{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T16:54:10Z","timestamp":1763571250337,"version":"3.41.2"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010167","name":"Shanghai Shen Kang Hospital Development Center","doi-asserted-by":"publisher","award":["NCT03398096"],"award-info":[{"award-number":["NCT03398096"]}],"id":[{"id":"10.13039\/501100010167","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Cardiac shock wave therapy (CSWT) is a non-invasive new option for the treatment of chronic refractory angina pectoris (CRAP). This study aimed to evaluate the safety and efficiency of CSWT in the treatment of CRAP.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Eighty-seven patients with CRAP were randomly allocated into CWST group (<jats:italic>n<\/jats:italic> = 46) and Control group (<jats:italic>n<\/jats:italic> = 41). Canadian Cardiovascular Society (CCS) grade of angina pectoris, Seattle Angina Questionnaire (SAQ) score, 6-min walk test (6MWT), weekly dosage of nitroglycerin, and myocardial perfusion on D-SPECT were determined at baseline and during the follow-up period. Adverse events were also evaluated.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> CSWT was well-tolerated in the CSWT patients. CSWT significantly improved the CCS grade, SAQ score, and 6MWT (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). Imaging examinations showed that the ischemic area was reduced after CSWT. However, no significant changes were observed in the Control group.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> CSWT may improve the myocardial perfusion and reduce clinical symptoms without increasing adverse effects in CRAP patients. It provides a non-invasive and safe clinical therapy for CRAP patients.<\/jats:p><jats:p><jats:bold>Clinical Trial registration:<\/jats:bold><jats:ext-link>www.ClinicalTrials.gov<\/jats:ext-link>, identifier: NCT03398096.<\/jats:p>","DOI":"10.3389\/fcvm.2021.664433","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T06:23:42Z","timestamp":1626848622000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Cardiac Shock Wave Therapy Ameliorates Myocardial Ischemia in Patients With Chronic Refractory Angina Pectoris: A Randomized 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