{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:49:52Z","timestamp":1753890592808,"version":"3.41.2"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T00:00:00Z","timestamp":1625184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> We evaluated the short and long-term effect of peri-interventional dabigatran therapy on vasomotion, endothelialization, and neointimal formation in a porcine coronary artery stenting model.<\/jats:p><jats:p><jats:bold>Background:<\/jats:bold> Stenting of coronary arteries induces local inflammation, impairs vasomotion and delays endothelialization.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty-eight animals underwent percutaneous coronary intervention (PCI) with drug eluting stents. Sixteen pigs started dabigatran therapy 4 days prior to PCI and continued for 4 days post-stenting, while 12 animals served as controls. Post-stenting dual antiplatelet therapy (75 mg clopidogrel and 100 mg aspirin) was continued in both groups until termination. Immediately post-stenting and at day 3 optical coherence tomography (OCT) was performed in all animals, followed by euthanasia of 8 dabigatran and 4 control animals. The remaining pigs (8 of each group) were followed up for 1 month, with control angiography and OCT. Tissue burden (degree of peri-strut structure\u2014thrombus and\/or fibrin) was evaluated. After euthanasia coronary arteries were harvested for <jats:italic>in-vitro<\/jats:italic> myometry and histology.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Thrombin generation was lower (<jats:italic>p<\/jats:italic> &amp;lt; 0.001) and tissue burden (0.83 \u00b1 0.98 vs. 3.0 \u00b1 2.45; <jats:italic>p<\/jats:italic> = 0.031) was significantly decreased in dabigatran treated animals. After 3 days post-PCI endothelium-dependent vasodilation was significantly improved (77 \u00b1 40% vs. 41 \u00b1 31%, <jats:italic>p<\/jats:italic> = 0.02) in dabigatran animals. Neither quantitative angiography nor histomorphometry showed differences between the groups. Endothelialization was faster in the dabigatran group as compared with controls (<jats:italic>p<\/jats:italic> = 0.045).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Short-term peri-interventional triple therapy with dabigatran, aspirin, and clopidogrel led to an enhanced endothelium dependent vasodilation and faster endothelialization. However, neointimal formation 1-month after stent implantation was comparable between groups.<\/jats:p>","DOI":"10.3389\/fcvm.2021.690476","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T06:44:43Z","timestamp":1625208283000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Peri-interventional Triple Therapy With Dabigatran Improves Vasomotion and Promotes Endothelialization in Porcine Coronary Stenting 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