transcription factors: a functional family","volume":"40","author":"Pearson","year":"2008","journal-title":"Int J Biochem Cell Biol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1182\/blood-2005-05-1916","article-title":"Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6","volume":"107","author":"Matsumoto","year":"2006","journal-title":"Blood"},{"key":"B26","doi-asserted-by":"publisher","first-page":"5699","DOI":"10.1128\/MCB.25.13.5699-5711.2005","article-title":"Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nervous system","volume":"25","author":"Laub","year":"2005","journal-title":"Mol Cell Biol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1128\/MCB.23.7.2489-2500.2003","article-title":"Functional analysis of basic transcription element binding protein by gene targeting technology","volume":"23","author":"Morita","year":"2003","journal-title":"Mol Cell Biol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1128\/MCB.25.3.1191-1199.2005","article-title":"TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro","volume":"25","author":"Subramaniam","year":"2005","journal-title":"Mol Cell Biol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.bcmd.2004.08.027","article-title":"Functional study of transcription factor KLF11 by targeted gene inactivation","volume":"34","author":"Song","year":"2005","journal-title":"Blood Cells Mol Dis"},{"key":"B30","doi-asserted-by":"publisher","first-page":"5496","DOI":"10.4049\/jimmunol.178.9.5496","article-title":"Kr\u00fcppel-like transcription factor 13 regulates T lymphocyte survival in vivo","volume":"178","author":"Zhou","year":"2007","journal-title":"J Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"7074","DOI":"10.1073\/pnas.0701981104","article-title":"Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy","volume":"104","author":"Fisch","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"B32","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/375318a0","article-title":"Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF","volume":"375","author":"Perkins","year":"1995","journal-title":"Nature"},{"key":"B33","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.1101\/gr.135707.111","article-title":"Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq","volume":"22","author":"Tallack","year":"2012","journal-title":"Genome Res"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.1101\/gad.11.22.2996","article-title":"The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis","volume":"11","author":"Kuo","year":"1997","journal-title":"Genes Dev"},{"key":"B35","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1023\/A:1008809809843","article-title":"Loss of LKLF function results in embryonic lethality in mice","volume":"7","author":"Wani","year":"1998","journal-title":"Transgenic Res"},{"key":"B36","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1242\/dev.129.11.2619","article-title":"The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon","volume":"129","author":"Katz","year":"2002","journal-title":"Development"},{"key":"B37","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cmet.2004.11.005","article-title":"Kr\u00fcppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation","volume":"1","author":"Oishi","year":"2005","journal-title":"Cell Metab"},{"key":"B38","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/11926","article-title":"Klf4 is a transcription factor required for establishing the barrier function of the skin","volume":"22","author":"Segre","year":"1999","journal-title":"Nat Genet"},{"key":"B39","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1038\/nm738","article-title":"Kr\u00fcppel-like zinc-finger transcription factor KLF5\/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling","volume":"8","author":"Shindo","year":"2002","journal-title":"Nat Med"},{"key":"B40","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/nature24277","article-title":"Genetic effects on gene expression across human tissues","volume":"550","year":"2017","journal-title":"Nature"},{"key":"B41","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/nrg3575","article-title":"Systems genetics approaches to understand complex traits","volume":"15","author":"Civelek","year":"2014","journal-title":"Nat Rev Genet"},{"key":"B42","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/ng.842","article-title":"Conducting the metabolic syndrome orchestra","volume":"43","author":"Civelek","year":"2011","journal-title":"Nat Genet"},{"key":"B43","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The genotype-tissue expression (GTEx) project","volume":"45","author":"GTEx","year":"2013","journal-title":"Nat Genet."},{"key":"B44","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1038\/nature08625","article-title":"Parental origin of sequence variants associated with complex diseases","volume":"462","author":"Kong","year":"2009","journal-title":"Nature"},{"key":"B45","doi-asserted-by":"publisher","first-page":"e1001046","DOI":"10.1371\/journal.pbio.1001046","article-title":"A user's guide to the encyclopedia of DNA elements (ENCODE)","volume":"9","author":"Consortium","year":"2011","journal-title":"PLoS Biol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1038\/nbt1010-1045","article-title":"The NIH roadmap epigenomics mapping consortium","volume":"28","author":"Bernstein","year":"2010","journal-title":"Nat Biotechnol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1113\/jphysiol.1941.sp003930","article-title":"The effect of insulin administration on the insulin content of the pancreas1","volume":"100","author":"Best","year":"1941","journal-title":"J Physiol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/S1043-2760(00)00305-2","article-title":"Life and death of the pancreatic \u03b2 cells","volume":"11","author":"Bonner-Weir","year":"2000","journal-title":"Trends Endocrinol Metab"},{"key":"B49","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1146\/annurev.nutr.28.061807.155530","article-title":"Insulin signaling in the pancreatic \u03b2-Cell","volume":"28","author":"Leibiger","year":"2008","journal-title":"Ann Rev Nutr"},{"key":"B50","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.jacbts.2017.09.001","article-title":"Kr\u00fcppel-like factors: crippling and uncrippling metabolic pathways","volume":"3","author":"Pollak","year":"2018","journal-title":"JACC Basic Transl Sci"},{"key":"B51","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.1016\/j.cellsig.2015.07.019","article-title":"Kr\u00fcppel-like factor 14 increases insulin sensitivity through activation of PI3K\/Akt signal pathway","volume":"27","author":"Yang","year":"2015","journal-title":"Cell Signal"},{"key":"B52","doi-asserted-by":"publisher","first-page":"15798","DOI":"10.1074\/jbc.M113.544346","article-title":"New role for kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids","volume":"289","author":"de Assuncao","year":"2014","journal-title":"J Biol Chem"},{"key":"B53","doi-asserted-by":"publisher","first-page":"E756","DOI":"10.1152\/ajpendo.00549.2013","article-title":"Sphingosine kinase 1 regulates adipose proinflammatory responses and insulin resistance","volume":"306","author":"Wang","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"B54","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.bcp.2012.06.009","article-title":"Inhibition of sphingosine kinase 1 enhances cytotoxicity, ceramide levels and ROS formation in liver cancer cells treated with selenite","volume":"84","author":"Chatzakos","year":"2012","journal-title":"Biochem Pharmacol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"2588","DOI":"10.2337\/db10-1221","article-title":"Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes?","volume":"60","author":"Amati","year":"2011","journal-title":"Diabetes"},{"key":"B56","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3389\/fendo.2016.00030","article-title":"Adipose tissue remodeling: its role in energy metabolism and metabolic disorders","volume":"7","author":"Choe","year":"2016","journal-title":"Front Endocrinol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.physbeh.2007.10.010","article-title":"The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance","volume":"94","author":"Goossens","year":"2008","journal-title":"Physiol Behav"},{"key":"B58","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1159\/000471488","article-title":"The metabolic phenotype in obesity: fat mass, body fat distribution, and adipose tissue function","volume":"10","author":"Goossens","year":"2017","journal-title":"Obes Facts"},{"key":"B59","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.cell.2013.12.012","article-title":"What we talk about when we talk about fat","volume":"156","author":"Rosen","year":"2014","journal-title":"Cell"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.2337\/diacare.14.12.1132","article-title":"Metabolic implications of body fat distribution","volume":"14","author":"Bj\u00f6rntorp","year":"1991","journal-title":"Diabetes Care"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1161\/CIRCULATIONAHA.111.067264","article-title":"Body fat distribution and risk of cardiovascular disease","volume":"126","author":"Despr\u00e9s","year":"2012","journal-title":"Circulation."},{"key":"B62","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1001\/archinte.165.7.777","article-title":"Obesity, regional body fat distribution, and the metabolic syndrome in older men and women","volume":"165","author":"Goodpaster","year":"2005","journal-title":"Arch Intern Med"},{"key":"B63","doi-asserted-by":"publisher","first-page":"s57","DOI":"10.1210\/jc.2008-1585","article-title":"Role of body fat distribution and the metabolic complications of obesity","volume":"93","author":"Jensen","year":"2008","journal-title":"None"},{"key":"B64","doi-asserted-by":"publisher","first-page":"10955","DOI":"10.1038\/s41598-017-09723-y","article-title":"Body fat distribution and the risk of incident metabolic syndrome: a longitudinal cohort study","volume":"7","author":"Kwon","year":"2017","journal-title":"Sci Rep"},{"key":"B65","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.cmet.2008.02.001","article-title":"Transcriptional regulation of adipogenesis by KLF4","volume":"7","author":"Birsoy","year":"2008","journal-title":"Cell Metabol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.cmet.2004.12.009","article-title":"Krox20 stimulates adipogenesis via C\/EBPbeta-dependent and -independent mechanisms","volume":"1","author":"Chen","year":"2005","journal-title":"Cell Metab"},{"key":"B67","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.bbrc.2015.12.035","article-title":"c-Jun regulates adipocyte differentiation via the KLF15-mediated mode","volume":"469","author":"Lee","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"B68","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/nm1756","article-title":"SUMOylation of Kr\u00fcppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-\u03b4","volume":"14","author":"Oishi","year":"2008","journal-title":"Nat Med"},{"key":"B69","doi-asserted-by":"publisher","first-page":"26941","DOI":"10.1074\/jbc.M500463200","article-title":"Kr\u00fcppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1","volume":"280","author":"Li","year":"2005","journal-title":"J Biol Chem"},{"key":"B70","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/0092-8674(93)90252-L","article-title":"Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation","volume":"73","author":"Smas","year":"1993","journal-title":"Cell"},{"key":"B71","doi-asserted-by":"publisher","first-page":"e52474","DOI":"10.1371\/journal.pone.0052474","article-title":"Kr\u00fcppel-like factor KLF8 plays a critical role in adipocyte differentiation","volume":"7","author":"Lee","year":"2012","journal-title":"PLoS ONE"},{"key":"B72","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/cdd.2010.100","article-title":"Kr\u00fcppel-like factor KLF9 regulates PPAR\u03b3 transactivation at the middle stage of adipogenesis","volume":"18","author":"Pei","year":"2011","journal-title":"Cell Death Differ"},{"key":"B73","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s13578-015-0016-z","article-title":"KLF13 promotes porcine adipocyte differentiation through PPAR\u03b3 activation","volume":"5","author":"Jiang","year":"2015","journal-title":"Cell Biosci"},{"key":"B74","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/labinvest.2010.170","article-title":"DNA binding - dependent glucocorticoid receptor activity promotes adipogenesis via kr\u00fcppel-like factor 15 gene expression","volume":"91","author":"Asada","year":"2011","journal-title":"Lab Invest"},{"key":"B75","doi-asserted-by":"publisher","first-page":"34322","DOI":"10.1074\/jbc.M201304200","article-title":"The Kr\u00fcppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4","volume":"277","author":"Gray","year":"2002","journal-title":"J Biol Chem"},{"key":"B76","doi-asserted-by":"publisher","first-page":"12867","DOI":"10.1074\/jbc.M410515200","article-title":"Role of kr\u00fcppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis","volume":"280","author":"Mori","year":"2005","journal-title":"J Biol Chem"},{"key":"B77","doi-asserted-by":"publisher","first-page":"7319","DOI":"10.1128\/MCB.20.19.7319-7331.2000","article-title":"Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Kr\u00fcppel-like factor, a novel zinc finger repressor","volume":"20","author":"Uchida","year":"2000","journal-title":"Mol Cell Biol"},{"key":"B78","doi-asserted-by":"publisher","first-page":"2581","DOI":"10.1074\/jbc.M210859200","article-title":"The Kr\u00fcppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-\u03b3 expression and adipogenesis","volume":"278","author":"Banerjee","year":"2003","journal-title":"J Biol Chem"},{"key":"B79","doi-asserted-by":"publisher","first-page":"S161","DOI":"10.1002\/ptr.3054","article-title":"Platycodin D inhibits adipogenesis of 3T3-L1 cells by modulating Kruppel-like factor 2 and peroxisome proliferator-activated receptor gamma","volume":"24","author":"Lee","year":"2010","journal-title":"Phytother Res"},{"key":"B80","doi-asserted-by":"publisher","first-page":"3967","DOI":"10.1128\/MCB.01942-07","article-title":"Targeted disruption of the basic kr\u00fcppel-like factor gene (Klf3) reveals a role in adipogenesis","volume":"28","author":"Sue","year":"2008","journal-title":"Mol Cell Biol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1210\/me.2005-0138","article-title":"Overexpression of Kruppel-like factor 7 regulates adipocytokine gene expressions in human adipocytes and inhibits glucose-induced insulin secretion in pancreatic beta-cell line","volume":"20","author":"Kawamura","year":"2006","journal-title":"Mol Endocrinol"},{"key":"B82","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1093\/abbs\/gmt010","article-title":"Klf7 modulates the differentiation and proliferation of chicken preadipocyte","volume":"45","author":"Zhang","year":"2013","journal-title":"Acta Biochim Biophys Sin"},{"key":"B83","doi-asserted-by":"publisher","first-page":"e0162238","DOI":"10.1371\/journal.pone.0162238","article-title":"RNA-seq analysis reveals a negative role of KLF16 in adipogenesis","volume":"11","author":"Jang","year":"2016","journal-title":"PLoS ONE"},{"key":"B84","doi-asserted-by":"publisher","first-page":"4569","DOI":"10.1007\/s00018-013-1395-0","article-title":"Emerging roles of zinc finger proteins in regulating adipogenesis","volume":"70","author":"Wei","year":"2013","journal-title":"Cell Mol Life Sci"},{"key":"B85","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.ydbio.2012.10.031","article-title":"Role of kruppel-like transcription factors in adipogenesis","volume":"373","author":"Wu","year":"2013","journal-title":"Dev Biol"},{"key":"B86","unstructured":"bioRxiv"},{"key":"B87","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1016\/j.bbrc.2017.12.104","article-title":"DNA methylation of the Klf14 gene region in whole blood cells provides prediction for the chronic inflammation in the adipose tissue","volume":"497","author":"Iwaya","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"B88","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1126\/science.aaf5094","article-title":"Exposing the exposures responsible for type 2 diabetes and obesity","volume":"354","author":"Franks","year":"2016","journal-title":"Science"},{"key":"B89","doi-asserted-by":"publisher","first-page":"67","DOI":"10.21767\/2172-0479.100067","article-title":"The Kruppel-like factor 14 (KLF14), master gene of multiple metabolic phenotypes: putative trans-regulator network","volume":"7","author":"Guewo Fokeng","year":"2016","journal-title":"Transl Biomed"},{"key":"B90","doi-asserted-by":"publisher","first-page":"11089","DOI":"10.1038\/ncomms11089","article-title":"Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes","volume":"7","author":"Bacos","year":"2016","journal-title":"Nat Commun"},{"key":"B91","doi-asserted-by":"publisher","first-page":"3277","DOI":"10.1016\/j.bbadis.2017.09.021","article-title":"Germline deletion of Kr\u00fcppel-like factor 14 does not increase risk of diet induced metabolic syndrome in male C57BL\/6 mice","volume":"1863","author":"Argmann","year":"2017","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B92","doi-asserted-by":"publisher","first-page":"3819","DOI":"10.1172\/JCI79048","article-title":"Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production","volume":"125","author":"Guo","year":"2015","journal-title":"J Clin Invest"},{"key":"B93","doi-asserted-by":"publisher","first-page":"21631","DOI":"10.1074\/jbc.RA117.000184","article-title":"The KLF14 transcription factor regulates hepatic gluconeogenesis in mice","volume":"292","author":"Wang","year":"2017","journal-title":"J Biol Chem"},{"key":"B94","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.placenta.2019.09.013","article-title":"Klf14 is an imprinted transcription factor that regulates placental growth","volume":"88","author":"Koppes","year":"2019","journal-title":"Placenta"},{"key":"B95","doi-asserted-by":"publisher","first-page":"8450","DOI":"10.1038\/ncomms9450","article-title":"Loss of KLF14 triggers centrosome amplification and tumorigenesis","volume":"6","author":"Fan","year":"2015","journal-title":"Nat Commun"},{"key":"B96","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1038\/ng.3977","article-title":"Exome-wide association study of plasma lipids in >300,000 individuals","volume":"49","author":"Liu","year":"2017","journal-title":"Nat Genet"},{"key":"B97","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1038\/ng.2797","article-title":"Discovery and refinement of loci associated with lipid levels","volume":"45","author":"Willer","year":"2013","journal-title":"Nat Genet"},{"key":"B98","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/cphy.c130024","article-title":"Energy metabolism in the liver","volume":"4","author":"Rui","year":"2014","journal-title":"Compr Physiol"},{"key":"B99","doi-asserted-by":"publisher","first-page":"12861","DOI":"10.1073\/pnas.0702509104","article-title":"Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1","volume":"104","author":"Rodgers","year":"2007","journal-title":"PNAS"},{"key":"B100","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.jhep.2007.04.002","article-title":"Insulin resistance in hepatocytes and sinusoidal liver cells: mechanisms and consequences","volume":"47","author":"Leclercq","year":"2007","journal-title":"J Hepatol"},{"key":"B101","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.febslet.2007.11.034","article-title":"Metabolic adaptations through the PGC-1\u03b1 and SIRT1 pathways","volume":"582","author":"Rodgers","year":"2008","journal-title":"FEBS Lett"},{"key":"B102","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1093\/jn\/135.11.2499","article-title":"Comparative aspects of lipid metabolism: impact on contemporary research and use of animal models","volume":"135","author":"Bergen","year":"2005","journal-title":"J Nutr"},{"key":"B103","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/0305-0491(93)90030-9","article-title":"Comparative studies of the serum lipoproteins and lipids in some domestic, laboratory and wild animals","volume":"106","author":"Viti\u0107","year":"1993","journal-title":"Comp Biochem Physiol B."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.carpath.2016.11.003","article-title":"A novel role for the Kr\u00fcppel-like factor 14 on macrophage inflammatory response and atherosclerosis development","volume":"27","author":"Wei","year":"2017","journal-title":"Cardiovasc. Pathol"},{"key":"B105","doi-asserted-by":"publisher","first-page":"e65","DOI":"10.1371\/journal.pgen.0030065","article-title":"Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution","volume":"3","author":"Parker-Katiraee","year":"2007","journal-title":"PLoS Genet"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-57613-8","author":"Sattler","year":"2017","journal-title":"The Immunology of Cardiovascular Homeostasis and Pathology"},{"key":"B107","first-page":"403","article-title":"Endothelial cells","volume-title":"Methods in Pulmonary Research","author":"Stevens","year":""},{"key":"B108","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.atherosclerosis.2018.09.018","article-title":"Kr\u00fcppel-like factor 14, a coronary artery disease associated transcription factor, inhibits endothelial inflammation via NF-\u03baB signaling pathway","volume":"278","author":"Hu","year":"2018","journal-title":"Atherosclerosis"},{"key":"B109","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1530\/ERC-18-0383","article-title":"KLF14 potentiates oxidative adaptation via modulating HO-1 signaling in castrate-resistant prostate cancer","volume":"26","author":"Luo","year":"2019","journal-title":"Endocr Relat Cancer"},{"key":"B110","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1038\/ng.412","article-title":"New common variants affecting susceptibility to basal cell carcinoma","volume":"41","author":"Stacey","year":"2009","journal-title":"Nat Genet"},{"key":"B111","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1038\/ncb1320","article-title":"The polo kinase Plk4 functions in centriole duplication","volume":"7","author":"Habedanck","year":"2005","journal-title":"Nat Cell Biol"},{"key":"B112","doi-asserted-by":"publisher","first-page":"6888","DOI":"10.1073\/pnas.0910941107","article-title":"Plk4 is required for cytokinesis and maintenance of chromosomal stability","volume":"107","author":"Rosario","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"B113","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/nrm3115","article-title":"Mitotic catastrophe: a mechanism for avoiding genomic instability","volume":"12","author":"Vitale","year":"2011","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B114","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1002\/bdra.20795","article-title":"The role of imprinted genes in fetal growth abnormalities","volume":"91","author":"Piedrahita","year":"2011","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"B115","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/35047554","article-title":"Genomic imprinting: parental influence on the genome","volume":"2","author":"Reik","year":"2001","journal-title":"Nat Rev Genet"},{"key":"B116","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/0168-9525(91)90040-W","article-title":"Genomic imprinting in mammalian development: a parental tug-of-war","volume":"7","author":"Moore","year":"1991","journal-title":"Trends Genet"},{"key":"B117","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/BJ20051234","article-title":"The family feud: turning off Sp1 by Sp1-like KLF proteins","volume":"392","author":"Lomberk","year":"2005","journal-title":"Biochem J"},{"key":"B118","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.jcmgh.2014.12.007","article-title":"A novel role for Kruppel-like factor 14 (KLF14) in T-regulatory cell differentiation","volume":"1","author":"Sarmento","year":"2014","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"B119","doi-asserted-by":"publisher","first-page":"6291","DOI":"10.1074\/jbc.M807791200","article-title":"Silencing of the transforming growth factor-\u03b2 (TGF\u03b2) receptor II by Kr\u00fcppel-like factor 14 underscores the importance of a negative feedback mechanism in TGF\u03b2 signaling","volume":"284","author":"Truty","year":"2009","journal-title":"J Biol Chem"},{"key":"B120","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.cell.2012.12.009","article-title":"DNA-binding specificities of human transcription factors","volume":"152","author":"Jolma","year":"2013","journal-title":"Cell"},{"key":"B121","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/nbt.3128","article-title":"C2H2 zinc finger proteins greatly expand the human regulatory lexicon","volume":"33","author":"Najafabadi","year":"2015","journal-title":"Nat Biotechnol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1007\/s00125-006-0269-5","article-title":"Effects of statins on the adipocyte maturation and expression of glucose transporter 4 (SLC2A4): implications in glycaemic control","volume":"49","author":"Nakata","year":"2006","journal-title":"Diabetologia"},{"key":"B123","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.ajhg.2017.01.011","article-title":"Decreased STARD10 expression is associated with defective insulin secretion in humans and mice","volume":"100","author":"Carrat","year":"2017","journal-title":"Am J Hum Genet"},{"key":"B124","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.2337\/db18-1708-P","article-title":"Characterization of a type 2 diabetes\u2013associated islet-specific enhancer cluster in STARD10 by genome editing of endoC-\u00dfH1 cells","volume":"67","author":"Hu","year":"2018","journal-title":"Diabetes"},{"key":"B125","doi-asserted-by":"publisher","first-page":"4162","DOI":"10.1073\/pnas.0230450100","article-title":"Insulin-degrading enzyme regulates the levels of insulin, amyloid \u03b2-protein, and the \u03b2-amyloid precursor protein intracellular domain in vivo","volume":"100","author":"Farris","year":"2003","journal-title":"PNAS"},{"key":"B126","doi-asserted-by":"publisher","first-page":"e001946","DOI":"10.1161\/CIRCGEN.117.001946","article-title":"From genotype to phenotype","volume":"11","author":"Jennie","year":"2018","journal-title":"Circulation."},{"key":"B127","doi-asserted-by":"publisher","first-page":"E3350","DOI":"10.1073\/pnas.1216880109","article-title":"Inducible, reversible system for the rapid and complete degradation of proteins in mammalian cells","volume":"109","author":"Holland","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"B128","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/nmeth.1401","article-title":"An auxin-based degron system for the rapid depletion of proteins in nonplant cells","volume":"6","author":"Nishimura","year":"2009","journal-title":"Nat Methods"},{"key":"B129","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1101\/gad.328237.119","article-title":"An improved auxin-inducible degron system preserves native protein levels and enables rapid and specific protein depletion","volume":"33","author":"Sathyan","year":"2019","journal-title":"Genes Dev"},{"key":"B130","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1021\/jm00120a007","article-title":"Synthesis and pharmacological properties of soft drug derivatives related to perhexiline","volume":"31","author":"Marciniak","year":"1988","journal-title":"J Med Chem"},{"key":"B131","doi-asserted-by":"publisher","first-page":"5552","DOI":"10.1073\/pnas.1603840113","article-title":"Preventing diet-induced obesity in mice by adipose tissue transformation and angiogenesis using targeted nanoparticles","volume":"113","author":"Xue","year":"2016","journal-title":"PNAS"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcvm.2020.00091\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T01:53:22Z","timestamp":1666662802000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcvm.2020.00091\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,27]]},"references-count":131,"alternative-id":["10.3389\/fcvm.2020.00091"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2020.00091","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,27]]},"article-number":"91"}}