{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:43:28Z","timestamp":1792701808538,"version":"4.5.0"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>A 60-year-old man presented to our emergency room with severe chest pain. Based on the electrocardiogram and elevated serum troponin T levels, acute coronary syndrome was suspected. Coronary angiography revealed total occlusion of the middle of the left anterior descending coronary artery. However, blood cell count abnormalities were not of concern. Twelve days later, the patient developed hemorrhagic infarction in the right parieto-occipital lobe. Acute coronary syndrome and cerebral hemorrhagic infarction were primarily caused by thrombus formation due to polycythemia vera (PV), based on the presence of increased blood consistency on admission. PV was diagnosed after bone marrow biopsy and genetic testing. The patient was treated with descending cell and antiplatelet therapy. Our case highlights the importance of the urgent identification of PV. When acute myocardial infarction occurs in patients with no significant risk factors for cardiovascular disease, blood routine abnormalities should be paid close attention to. If PV was diagnosed as early as possible, thrombotic and hemorrhagic complications could be prevented in the early stages.<\/jats:p>","DOI":"10.3389\/fcvm.2021.660999","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T15:34:37Z","timestamp":1630683277000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Acute Myocardial Infarction Followed by Cerebral Hemorrhagic Infarction in Polycythemia Vera: Case Report and Literature Review"],"prefix":"10.3389","volume":"8","author":[{"given":"XiangSen","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZhuoTing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ChunChang","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e237","DOI":"10.1016\/j.amjmed.2017.02.016","article-title":"Double the trouble: acute coronary syndrome and ischemic stroke in polycythemia vera","volume":"130","author":"Hosoya","year":"2017","journal-title":"Am J Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1055\/s-2003-44552","article-title":"Hyperviscosity in polycythemia vera and other red cell abnormalities","volume":"29","author":"Kwaan","year":"2003","journal-title":"Semin Thrombosis Hemostasis."},{"key":"B3","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1159\/000360388","article-title":"Aspirin-responsive, migraine-like transient cerebral and ocular ischemic attacks and erythromelalgia in JAK2-positive essential thrombocythemia and polycythemia vera","volume":"133","author":"Michiels","year":"2015","journal-title":"Acta Haematol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.jns.2012.09.012","article-title":"Janus kinase (JAK) 2 V617F mutation in Asian Indians with cerebral venous thrombosis and without overt myeloproliferative disorders","volume":"323","author":"De","year":"2012","journal-title":"J Neurol Sci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/j.0954-6820.1985.tb01629.x","article-title":"Platelet counts in myocardial infarction, angina pectoris and peripheral artery disease","volume":"217","author":"Fagher","year":"1985","journal-title":"Acta Medica Scand."},{"key":"B6","doi-asserted-by":"crossref","first-page":"656","DOI":"10.7326\/0003-4819-123-9-199511010-00003","article-title":"Polycythemia vera: the natural history of 1213 patients followed for 20 years","volume":"123","year":"1995","journal-title":"Ann Internal Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1182\/asheducation-2005.1.409","article-title":"Platelets and thrombosis in myeloproliferative diseases","volume":"2005","author":"Harrison","year":"2005","journal-title":"Hematology."},{"key":"B8","unstructured":"Analysis on 71 patients with polycythemia vera66770\n            XinCH\n            XuJQ\n            SuiJR\n            WangXL\n          22739179Zhongguo Shi Yan Xue Ye Xue Za Zhi.202012"},{"key":"B9","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.jccase.2019.06.001","article-title":"Acute myocardial infarction following sequential multi-vessel occlusion in a case of polycythemia vera","volume":"20","author":"Okabe","year":"2019","journal-title":"J Cardiol Cases."},{"key":"B10","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.repc.2018.09.014","article-title":"A rare cause of acute coronary syndromes in young adults - 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