{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:00:33Z","timestamp":1784869233670,"version":"3.55.0"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T00:00:00Z","timestamp":1606694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Results from studies on the effects of obesity on sudden cardiac death (SCD) or ventricular tachycardia\/ventricular fibrillation (VT\/VF) in patients with an implantable cardioverter-defibrillator\/cardiac resynchronization therapy defibrillator (ICD\/CRT-D) are inconsistent. Our study aimed to explore the impact of BMI on VT\/VF in patients with an ICD\/CRT-D.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We retrospectively analyzed the data from the Study of Home Monitoring System Safety and Efficacy in Cardiac Implantable Electronic Device\u2013implanted Patients in China. Nine hundred and seventy ICD\/CRT-D patients were enrolled. The outcome was the first occurrence of VT\/VF requiring appropriate ICD\/CRT-D therapy. A general linear model and general additive model were used to assess the relationship between BMI and VT\/VF.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> After a median follow-up of 5.17 years, 352 (36.3%) patients experienced VT\/VF requiring appropriate ICD\/CRT-D therapy. BMI, whether as a continuous variable or a categorical variable classified by various BMI classification criteria, had no significant effect on VT\/VF according to a multivariable Cox proportional hazards model with adjustment for potential confounders. However, a non-linear association between BMI and VT\/VF was identified using a cubic spline function model and smooth curve fitting. The inflection point for the curve was found at a BMI level of 23 kg\/m<jats:sup>2<\/jats:sup>. The hazard ratios (95% confidence intervals) for VT\/VF were 1.12 (1.01\u20131.24) and 0.96 (0.90\u20131.02) to the left and right of the inflection point, respectively.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> BMI is related to VT\/VF in a non-linear manner in patients with an ICD\/CRT-D. Our research suggests a complicated role of BMI in VT\/VF with different impacts at different ranges.<\/jats:p>","DOI":"10.3389\/fcvm.2020.610629","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T05:13:33Z","timestamp":1606713213000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Non-linear Association Between Body Mass Index and Ventricular Tachycardia\/Ventricular Fibrillation in Patients With an Implantable Cardioverter-Defibrillator or Cardiac Resynchronization Therapy Defibrillator: A Multicenter Cohort Study"],"prefix":"10.3389","volume":"7","author":[{"given":"Bin","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangang","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiefu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoguang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,11,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1161\/CIRCULATIONAHA.111.023846","article-title":"Sudden 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