{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:48:10Z","timestamp":1753890490015,"version":"3.41.2"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V107B-014","V108C-107","V109C-113"],"award-info":[{"award-number":["V107B-014","V108C-107","V109C-113"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The clinical significance and outcomes of ventricular tachyarrhythmias (VTa) in patients undergoing valve replacement have rarely been reported.<\/jats:p><jats:p><jats:bold>Objective:<\/jats:bold> This study aimed to investigate the incidence and outcome of VTa after surgical valve replacement.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We conducted a population-based retrospective cohort study using data obtained from the Taiwan National Health Insurance Research Database. In total, 10,212 patients were selected after 1:1 propensity-score matching based on the type of prosthetic valve used (mechanical vs. bioprosthetic). Various outcomes during long-term follow-up were analyzed.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> After a median follow-up period of 59.6 months, the crude incidence rate of VTa after surgical valve replacement was 4.8\/1,000 person-years, and the cumulative incidence of VTa persistently increased after surgery. Furthermore, the occurrences of VTa after valve replacement significantly increased the risk of cardiovascular (CV) death (<jats:italic>P<\/jats:italic> &amp;lt; 0.001, HR 1.67, 95% CI 1.41\u20131.96), stroke- (<jats:italic>P<\/jats:italic> &amp;lt; 0.001, HR 1.66, 95% CI 1.37\u20132.01), atrial fibrillation- (<jats:italic>P<\/jats:italic> &amp;lt; 0.001, HR 2.80, 95% CI 2.42\u20133.24), and congestive heart failure-related hospitalization (<jats:italic>P<\/jats:italic> &amp;lt; 0.001, HR 2.61, 95% CI 2.30\u20132.95). Among patients with VTa, all-cause mortality (<jats:italic>P<\/jats:italic> = 0.001, HR 0.49, 95% CI 0.32\u20130.75) and CV death (<jats:italic>P<\/jats:italic> = 0.047, HR 0.58, 95% CI 0.34\u20130.99) in those with implantable cardioverter-defibrillator (ICD) implantation were lower than those without.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The crude incidence rate of VTa after surgical valve replacement was 4.8\/1,000 person-years, and the cumulative incidence of VTa persistently increased during follow-up. The presence of VTa after surgical valve replacement increases hospitalization and CV death, while ICD implantation reduced the mortality rate in these patients.<\/jats:p>","DOI":"10.3389\/fcvm.2021.676897","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T07:14:38Z","timestamp":1626333278000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Significance of Ventricular Tachyarrhythmias in Patients Undergoing Valve Replacement: A Nationwide Population-Based Study"],"prefix":"10.3389","volume":"8","author":[{"given":"Guan-Yi","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo-Liong","family":"Chien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yenn-Jiang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu-Ting","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fa-Po","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,7,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e166","DOI":"10.1016\/j.hrthm.2014.07.024","article-title":"EHRA\/HRS\/APHRS expert consensus on ventricular arrhythmias","volume":"11","author":"Pedersen","year":"2014","journal-title":"Heart Rhythm."},{"key":"B2","first-page":"93","article-title":"Possible mechanisms of arrhythmias in valvular heart disease","volume":"47","author":"Janse","year":"1992","journal-title":"Acta Cardiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1056\/NEJM199102283240901","article-title":"Twelve-year comparison of a Bjork-Shiley mechanical heart valve with porcine bioprostheses","volume":"324","author":"Bloomfield","year":"1991","journal-title":"N Engl J Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1161\/01.CIR.72.4.753","article-title":"Death and other time-related events after valve replacement","volume":"72","author":"Blackstone","year":"1985","journal-title":"Circulation."},{"volume-title":"2015 Annual Report of Kidney Disease in Taiwan","year":"2016","author":"Hsu","key":"B5"},{"key":"B6","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1378\/chest.85.2.211","article-title":"Aortic valve replacement in patients with aortic stenosis. Effect on cardiac arrhythmias","volume":"85","author":"Kostis","year":"1984","journal-title":"Chest."},{"key":"B7","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1046\/j.1460-9592.2002.t01-1-00105.x","article-title":"Radiofrequency catheter ablation of an incessant ventricular tachycardia following valve surgery","volume":"25","author":"Lewalter","year":"2002","journal-title":"Pacing Clin Electrophysiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1161\/CIRCULATIONAHA.108.775221","article-title":"Pulmonary valve replacement in tetralogy of Fallot: impact on survival and ventricular tachycardia","volume":"119","author":"Harrild","year":"2009","journal-title":"Circulation."},{"key":"B9","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1253\/jcj.49.576","article-title":"Ventricular arrhythmias late after aortic and\/or mitral valve replacement","volume":"49","author":"Konishi","year":"1985","journal-title":"Jpn Circ J."},{"key":"B10","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1161\/01.CIR.67.3.674","article-title":"Bundle branch reentry: a possible mechanism of ventricular tachycardia","volume":"67","author":"Touboul","year":"1983","journal-title":"Circulation."},{"key":"B11","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.hrcr.2016.12.005","article-title":"Bundle branch reentrant ventricular tachycardia after transcatheter aortic valve replacement","volume":"3","author":"Singh","year":"2017","journal-title":"HeartRhythm Case Rep."},{"key":"B12","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.ipej.2016.02.004","article-title":"Bundle-branch reentry ventricular tachycardia after transcatheter aortic valve replacement","volume":"15","author":"de la Rosa Riestra","year":"2015","journal-title":"Indian Pacing Electrophysiol J."},{"key":"B13","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1007\/s00392-006-0343-5","article-title":"Bundle branch reentrant tachycardia in a patient with a calcified bicuspid aortic valve and normal ventricular function","volume":"95","author":"Fuller","year":"2006","journal-title":"Clin Res Cardiol."},{"key":"B14","first-page":"551","article-title":"Radiofrequency ablation for bundle branch reentrant tachycardia in a patient with aortic valve replacement and left ventricular dysfunction","volume":"50","author":"Singh","year":"1998","journal-title":"Indian Heart J."},{"key":"B15","doi-asserted-by":"publisher","first-page":"4307","DOI":"10.1161\/01.CIR.96.12.4307","article-title":"Ventricular tachycardia in valvular heart disease: facilitation of sustained bundle-branch reentry by valve surgery","volume":"96","author":"Narasimhan","year":"1997","journal-title":"Circulation."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1161\/CIRCULATIONAHA.107.703157","article-title":"Sustained ventricular tachycardia associated with corrective valve surgery","volume":"116","author":"Eckart","year":"2007","journal-title":"Circulation."},{"key":"B17","doi-asserted-by":"publisher","first-page":"320","DOI":"10.5603\/CJ.2012.0057","article-title":"Sustained monomorphic left ventricular outflow tract tachycardia early after aortic valve replacement","volume":"19","author":"Zaker-Shahrak","year":"2012","journal-title":"Cardiol J."},{"key":"B18","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1111\/j.1540-8159.2008.01052.x","article-title":"Successful radiofrequency catheter ablation of ventricular tachycardia originating from underneath the mechanical prosthetic aortic valve","volume":"31","author":"Yamada","year":"2008","journal-title":"Pacing Clin Electrophysiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.joa.2017.08.006","article-title":"Radiofrequency ablation of ventricular premature contraction originating from a native coronary cusp after transcatheter aortic valve replacement","volume":"33","author":"Tohoku","year":"2017","journal-title":"J Arrhythm."},{"key":"B20","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1002\/ccd.23183","article-title":"Left-ventricular outflow tract ventricular-tachycardia event following CoreValve transcatheter aortic-valve implantation","volume":"79","author":"Dvir","year":"2012","journal-title":"Catheter Cardiovasc Interv."},{"key":"B21","first-page":"439","article-title":"[Pre- and postoperative ventricular arrhythmia in mitral valve insufficiency]","volume":"87","author":"Viguier","year":"1994","journal-title":"Arch Mal Coeur Vaiss."},{"key":"B22","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1253\/jcj.55.951","article-title":"Analysis of perioperative ventricular arrhythmias in valvular heart diseases by Holter ECG recording","volume":"55","author":"Shigemitsu","year":"1991","journal-title":"Jpn Circ J."},{"key":"B23","first-page":"421","article-title":"[Relation between hemodynamics and ventricular arrhythmia in patients with heart valve diseases]","volume":"76","author":"Meinertz","year":"1987","journal-title":"Z Kardiol."},{"key":"B24","first-page":"196","article-title":"[Ventricular arrhythmias in mitral valve disease: incidence, severity and relations to hemodynamic parameters]","volume":"75","author":"von Olshausen","year":"1986","journal-title":"Z Kardiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/0167-5273(92)90081-D","article-title":"Ventricular arrhythmias in aortic valve disease: a further marker of impaired left ventricular function","volume":"34","author":"Mart\u00ednez-Useros","year":"1992","journal-title":"Int J Cardiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/S0003-4975(10)61452-X","article-title":"Left ventricular function in patients with ventricular arrhythmias and aortic valve disease","volume":"35","author":"Santinga","year":"1983","journal-title":"Ann Thorac Surg."},{"key":"B27","first-page":"895","article-title":"[Ventricular arrhythmias in patients with aortic valve disease (author's transl)]","volume":"70","author":"von Olshausen","year":"1981","journal-title":"Z Kardiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/0002-9149(84)90319-9","article-title":"Ventricular arrhythmias before and late after aortic valve replacement","volume":"54","author":"von Olshausen","year":"1984","journal-title":"Am J Cardiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1093\/europace\/euu362","article-title":"Ventricular arrhythmias in aortic valve stenosis before and after transcatheter aortic valve implantation","volume":"17","author":"Tempio","year":"2015","journal-title":"Europace."},{"key":"B30","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.jccase.2014.03.005","article-title":"Recurrent ventricular tachycardia from severe aortic stenosis improves after percutaneous aortic balloon valvuloplasty and transcatheter aortic valve replacement","volume":"9","author":"Calle-Muller","year":"2014","journal-title":"J Cardiol Cases."},{"key":"B31","first-page":"145","article-title":"Ventricular arrhythmias in aortic valve disease before and after aortic valve replacement","volume":"47","author":"Michel","year":"1992","journal-title":"Acta Cardiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1159\/000347085","article-title":"Nonischemic mitral regurgitation: prognostic value of non-sustained ventricular tachycardia after mitral valve surgery","volume":"124","author":"Olafiranye","year":"2013","journal-title":"Cardiology."},{"key":"B33","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1159\/000079789","article-title":"Ventricular arrhythmias in mitral regurgitation: frequency, clinical and prognostic importance, management before and after mitral valve surgery","volume":"41","author":"Hochreiter","year":"2004","journal-title":"Adv Cardiol."}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2021.676897\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T07:14:52Z","timestamp":1626333292000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2021.676897\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,15]]},"references-count":33,"alternative-id":["10.3389\/fcvm.2021.676897"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2021.676897","relation":{},"ISSN":["2297-055X"],"issn-type":[{"type":"electronic","value":"2297-055X"}],"subject":[],"published":{"date-parts":[[2021,7,15]]},"article-number":"676897"}}