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Cardiovasc. Med."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Previous observational studies have reported an association between psychiatric traits and cardiovascular diseases (CVDs). In this two-sample Mendelian randomization (MR) study, we aimed to investigate the causality between psychiatric traits and CVDs.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Single-nucleotide polymorphisms (SNPs) associated with autism spectrum disorder (ASD), neuroticism, and subjective well-being at genome-wide significance (<jats:italic>P<\/jats:italic> &amp;lt; 1 \u00d7 10<jats:sup>\u22128<\/jats:sup>) were identified from genome-wide association studies. Summary-level data of the outcomes, including coronary artery disease (CAD), myocardial infarction (MI), atrial fibrillation (AF), and heart failure (HF), were obtained from several largest datasets. The inverse-variance weighted (IVW) method was used as our main analyses to conduct this MR study. Sensitivity analyses included the weighted median, the MR-robust adjusted profile score (MR-RAPS), and the MR pleiotropy residual sum and outlier (MR-PRESSO) method. Repeated MR analyses using a more relaxed threshold (<jats:italic>P<\/jats:italic> &amp;lt; 1 \u00d7 10<jats:sup>\u22126<\/jats:sup>) for instruments selection and multivariable MR analyses were also applied to evaluate the robustness of results.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The MR analyses showed that genetic predisposition to ASD was associated with a higher risk of AF [odds ratio (OR), 1.109; 95% confidence interval (CI), 1.023\u20131.201; <jats:italic>P<\/jats:italic> = 0.011] and HF (OR, 1.138; 95% CI, 1.036\u20131.251; <jats:italic>P<\/jats:italic> = 0.007). Neuroticism was casually associated with an increased risk of AF (OR, 1.201; 95% CI, 1.037\u20131.392; <jats:italic>P<\/jats:italic> = 0.015), whereas subjective well-being had a protective effect on HF (OR, 0.732; 95% CI, 0.574\u20130.933; <jats:italic>P<\/jats:italic> = 0.012). No other causal association between psychiatric traits and CVDs was observed. Consistent results were obtained in sensitivity analyses.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> This study provided evidence of causal associations of ASD with a higher risk of AF and HF. Besides, neuroticism was casually associated with an increased risk of AF, and subjective well-being was associated with a decreased risk of HF.<\/jats:p>","DOI":"10.3389\/fcvm.2021.676030","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T05:23:49Z","timestamp":1623389029000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Association of Autism Spectrum Disorder, Neuroticism, and Subjective Well-Being With Cardiovascular Diseases: A Two-Sample Mendelian Randomization 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