{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T12:38:02Z","timestamp":1774442282456,"version":"3.50.1"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Lacidipine, a third-generation calcium channel blocker, exerts beneficial effects on the endothelium of hypertensive patients in addition to blood pressure lowering. However, the detailed mechanism underlying Lacidipine-related endothelial protection is still elusive.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Sixteen spontaneous hypertensive rats (SHRs) were randomly divided into two groups: Lacidipine-treated SHR group and saline-treated control group. Tail systolic blood pressure was monitored for four consecutive weeks. Endothelial cells (ECs) were pretreated with Lacidipine prior to being stimulated with H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>, bleomycin, or Lipopolysaccharides (LPS) <jats:italic>in vitro<\/jats:italic>. Then, cell activity, migration, and senescence were measured by Cell Counting Kit-8 assay, transwell assay, and \u03b2-galactosidase staining, respectively. The fluorescent probe 2\u2032, 7\u2032-dichlorofluorescein diacetate (DCFH-DA) was used to assess the intracellular reactive oxygen species (ROS). Related protein expression was detected by Western blotting and immunofluorescence.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Our data showed that Lacidipine treatment lowered the blood pressure of SHRs accompanied by the elevation of CXCR7 expression and suppression of P38 and CCAAT\/enhancer-binding protein beta (C\/EBP-\u03b2) compared with the control group. <jats:italic>In vitro<\/jats:italic> experiments further demonstrated that Lacidipine increased the cell viability and function of ECs under oxidative stress, cell senescence, and inflammatory activation <jats:italic>via<\/jats:italic> the CXCR7\/P38\/signaling pathway.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Our results suggested that Lacidipine plays a protective role in EC senescence, oxidative stress, and inflammatory injury through the regulation of CXCR7\/P38\/C\/EBP-\u03b2 signaling 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