{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T18:26:59Z","timestamp":1767205619199,"version":"build-2238731810"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T00:00:00Z","timestamp":1630886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Takotsubo syndrome (TS) is a recently recognized serious heart condition that mainly affects women. Despite that 80\u201390% of the patients are women, few studies have focused on sex-specific characteristics such as female sex hormones and reproductive history. The aim of the study was to compare reproductive history in patients with TS with controls.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    This register-based cohort study compared reproductive history and off-spring birth characteristics between 158 TS patients without coronary artery stenoses and 236 age- and sex-matched controls (C) with coronary artery stenoses because of acute coronary syndrome (ACS-C), respectively, 285 without coronary artery stenoses with chest pain (CP-C).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    There were no differences in pregnancy complications between TS and CP-C. Gestational length did not differ, but infants born to TS patients had lower birth weight for gestational age than CP-C with an odds ratio of 1.7 (95% confidence interval 1.2\u20132.5) for infants born small.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The results showing an association between birth weight for gestational age and TS later in life are hypothesis-generating. The association is not likely causal and before delivery of small for gestational age infants can be considered as a risk marker for TS later in life the results need to be confirmed in independent studies\n                  <\/jats:p>","DOI":"10.3389\/fcvm.2021.692122","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T00:43:25Z","timestamp":1630889005000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Reproductive History in Takotsubo Syndrome, A Register-Based Cohort Study"],"prefix":"10.3389","volume":"8","author":[{"given":"Per","family":"Tornvall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans J\u00e4rnbert","family":"Pettersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,9,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1016\/j.jacc.2016.02.029","article-title":"A case-control study of risk markers and mortality in takotsubo stress cardiomyopathy","volume":"67","author":"Tornvall","year":"2016","journal-title":"J Am Coll Cardiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.ijcard.2017.11.007","article-title":"Estradiol protection against toxic effects of catecholamine on electrical properties in human-induced pluripotent stem cell derived cardiomyocytes","volume":"254","author":"El-Battrawy","year":"2018","journal-title":"Int J Cardiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.ijcard.2017.10.047","article-title":"Comprehensive assessment of sex hormones 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growth","volume":"124","author":"Bonamy","year":"2011","journal-title":"Circulation."},{"key":"B7","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1161\/HYPERTENSIONAHA.116.08121","article-title":"Association of pregnancy complications and characteristics with future risk of elevated blood pressure: the v\u00e4sterbotten intervention program","volume":"69","author":"Parikh","year":"2017","journal-title":"Hypertension."},{"key":"B8","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s10286-017-0465-z","article-title":"Epidemiology, pathogenesis, and management of takotsubo syndrome","volume":"28","author":"Y-Hassan","year":"2018","journal-title":"Clin Auton Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"12731","DOI":"10.1038\/s41598-018-31034-z","article-title":"Alteration of \u03b2-Adrenoceptor signaling in left ventricle of acute phase takotsubo syndrome: a human study","volume":"8","author":"Nakano","year":"2018","journal-title":"Sci 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