{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T15:35:40Z","timestamp":1788622540110,"version":"build-2803163510"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T00:00:00Z","timestamp":1620604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Although brachial-ankle pulse wave velocity (baPWV) is simple and convenient, its usefulness as an initial screening test for hypertensive patients is not well-known. This study aimed to investigate the association of baPWV with left ventricular (LV) geometry and diastolic function in treatment-naive hypertensive patients.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A total of 202 untreated hypertensive patients (mean age, 62 years; males, 51.5%) without documented cardiovascular diseases were prospectively enrolled. Both baPWV and transthoracic echocardiography were performed on the same day before antihypertensive treatment.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> In multiple linear regression analysis after adjustment for potential confounders, baPWV had significant correlations with structural measurements of LV including relative wall thickness (\u03b2 = 0.219, <jats:italic>P<\/jats:italic> = 0.021) and LV mass index (\u03b2 = 0.286, <jats:italic>P<\/jats:italic> = 0.002), and four diastolic parameters including septal e\u2032 velocity (\u03b2 = \u22120.199, <jats:italic>P<\/jats:italic> = 0.018), E\/e\u2032 (\u03b2 = 0.373, <jats:italic>P<\/jats:italic> &amp;lt; 0.001), left atrial volume index (\u03b2 = 0.334, <jats:italic>P<\/jats:italic> &amp;lt; 0.001), and maximal velocity of tricuspid regurgitation (\u03b2 = 0.401, <jats:italic>P<\/jats:italic> &amp;lt; 0.001). The baPWV was significantly increased in patients with LV hypertrophy, abnormal LV remodeling, or diastolic dysfunction, compared to those without (<jats:italic>P<\/jats:italic> = 0.008, <jats:italic>P<\/jats:italic> = 0.035, and <jats:italic>P<\/jats:italic> &amp;lt; 0.001, respectively). In the receiver operating characteristic curve analysis, the discriminant ability of baPWV in predicting LV hypertrophy and diastolic dysfunction had an area under the curve of 0.646 (95% confidence interval 0.544\u20130.703, <jats:italic>P<\/jats:italic> = 0.004) and 0.734 (95% confidence interval 0.648\u20130.800, <jats:italic>P<\/jats:italic> &amp;lt; 0.001), respectively.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> baPWV was associated with parameters of LV remodeling and diastolic function in untreated hypertensive patients. The baPWV could be a useful screening tool for the early detection of adverse cardiac features among untreated hypertensive patients.<\/jats:p>","DOI":"10.3389\/fcvm.2021.647491","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T05:22:11Z","timestamp":1620624131000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Associations of Brachial-Ankle Pulse Wave Velocity With Left Ventricular Geometry and Diastolic Function in Untreated Hypertensive 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