{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:47:40Z","timestamp":1753890460353,"version":"3.41.2"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015763","name":"Szegedi Tudom\u00e1nyegyetem","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015763","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> Hypopituitarism is a rare, often underdiagnosed, complex hormonal disease caused by the decreased secretion of one or more hormones in the pituitary gland. The present study was designed to assess left ventricular (LV) rotational mechanics in patients with treated hypopituitarism. It was also aimed to find possible differences in these parameters according to the origin of hypopituitarism (congenital vs. acquired).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The present prospective study involved 35 treated patients with hypopituitarism; however, 4 patients had to be excluded due to inferior image quality. The mean age of the remaining 31 cases was 56.3 \u00b1 13.2 years (18 males). The control group consisted of 29 age- and sex-matched healthy volunteers (mean age: 55.3 \u00b1 4.8 years, 14 males). In all cases a complete two-dimensional echocardiography examination was performed followed by three-dimensional speckle-tracking echocardiography.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> No significant differences could be found in LV volumes between the controls and patients with hypopituitarism and hypopituitary subgroups. LV apical rotation (8.1 \u00b1 5.1\u00b0 vs. 10.6 \u00b1 3.5\u00b0, <jats:italic>p<\/jats:italic> &amp;lt; 0.05) and LV twist (11.9 \u00b1 5.3\u00b0 vs. 15.1 \u00b1 3.8\u00b0, <jats:italic>p<\/jats:italic> &amp;lt; 0.05) were impaired in the hypopituitary group with normally directed LV rotational mechanics as compared to the healthy controls. However, 13% of patients showed a near absence of LV twist called LV \u201crigid body rotation\u201d (LV-RBR). There were no significant differences regarding LV apical and basal rotations and twist between acquired and congenital hypopituitary subgroups.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Impaired LV apical rotation and twist could be demonstrated in hypopituitarism regardless of its origin. In the present study with small number of patients with hypopituitarism, LV-RBR was present in 13% of cases.<\/jats:p>","DOI":"10.3389\/fcvm.2021.703146","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T04:44:13Z","timestamp":1635309853000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Left Ventricular Rotational Abnormalities in Treated Hypopituitarism: Insights From the Three-Dimensional Speckle-Tracking Echocardiographic MAGYAR-Path Study"],"prefix":"10.3389","volume":"8","author":[{"given":"\u00c1rp\u00e1d","family":"Korm\u00e1nyos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00e1ndor","family":"Gyenes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gnes","family":"Horv\u00e1th","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00f3ra","family":"Ambrus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csaba","family":"Lengyel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsuzsanna","family":"Valkusz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Nemes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,27]]},"reference":[{"volume-title":"Hypopituitarism","year":"2021","author":"Gounden","key":"B1"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1046\/j.1365-2265.1999.00682.x","article-title":"Cardiovascular disease and risk factors in adults with hypopituitarism","volume":"50","author":"Beshyah","year":"1999","journal-title":"Clin Endocrinol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000485997","article-title":"Metabolic syndrome in hypopituitarism","volume":"49","author":"Miljic","year":"2018","journal-title":"Front Horm Res"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.3275\/8717","article-title":"The cardiovascular system in growth hormone excess and growth hormone deficiency","volume":"35","author":"Lombardi","year":"2012","journal-title":"J Endocrinol Invest"},{"key":"B5","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1111\/echo.14285","article-title":"Normal values of left ventricular rotational parameters in healthy adults-Insights from the three-dimensional speckle tracking echocardiographic MAGYAR-Healthy Study","volume":"36","author":"Kormanyos","year":"2019","journal-title":"Echocardiography"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1556\/650.2015.30264","article-title":"[Recent echocardiographic examination of the left ventricle - 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