{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T22:55:40Z","timestamp":1754261740796,"version":"3.41.2"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:00:00Z","timestamp":1626220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Malignant cardiac neoplasms are extremely rare in neonates. Prenatal diagnosis is often not available. Initial symptoms can mimic non-cardiac diseases. We present a pre-mature newborn, birth-weight 2,480 g, 34 gestational weeks, which underwent cardiac surgery due to a cardiac tumor.<\/jats:p><jats:p><jats:bold>Case Summary:<\/jats:bold> This was a 3\u2013rd pregnancy after two spontaneous abortions to a mother with thrombophilia, diabetes, hydramnios, and retroplacental hematoma. The baby was admitted to NICU with transitory respiratory failure and inborn infection; hence oxygen-supplementation and antibiotics were initiated. On day 11 a deterioration with tachypnea, high oxygen requirements, significantly increasing C-reactive protein values were noted. Chest radiographs were unremarkable. On day 18 a life-threatening condition with clinical symptoms of shock was identified. Echocardiography showed a large tumor formation in the right atrium, reduced blood flow in the right ventricle and pulmonary artery. On day 19 cardiac surgery was performed: a large tumor with a myxomatous appearance that occupied the cavity of the right atrium and infiltrated the annulus of the tricuspid valve was extirpated. The front wall was restored with a patch. Hemodynamics was temporarily stabilized. On the following day, ventricular fibrillation and asystole occurred. Despite life support efforts, the outcome was lethal. The histological result confirmed leiomyosarcoma of the right atrium and right ventricular hypotrophy.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Inborn cardiac sarcomas are extremely rare. The prognosis is poor. Due to fast progression in the third trimester, they can be missed by fetal echocardiography in earlier pregnancy. The postnatal clinical course is aggressive, not specific until invasive infiltration or obstruction by the tumor mass occurred. In our case, the sarcoma mimicked an inborn infection, followed by nosocomial infection and septic shock. Despite low incidence, cardiac tumors should be kept in mind and echocardiography should be conducted if there are unclear symptoms with progressive deterioration during the neonatal period.<\/jats:p>","DOI":"10.3389\/fcvm.2021.675202","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T04:55:04Z","timestamp":1626238504000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Cardiac Myosarcoma in a Newborn Infant\u2014A Case Report and Literature Review"],"prefix":"10.3389","volume":"8","author":[{"given":"Liliya","family":"Vakrilova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumen","family":"Marinov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislava","family":"Hitrova-Nikolova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dobri","family":"Dobrev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxim","family":"Denev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stoyan","family":"Lazarov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,7,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/0735-1097(95)80031-B","article-title":"Diagnosis and management of fetal cardiac tumors: a multicenter experience and review of published reports","volume":"26","author":"Holley","year":"1995","journal-title":"J Am Coll Cardiol"},{"key":"B2","first-page":"179","article-title":"A newborn infant with intrapericardial rhabdomyosarcoma: a case report","volume":"50","author":"Tutak","year":"2008","journal-title":"Turk J Pediatr"},{"key":"B3","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1002\/1097-0142(19850815)56:<825::AID-CNCR2820560421>3.0.CO;2-7","article-title":"Primary and secondary tumors of childhood involving the heart, pericardium, and great vessels. A report of 75 cases and review of the literature","volume":"56","author":"Chan","year":"1985","journal-title":"Cancer"},{"key":"B4","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1017\/S1047951100008374","article-title":"Primary pediatric cardiac tumors: a 17 year experience","volume":"9","author":"Sallee","year":"1999","journal-title":"Cardiol Young"},{"key":"B5","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.carpath.2009.07.005","article-title":"Pathological study of primary cardiac and pericardial tumours in a specialist UK Centre: surgical and autopsy series","volume":"19","author":"Patel","year":"2010","journal-title":"Cardiovasc Pathol"},{"key":"B6","first-page":"325","article-title":"Primary tumors of the heart and pericardium","volume":"14","author":"McAllister HA","year":"1979","journal-title":"Pathol Annu"},{"key":"B7","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0002-9149(97)89149-7","article-title":"Frequency of primary tumors of the heart","volume":"77","author":"Reynen","year":"1996","journal-title":"Am J Cardiol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1510\/icvts.2007.156554","article-title":"Epidemiological and pathological characteristics of cardiac tumors: a clinical study of 242 cases","volume":"6","author":"Yu","year":"2007","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"B9","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1750-1172-2-11","article-title":"Cardiac tumours in children","volume":"2","author":"Uzun","year":"2007","journal-title":"Orphanet J Rare Dis"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1016\/S0002-8703(97)70032-2","article-title":"Pediatric primary benign cardiac tumors: a 15-year review","volume":"134","author":"Beghetti","year":"1997","journal-title":"Am Heart J"},{"key":"B11","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s00431-016-2833-4","article-title":"Identification and clinical course of 166 pediatric cardiac tumors","volume":"176","author":"Shi","year":"2017","journal-title":"Eur J Pediatr"},{"key":"B12","doi-asserted-by":"publisher","first-page":"544","DOI":"10.5606\/tgkdc.dergisi.2018.16147","article-title":"Rare operations in pediatric heart surgery: cardiac tumors in childhood","volume":"26","author":"Ko\u00e7","year":"2018","journal-title":"Turk Gogus Kalp Damar Cerrahisi Derg"},{"key":"B13","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1177\/2150135114563938","article-title":"Pediatric cardiac tumors: a 45-year, single-institution review","volume":"6","author":"Linnemeier","year":"2015","journal-title":"World J Pediatr Congenit Heart Surg"},{"key":"B14","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s002460010071","article-title":"Primary heart tumors in the pediatric age group: a review of salient pathologic features relevant for clinicians","volume":"21","author":"Becker","year":"2000","journal-title":"Pediatr Cardiol"},{"key":"B15","first-page":"929","article-title":"Cardiac tumors: the 17-year experience of pediatric cardiology department","volume":"28","author":"Param\u00e9s","year":"2009","journal-title":"Rev Port Cardiol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/s00246-003-0590-4","article-title":"Fetal and neonatal cardiac tumors","volume":"25","author":"Isaacs","year":"2004","journal-title":"Pediatr Cardiol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"112","DOI":"10.23907\/2017.013","article-title":"Primary cardiac tumors in infancy: a case report and literature review","volume":"7","author":"Dominguez","year":"2017","journal-title":"Acad Forensic Pathol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s13019-016-0448-5","article-title":"Primary cardiac tumors in children: a center's experience","volume":"11","author":"Ying","year":"2016","journal-title":"J Cardiothorac Surg"},{"key":"B19","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1080\/14767058.2019.1613365","article-title":"Fetal heart rhabdomyomatosis: a single-center experience","volume":"34","author":"Pavlicek","year":"2021","journal-title":"J Matern Fetal Neonatal Med"},{"key":"B20","first-page":"374","article-title":"Perinatal management of cardiac tumors: a case series","volume":"68","author":"Amelia","year":"2013","journal-title":"Med J Malaysia"},{"key":"B21","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/S0002-9149(97)00587-0","article-title":"Primary and secondary neoplasms of the heart","volume":"80","author":"Roberts","year":"1997","journal-title":"Am J Cardiol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1067\/j.cpradiol.2010.07.002","article-title":"Magnetic resonance imaging of cardiac tumors: part 2, malignant tumors and tumor-like conditions","volume":"40","author":"Randhawa","year":"2011","journal-title":"Curr Probl Diagn Radiol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"69","DOI":"10.5152\/akd.2010.016","article-title":"Assessment of cardiac masses: magnetic resonance imaging versus transthoracic echocardiography","volume":"10","author":"Narin","year":"2010","journal-title":"Anadolu Kardiyol Derg"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1016\/S0735-1097(85)80226-6","article-title":"Intracardiac undifferentiated sarcoma in infancy","volume":"6","author":"Ludomirsky","year":"1985","journal-title":"J Am Coll Cardiol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.jpedsurg.2011.11.052","article-title":"Congenital infantile fibrosarcoma in a very low-birth-weight infant","volume":"47","author":"Mukai","year":"2012","journal-title":"J Pediatr Surg"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2021.675202\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T04:55:10Z","timestamp":1626238510000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2021.675202\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,14]]},"references-count":25,"alternative-id":["10.3389\/fcvm.2021.675202"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2021.675202","relation":{},"ISSN":["2297-055X"],"issn-type":[{"type":"electronic","value":"2297-055X"}],"subject":[],"published":{"date-parts":[[2021,7,14]]},"article-number":"675202"}}