{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T21:15:29Z","timestamp":1764364529450,"version":"3.41.2"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:00:00Z","timestamp":1613088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p><jats:bold>Aim:<\/jats:bold> Peak oxygen uptake (peakVO<jats:sub>2<\/jats:sub>) is one of the strongest predictors of survival in patients with valvular heart disease. The purpose of this study was to determine whether endurance training improves peakVO<jats:sub>2<\/jats:sub> and endurance capacity in patients with moderate-severe aortic and mitral valve disease.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> 30 patients with moderate-severe valvular heart disease were randomly assigned to 12 weeks of endurance training (TG) (<jats:italic>n<\/jats:italic> = 16) or standard care (SC) (<jats:italic>n<\/jats:italic> = 14). PeakVO<jats:sub>2<\/jats:sub> and maximum working capacity (Watt<jats:sub>max<\/jats:sub>) were assessed by cardiopulmonary exercise testing, as well as submaximal endurance test at 80% of peakVO<jats:sub>2<\/jats:sub> at baseline and after 12 weeks.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> There was a significant improvement in peakVO<jats:sub>2<\/jats:sub> from 27.2 \u00b1 5.9 ml\/kg to 30.4 \u00b1 6.3 ml\/kg (<jats:italic>P<\/jats:italic> &amp;lt; 0.001) in TG compared to the SC (peakVO<jats:sub>2<\/jats:sub> from 24.6 \u00b1 4.4 to 24.7 \u00b1 3.8) and in the Watt<jats:sub>max<\/jats:sub> from 151.8 \u00b1 41.0 Watt to 171.2 \u00b1 49.7 Watt in the TG compared to the SC (152.9 \u00b1 35.6 Watt to 149.2 \u00b1 28.4 Watt). The endurance capacity increased significantly from 17.0 \u00b1 9.4 min to 32.8 \u00b1 16.8 min (<jats:italic>p<\/jats:italic> = 0.003) in the TG compared to the SC (11.7 \u00b1 6.2 min to 11.2 \u00b1 7.6 min). The heart rate during the endurance test decreased in the TG from 154 \u00b1 14 b\/min to 142 \u00b1 20 b\/min for the same workload. No changes could be seen in the SC.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Endurance training in patients with moderate to severe valvular heart disease increased significantly the peakVO<jats:sub>2<\/jats:sub> as well as the endurance capacity.<\/jats:p>","DOI":"10.3389\/fcvm.2021.627224","type":"journal-article","created":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T18:11:16Z","timestamp":1613239876000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Endurance Training Improves Oxygen Uptake and Endurance Capacity in Patients With Moderate to Severe Valvular Disease"],"prefix":"10.3389","volume":"8","author":[{"given":"Karin","family":"Vonbank","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Haubenberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael","family":"Rosenhek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Aschauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Idzko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Gabriel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,2,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1161\/CIRCULATIONAHA.106.184461","article-title":"Assessment of functional capacity in clinical and research settings: a scientific statement from the American Heart Association committee on exercise, rehabilitation and prevention of the council on clinical cardiology and the council on cardiovascular","volume":"116","author":"Arena","year":"2007","journal-title":"Circulation."},{"key":"B2","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1161\/CIR.0b013e3181e52e69","article-title":"Clinician\u2018s guide to cardiopulmonary exercise testing in adults: a scientific statement from the American heart association","volume":"122","author":"Balady","year":"2010","journal-title":"Circulation."},{"key":"B3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/ejhf.979","article-title":"Role of CPET in clinical stratification in heart failure. 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